Results 81 to 90 of about 263,661 (293)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

CYP3A5*3, CYP3A4*1B and MDR1 C3435T Genotype Distributions in Ecuadorians [PDF]

Disease Markers, 2008
Polymorphisms in CYP3A genes, such as CYP3A5 and CYP3A4, as well as in the MDR1 gene, which encodes for P‐glycoprotein, have been implicated as genetic markers in several disorders. Differences in the frequency distribution of the allelic variants CYP3A5*3, CYP3A4*1B, and MDR1 3435T have been demonstrated between distinct ethnic groups.
Sinués, Blanca, Vicente, Jorge, Fanlo, Ana, Mayayo-Sinués, Esteban, González-Andrade, Fabricio, Sánchez-Q, Dora, Martínez-Jarreta, Begoña   +6 more
openaire   +2 more sources

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

A Hepatitis C Virus-Associated Chronic Hepatitis Patient Developing Various Adverse Events Including Severe Gingivitis, Gingival Bleeding, and Inflammation of Genital Vulva during the Course of Antiviral Therapy with Elbasvir/Grazoprevir

Case Reports in Gastroenterology, 2017
Oral direct-acting antivirals comprise the main therapy for hepatitis C virus (HCV)-associated liver disease in Japan. Daclatasvir/asunaprevir is the primary agent and sofosbuvir/ledipasvir is the secondary agent for HCV genotype 1b.
Kazuo Tarao, Akira Sato
doaj   +1 more source

Hepatitis C virus genotype 1b, cirrhosis, and risk of hepatocellular carcinoma [PDF]

Hepatology, 2008
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Sangiovanni, Angelo, Iavarone, Massimo
openaire   +1 more source

HCV genotype 1 subtypes (1a and 1b): similarities and differences in clinical features and therapeutic outcome.

, 2015
Background and aim: The majority of clinical trials assessed treatment response rate among HCV-1a and 1b patients as a single group. Moreover only few trials were sufficiently powered to detect an eventual difference, whereas the observed data were ...
Ippolito AM, Fasano M, Morisco F, Gaeta G. B., Valvano MR, Santantonio T., Granata R., Felder M., Fasano M., FATTOVICH, Giovanna, Smedile A, Fattovich G., Di Marco V, Felder M, Morisco F., Gatti P., Mazzella G., Andriulli A., Smedile A., Gatti P, Valvano M. R., Ippolito A. M., Milella M., Milella M, Granata R, Andriulli A, Gaeta GB, Di Marco V., Angelico M, Mazzella G, Angelico M.   +30 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Using NS5B Sequencing for Hepatitis C Virus Genotyping Reveals Discordances with Commercial Platforms.

PLoS ONE, 2016
We aimed to evaluate the correct assignment of HCV genotypes by three commercial methods-Trugene HCV genotyping kit (Siemens), VERSANT HCV Genotype 2.0 assay (Siemens), and Real-Time HCV genotype II (Abbott)-compared to NS5B sequencing.
Natalia Chueca, Isidro Rivadulla, Rubén Lovatti, Gabriel Reina, Ana Blanco, Jose Angel Fernandez-Caballero, Laura Cardeñoso, Javier Rodriguez-Granjer, Miriam Fernandez-Alonso, Antonio Aguilera, Marta Alvarez, Juan Carlos Galán, Federico García   +12 more
doaj   +1 more source

Comparison of the docking poses with NS3 proteases from sub-genotype 1a and 1b.

, 2013
(A) Docking poses of 12 colored in pink with the sub-genotype 1b NS3 protease (colored in tan). Compound 12 is colored in cyan when it was docked with the sub-genotype 1a NS3 protease (colored in cyan).
Susan L. Uprichard (261305), Tian Zhu (394135), Kavankumar Patel (468714), Joseph L. Gatuz (468718), Kirk E. Hevener (468717), Yan-Yan Zhang (468715), Lena Truong (468716), Gitanjali Subramanya (468719), Michael E. Johnson (468721), Hyun Lee (468713), Hyun-Young Jeong (468720)   +10 more
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source