Results 61 to 70 of about 706,514 (296)

Scheme illustrating the antagonism between HCV genotype 1b replication and PER2 in hepatocytes.

, 2013
HCV core protein genotype 1b, via a yet undefined mechanism, induces a downregulation of PER2 mRNA. PER2 protein produced in the cytoplasm accumulates in the nucleus, as observed in human liver biopsies infected with HCV genotype 1b, where could further ...
Roger Williams (287293), Francesca Rappa (55683), Azzura Greco (287286), Francesco Cappello (55681), Giorgia Benegiamo (400654), Manlio Vinciguerra (287299), Valerio Pazienza (174196), Gianluigi Mazzoccoli (174205), Nunzia Scibetta (287291), Jude Oben (400655), Angelo Andriulli (174277)   +10 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Six-year distribution pattern of hepatitis C virus in Turkey: a multicentre study

Biotechnology & Biotechnological Equipment, 2016
Hepatitis C infection is a public health problem. The aim of this retrospective study was to determine the distribution of hepatitis C virus (HCV) genotypes in seven regions of Turkey, by evaluating 7002 patients with chronic HCV in a six-year period ...
Mustafa Altindis, Tuba Dal, Isin Akyar, Onur Karatuna, Selma Gokahmetoglu, Seda Tezcan Ulger, Canan Kulah, Berrin Uzun, Aslı Gamze Şener, Mehmet Ozdemir, Sibel Aydogan, Mert Ahmet Kuskucu, Kenan Midilli, Baris Otlu, Mustafa Kemal Celen, Kurtulus Buruk, Huseyin Guducuoglu   +16 more
doaj   +1 more source

Estrogen Receptor Alpha Expression and Liver Fibrosis in Chronic Hepatitis C Virus Genotype 1b: A Clinicopathological Study

, 2014
Background: Hepatic damage due to chronic hepatitis C virus (HCV) genotype 1b infection varies ...
Guldal Yılmaz, Mustafa Cengiz, Cengiz, Mustafa, Ozenirler, Seren, Seren Ozenirler, Yilmaz, Guldal   +5 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Hepatitis C virus genotype and its correlation with viral load in patients from Kathmandu, Nepal

Journal of Infection in Developing Countries, 2020
Introduction: Knowledge about the distribution of hepatitis C virus (HCV) genotype and its correlation with viral load are important for the decision of treatment and the prediction of disease progression, however such information is very limited in ...
Bhavesh Kumar Mishra, Uday Narayan Yadav, Saroj Khatiwada, Man Kumar Tamang, Shivir Dahal, Yi-Ping Li   +5 more
doaj   +1 more source

The cobas® HCV GT is a new tool that accurately identifies Hepatitis C virus genotypes for clinical practice. [PDF]

PLoS ONE, 2017
OBJECTIVE:We aimed to evaluate the correct assignment of HCV genotype/subtypes 1a and 1b by cobas® HCV genotyping (GT) assay (Roche Molecular Diagnostics) compared with nonstructural protein 5B (NS5B) sequencing.
J A Fernández-Caballero, M Alvarez, N Chueca, A B Pérez, F García   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The Real-World Safety and Efficacy of Daclatasvir and Asunaprevir for Elderly Patients

Gut and Liver, 2018
Background/AimsAlthough daclatasvir with asunaprevir was approved in Japan for interferon ineligible or intolerant patients, patients aged ≥75 years were excluded in the phase III trial. The present study aimed to evaluate the safety and efficacy of this
Shinya Taki, Hideyuki Tamai, Yoshiyuki Ida, Naoki Shingaki, Akira Kawashima, Ryo Shimizu, Kosaku Moribata, Takao Maekita, Mikitaka Iguchi, Jun Kato, Taisei Nakao, Masayuki Kitano   +11 more
doaj   +1 more source

Clinical characteristics of 702 patients infected with HCV genotype 1b included in the study.

, 2015
a Data were compared by Student's t-test or chi-square test as appropriate.Clinical characteristics of 702 patients infected with HCV genotype 1b included in the study.
Hiroshi Aikata (128663), Eisuke Murakami (756173), Daiki Miki (128628), Kazuaki Chayama (128675), Hidenori Ochi (128649), Michio Imamura (128656), Satoshi Yoshimi (756172), C. Nelson Hayes (128614), Sakura Akamatsu (128618), Hiromi Kan (756175), Takuro Uchida (756174), Nobuhiko Hiraga (128653), Hiromi Abe (128643)   +12 more
core   +1 more source