Results 61 to 70 of about 263,661 (293)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The Real-World Safety and Efficacy of Daclatasvir and Asunaprevir for Elderly Patients

Gut and Liver, 2018
Background/AimsAlthough daclatasvir with asunaprevir was approved in Japan for interferon ineligible or intolerant patients, patients aged ≥75 years were excluded in the phase III trial. The present study aimed to evaluate the safety and efficacy of this
Shinya Taki, Hideyuki Tamai, Yoshiyuki Ida, Naoki Shingaki, Akira Kawashima, Ryo Shimizu, Kosaku Moribata, Takao Maekita, Mikitaka Iguchi, Jun Kato, Taisei Nakao, Masayuki Kitano   +11 more
doaj   +1 more source

The cobas® HCV GT is a new tool that accurately identifies Hepatitis C virus genotypes for clinical practice. [PDF]

PLoS ONE, 2017
OBJECTIVE:We aimed to evaluate the correct assignment of HCV genotype/subtypes 1a and 1b by cobas® HCV genotyping (GT) assay (Roche Molecular Diagnostics) compared with nonstructural protein 5B (NS5B) sequencing.
J A Fernández-Caballero, M Alvarez, N Chueca, A B Pérez, F García   +4 more
doaj   +1 more source

Various triazine compounds exhibit broad activity against HCV genotype 1a and 1b strains.

, 2012
Various triazine compounds exhibit broad activity against HCV genotype 1a and 1b strains.
Danielle N. Fisch (168724), Amy Q. Han (168783), Paul J. Maddon (168796), Yakov Rotshteyn (168776), Sameer M. Moorji (168734), Dapeng Qian (168791), Jean-Marc de Muys (168744), Jose D. Murga (168753), Glen A. Coburn (168717), Dorothy Paul (168761), Kathleen P. Provoncha (168769), William C. Olson (128917)   +11 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Predictors of treatment response in patients with hepatitis C 1b genotype

Open Medicine, 2013
Abstract
Brjalin Vadim, Salupere Riina, Tallo Tatjana, Kuznetsova Tatiana, Priimägi Ljudmilla, Tefanova Valentina   +5 more
openaire   +2 more sources

Evaluation of Paraoxonase 1 Activities in Patients Infected with Hepatitis C Virus Genotype 1b and Genotype 4 in the Kayseri Province of Turkey

, 2015
Objective: Hepatitis C virus (HCV) infection is an important cause of chronic liver disease and is associated with oxidative stress. The type of treatment given for chronic HCV infection depends on the genotype of the virus.
KARAKÜKCÜ, ÇİĞDEM, Karaman, Hatice, Karaman, Ahmet, Kocer, Derya, Yaman, OZAN, Godekmerdan, Ahmet, Sariguzel, FATMA   +6 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Pre-Existing HCV Variants Resistant to DAAs and Their Sensitivity to PegIFN/RBV in Chinese HCV Genotype 1b Patients. [PDF]

PLoS One, 2016
BackgroundThe efficacy of direct-acting antiviral agents (DAAs) could be attenuated by the presence of resistance-associated variants (RAVs). The aim of this study was to investigate the natural prevalence of RAVs among Chinese HCV genotype 1b patients ...
Zhang Y, Cao Y, Zhang R, Zhang X, Lu H, Wu C, Huo N, Xu X.   +7 more
europepmc   +2 more sources