Results 81 to 90 of about 706,514 (296)
, 1997 The viral genotype may influence the response to interferon (IFN) treatment in chronic hepatitis C virus (HCV) infection. To characterize potential mechanisms responsible for this effect, we assessed whether IFN modulation of HCV-specific T-cell ...
Miyamura, T +10 more
core +1 more source
Persistent growth of a human plasma-derived hepatitis C virus genotype 1b isolate in cell culture. [PDF]
, 2010 HCV (hepatitis C virus) research, including therapeutics and vaccine development, has been hampered by the lack of suitable tissue culture models. Development of cell culture systems for the growth of the most drug-resistant HCV genotype (1b) as well as ...
Plant Ewan P. +19 more
core +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Genótipos do VHC. Histopatologia hepática e perfil imunológico em quatro grupos de doentes.
Acta Médica Portuguesa, 2000 Study on the prevalence of MCV genotypes, and correlation with liver pathology and immunological parameters.77 chronic hepatitis C patients (52 males, 25 females), mean age 44 +/- 14 years, belonging to four groups: (1) 23 (11 males) without other ...
A De Carvalho +5 more
doaj +1 more source
The mutant spectrum for HCV genotype 1b.
, 2019 (A) The time-evolution of population of virions carrying different codons, color coded by the amino acids they encode. (B) The mutational pathway map with CGG, the wild-type codon for HCV genotype 1b at position 155 of the NS3 protein, as the founder ...
Narendra M. Dixit (135562) +3 more
core +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
PLoS ONE, 2016 We aimed to evaluate the correct assignment of HCV genotypes by three commercial methods-Trugene HCV genotyping kit (Siemens), VERSANT HCV Genotype 2.0 assay (Siemens), and Real-Time HCV genotype II (Abbott)-compared to NS5B sequencing.
Natalia Chueca +12 more
doaj +1 more source
Inhibitory effects of caffeic acid phenethyl ester derivatives on replication of hepatitis C virus. [PDF]
PLoS ONE, 2013 Caffeic acid phenethyl ester (CAPE) has been reported as a multifunctional compound. In this report, we tested the effect of CAPE and its derivatives on hepatitis C virus (HCV) replication in order to develop an effective anti-HCV compound. CAPE and CAPE
Hui Shen +15 more
doaj +1 more source
CYP3A5*3, CYP3A4*1B and MDR1 C3435T Genotype Distributions in Ecuadorians [PDF]
Disease Markers, 2008 Polymorphisms in CYP3A genes, such as CYP3A5 and CYP3A4, as well as in the MDR1 gene, which encodes for P‐glycoprotein, have been implicated as genetic markers in several disorders. Differences in the frequency distribution of the allelic variants CYP3A5*3, CYP3A4*1B, and MDR1 3435T have been demonstrated between distinct ethnic groups.
Sinués, Blanca +6 more
openaire +2 more sources
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source