Results 41 to 50 of about 263,661 (293)

Contribution of Cyclin-dependent Kinase Inhibitor 1B Genotypes to Childhood Leukemia Risk

In Vivo, 2022
Although genetic differences in cell-cycle control genes have been associated with cancer risk, to our knowledge, no report has specifically examined the role of gene variants in childhood acute lymphoblastic leukemia (ALL). Cyclin-dependent kinase inhibitor 1B (CDKN1B; also known as p27/KIP1) is a cell-cycle regulating gene.
Jen-Sheng, Pei, Wen-Shin, Chang, Pei-Chen, Hsu, Chao-Chun, Chen, Ya-Chen, Yang, Shih-Wei, Hsu, Yuan-Nian, Hsu, Yun-Chi, Wang, Chung-Hsing, Wang, Chia-Wen, Tsai, DA-Tian, Bau   +10 more
openaire   +2 more sources

Association of CYP3A4 and CYP3A5 polymorphisms with Iranian breast cancer patients

Egyptian Journal of Medical Human Genetics, 2015
Background: Polymorphisms of different gene have been reported to be associated with cancer including breast cancer. Hospitalization rate for breast cancer has increased over the years in Iran.
Elham Badavi, Babak Safavi, Amir Jalali, Ghazaleh Mohammadzadeh Shahriary, Javad Mohammadi-Asl, Javad Babaei   +5 more
doaj   +1 more source

Hepatitis C Virus Genotyping: Interrogation of the 5′ Untranslated Region Cannot Accurately Distinguish Genotypes 1a and 1b [PDF]

Journal of Clinical Microbiology, 2002
ABSTRACT Although the 5′ untranslated region (5′ UTR) is the most conserved region of the hepatitis C virus (HCV) genome, it has been suggested that interrogation of this region is sufficient for determination of the HCV genotype. We compared two methods of determination of the HCV genotype: (i) direct sequencing of the DNA of the NS-5b ...
Zhenyu, Chen, Karen E, Weck
openaire   +2 more sources

Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview

American Journal of Obstetrics and Gynecology, 2007
Fetal alcohol syndrome (FAS), 1 of the most common developmental disabilities in the United States, occurs at a rate of 0.5-2.0:1000 live births. Animal model, family, and twin studies suggest a genetic component to FAS susceptibility. Alcohol dehydrogenases (ADHs) catalyze the rate-limiting step in alcohol metabolism.
Green, Ridgely Fisk, Stoler, Joan Marilyn   +1 more
openaire   +2 more sources

Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials

, 2012
Background: In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased sustained virologic response (SVR) rates compared with PR alone.
Bambang Adiwijaya, Joan Spanks, Ann Tigges (171451), Ann Tigges, Joan Spanks (171460), Zhang Eileen Z., Maria Beumont, Bartels Doug J., De Meyer, Sandra, Jacobson, Ira M., Ira M. Jacobson (171497), Kieffer Tara L., Ghys Anne, Min Jiang, Sullivan James C., James C Sullivan, Doug J Bartels, Beumont, Maria, Dorrian Jennifer, Dierynck, Inge, Nathalie Adda, Adiwijaya, Bambang, Kauffman, Robert S., Kwong, Ann D., Min Jiang (56794), Jennifer Dorrian (171464), James C. Sullivan (13811), Bambang Adiwijaya (171470), Sherman, Kenneth E., Dierynck Inge, Ann D. Kwong (171515), Ghys, Anne, Tara L Kieffer, Gaston Picchio, Maria Beumont (171481), Spanks Joan, Inge Dierynck, Kenneth E Sherman, Robert S Kauffman, Adda Nathalie, Sherman Kenneth E., Stefan Zeuzem (22856), Stefan Zeuzem, Inge Dierynck (171456), Jiang, Min, Robert S. Kauffman (171487), Gaston Picchio (171523), Kwong Ann D., Zhang, Eileen Z., Sandra De Meyer (171427), Tigges, Ann, Zeuzem Stefan, Dorrian, Jennifer, Kenneth E. Sherman (171505), Sandra De Meyer, Nathalie Adda (171493), Jacobson Ira M., Adiwijaya Bambang, Ira M Jacobson, Bartels, Doug J., Doug J. Bartels (171434), Eileen Z Zhang, Jennifer Dorrian, De Meyer Sandra, Tigges Ann, Sullivan, James C., Picchio, Gaston, Ann D Kwong, Anne Ghys (171476), Adda, Nathalie, Eileen Z. Zhang (171445), Kieffer, Tara L., Spanks, Joan, Picchio Gaston, Kauffman Robert S., Anne Ghys, Tara L. Kieffer (171419), Jiang Min, Zeuzem, Stefan, Beumont Maria   +79 more
core   +1 more source

Prevalence of NS5A Inhibitor Resistance Mutations in Genotype 1b Patients.

, 2016
Prevalence of NS5A Inhibitor Resistance Mutations in Genotype 1b Patients.
Chihong Wu (3331833), Renwen Zhang (283472), Yu Zhang (12946), Na Huo (573856), Xiaxia Zhang (3331836), Xiaoyuan Xu (114688), Haiying Lu (511961), Ying Cao (170160)   +7 more
core   +1 more source

Epidemiology and Genotype Distribution of Hepatitis C Virus in Russia

Pathogens, 2022
The hepatitis C virus (HCV) causes both acute and chronic infection of the liver that can lead to liver cirrhosis, cancer, and liver failure. HCV is characterized by high genetic diversity and substantial variations in the prevalence of specific HCV ...
Nikolay Pimenov, Dmitry Kostyushev, Svetlana Komarova, Anastasia Fomicheva, Alexander Urtikov, Olga Belaia, Karina Umbetova, Olga Darvina, Natalia Tsapkova, Vladimir Chulanov   +9 more
doaj   +1 more source

Scheme illustrating the antagonism between HCV genotype 1b replication and PER2 in hepatocytes.

, 2013
HCV core protein genotype 1b, via a yet undefined mechanism, induces a downregulation of PER2 mRNA. PER2 protein produced in the cytoplasm accumulates in the nucleus, as observed in human liver biopsies infected with HCV genotype 1b, where could further ...
Roger Williams (287293), Francesca Rappa (55683), Azzura Greco (287286), Francesco Cappello (55681), Giorgia Benegiamo (400654), Manlio Vinciguerra (287299), Valerio Pazienza (174196), Gianluigi Mazzoccoli (174205), Nunzia Scibetta (287291), Jude Oben (400655), Angelo Andriulli (174277)   +10 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The distribution of hepatitis C virus genotypes in patients with hepatocellular carcinoma

Asian Journal of Medical Sciences, 2019
Background: Hepatic cirrhosis develops within 20-30 years in approximately 20% of individuals chronically infected with hepatitis C virus (HCV). Aims and Objective: This study aimed to determine the distribution of HCV genotypes in patients with HCV ...
Ayfer Bakır, Nuran Karabulut , Sema Alaçam, Barış Bakır , Ali Ağaçfidan   +4 more
doaj   +1 more source