Results 101 to 110 of about 706,514 (296)

Are hepatitis C virus genotypes 1a and 1b so diffrent? [PDF]

Hepatology, 1995
J M Pawlotsky, F Roudot-Thoraval, A Bastie, C Pellet, J Duval, D Dhumeaux   +5 more
openaire   +2 more sources

GBS‐MeDIP: A method for the simultaneous identification of genetic and epigenetic variants in tumors

FEBS Open Bio, EarlyView.
GBS‐MeDIP combines DNA sequencing with enrichment of methylated DNA to profile genetic and epigenetic variation in the same reduced genomic fraction. Applied to gastric cancer and parathyroid tumors, it identifies sequence variants, copy number changes, and differentially methylated regions together, helping distinguish true epigenetic changes from ...
Fábio Pértille, Shiva Rezaei, Julia Uffenorde, Oliver Gimm, Mohammad Ali Hosseinpour Feizi, Luiz Lehmann Coutinho, Carlos Guerrero‐Bosagna   +6 more
wiley   +1 more source

Nucleotide (nt265–285) and Amino Acid (aa89–95) Sequences in the NS5A Region of 647 Genotype 1b HCV Strains in the Database.

, 2014
The figures in the lower panel denote the number of HCV strains showing each nucleotide (nt273, 276, 277, 279) among the 647 genotype 1b HCV strains.
Satoshi Mochida (156566), Jun-ichi Kouyama (661243), Yoshihito Uchida (661242), Kayoko Naiki (661244)   +3 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

A natural inter-genotypic (2b/1b) recombinant of hepatitis C virus in the Philippines

Journal of Medical Virology, 2006
The prevalence study and the characterization of hepatitis C virus (HCV) was carried out in the Philippines and the sequence determination of the 5'-untranslated region (5'-UTR)-Core and the NS5B regions of HCV was carried out in this study. An HCV strain (SE-03-07-1689) collected in Metro Manila, Philippines, belonged to discordant subtypes, 2b and 1b
Seiji, Kageyama, Dorothy M, Agdamag, Evelyn T, Alesna, Prisca S, Leaño, Anna Marie L, Heredia, Ilya P, Abellanosa-Tac-An, Lourdes D, Jereza, Tomoaki, Tanimoto, Jun-ichi, Yamamura, Hiroshi, Ichimura   +9 more
openaire   +3 more sources

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

The demographic and clinical features of 278 patients with genotype 1b hepatitis C virus (HCV) infection receiving daclatasvir (DCV) plus asunaprevir (ASV) therapy.

, 2018
The demographic and clinical features of 278 patients with genotype 1b hepatitis C virus (HCV) infection receiving daclatasvir (DCV) plus asunaprevir (ASV) therapy.
Kayoko Sugawara (5848991), Yukinori Imai (5849006), Nobuaki Nakayama (5849003), Masamitsu Nakao (5848994), Mie Inao (5849000), Satoshi Mochida (156566), Jun-ichi Kouyama (661243), Daisuke Motoya (5848997), Yoshihito Uchida (661242), Kayoko Naiki (661244), Tomoaki Tomiya (479370)   +10 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

A multicenter evaluation of the Abbott RealTime HCV genotype II assay

Microbiologia Medica, 2009
Viral genotype is an important determinant of the therapeutical outcome of the chronic hepatitis C and is useful in clinical practice to determine the duration of treatment1.While the viral type shows a clear association with therapeutic success, there ...
Marco Ciotti, Fulvia Milano, Mosè Favarato, Federico Chiodo, Franceso Renato Pulvirenti, Carlo Federico Perno   +5 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source