Results 51 to 60 of about 263,661 (293)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Prevalence of Hepatitis C Virus Genotypes in Mashhad, North-east Iran [PDF]
Iranian Journal of Public Health, 2012 Background: Hepatitis C is a disease with significant global impact. The distribution of hepatitis C virus (HCV) genotypes in Mashhad (the Northeast and the biggest city after the capital of Iran) is unknown.
H Nomani +10 more
doaj +2 more sources
Prevalence of NS5B Polymerase Inhibitor Resistance Mutations in Genotype 1b Patients.
, 2016 Prevalence of NS5B Polymerase Inhibitor Resistance Mutations in Genotype 1b Patients.
Chihong Wu (3331833) +7 more
core +1 more source
Quantitation of substitutions at amino acid 70 in hepatitis C virus genotype 1b [PDF]
Virology Journal, 2014 Substitutions of amino acid (aa) 70 in the core region of hepatitis C virus genotype 1b (HCV 1b) are a predictor of the non-virological response to pegylated interferon plus ribavirin (PEG-IFN/RBV) therapy. The aim of our study was to develop quantitative real-time reverse transcription polymerase chain reaction (qPCR) assays to quantify wild-type (70 ...
Hu, Zhongjie +6 more
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Prevalence of NS3 Protease Inhibitor Resistance Mutations in Genotype 1b Patients.
, 2016 Prevalence of NS3 Protease Inhibitor Resistance Mutations in Genotype 1b Patients.
Chihong Wu (3331833) +7 more
core +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Six-year distribution pattern of hepatitis C virus in Turkey: a multicentre study
Biotechnology & Biotechnological Equipment, 2016 Hepatitis C infection is a public health problem. The aim of this retrospective study was to determine the distribution of hepatitis C virus (HCV) genotypes in seven regions of Turkey, by evaluating 7002 patients with chronic HCV in a six-year period ...
Mustafa Altindis +16 more
doaj +1 more source
Hepatitis C virus genotype and its correlation with viral load in patients from Kathmandu, Nepal
Journal of Infection in Developing Countries, 2020 Introduction: Knowledge about the distribution of hepatitis C virus (HCV) genotype and its correlation with viral load are important for the decision of treatment and the prediction of disease progression, however such information is very limited in ...
Bhavesh Kumar Mishra +5 more
doaj +1 more source
Amplification and Sequencing Primers for HCV NS3, NS5A and NS5B in Genotype 1b Patients.
, 2016 Amplification and Sequencing Primers for HCV NS3, NS5A and NS5B in Genotype 1b Patients.
Chihong Wu (3331833) +7 more
core +1 more source