Results 21 to 30 of about 263,661 (293)

Does the melatonin receptor 1B gene polymorphism have a role in postoperative delirium? [PDF]

PLoS ONE, 2018
INTRODUCTION:Patients undergoing cardiac surgery are at high risk for postoperative delirium, which is associated with longer hospital and intensive care lengths of stays, increased morbidity and mortality.
Elizabeth Mahanna-Gabrielli, Todd A Miano, John G Augoustides, Cecilia Kim, Joseph E Bavaria, W Andrew Kofke   +5 more
doaj   +1 more source

Genotype distribution in chronic hepatitis C, relationship of genotype with HCV RNA, alpha fetoprotein, alanine aminotransferase and liver fibrosis

Medicine Science, 2021
In this study, the genotype distribution in chronic hepatitis C (CHC) and its relationship with alanine aminotransferase (ALT), alpha fetoprotein (AFP), HCV RNA and liver fibrosis were compared. HCV RNA was negative in 63 and positive in 69 CHC cases who
Arzu Senol, Ozlem Aytac
doaj   +1 more source

Replication and infectivity of a novel genotype 1b hepatitis C virus clone [PDF]

Microbiology and Immunology, 2012
ABSTRACT Hepatitis C virus infection is a major public health problem because of an estimated 170 million carriers worldwide. Genotype 1b is the major subtype of HCV in many countries and is resistant to interferon therapy. Study of the viral life cycle is important for understanding the mechanisms of interferon resistance of genotype 1b HCV strains ...
Tomoko, Date, Kenichi, Morikawa, Yasuhito, Tanaka, Keiko, Tanaka-Kaneko, Tetsutaro, Sata, Masashi, Mizokami, Takaji, Wakita   +6 more
openaire   +2 more sources

An infectious molecular clone of a Japanese genotype 1b hepatitis C virus [PDF]

Hepatology, 1999
We describe an infectious molecular clone of a Japanese genotype 1b strain of hepatitis C virus (HCV-N). The molecularly cloned sequence of HCV-N was compared with alignments of other HCV sequences, leading to the identification of 15 unique, nonconservative amino acid substitutions within the HCV-N open reading frame (ORF ...
M R, Beard, G, Abell, M, Honda, A, Carroll, M, Gartland, B, Clarke, K, Suzuki, R, Lanford, D V, Sangar, S M, Lemon   +9 more
openaire   +2 more sources

Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2013
The discovery of potent thienoimidazole-based HCV NS5A inhibitors is herein reported. A novel method to access the thienoimidazole [5,5]-bicyclic system is disclosed. This method gave access to a common key intermediate (6) that was engaged in Suzuki or Sonogashira reactions with coupling partners bearing different linkers.
Simon, Giroux, Jinwang, Xu, T Jagadeeswar, Reddy, Mark, Morris, Kevin M, Cottrell, Caroline, Cadilhac, James A, Henderson, Oliver, Nicolas, Darius, Bilimoria, Francois, Denis, Nagraj, Mani, Nigel, Ewing, Rebecca, Shawgo, Lucille, L'Heureux, Subajini, Selliah, Laval, Chan, Nathalie, Chauret, Francoise, Berlioz-Seux, Mark N, Namchuk, Anne-Laure, Grillot, Youssef L, Bennani, Sanjoy K, Das, John P, Maxwell   +22 more
openaire   +2 more sources

Direct Acting Antiviral Agents in Korean Patients with Chronic Hepatitis C and Hemophilia Who Are Treatment-Naïve or Treatment-Experienced

Gut and Liver, 2017
Background/AimsChronic hepatitis C (CHC) is a major comorbidity in patients with hemophilia.Methods : Patients (n=30) were enrolled between September 2015 and April 2016.
Hyun Woong Lee, Ki Young Yoo, Joung Won Won, Hyung Joon Kim   +3 more
doaj   +1 more source

Next-generation sequencing analysis of hepatitis C virus resistance–associated substitutions in direct-acting antiviral failure in South Korea [PDF]

Clinical and Molecular Hepatology, 2023
Background/Aims We used next-generation sequencing (NGS) to analyze resistance-associated substitutions (RASs) and retreatment outcomes in patients with chronic hepatitis C virus (HCV) infection who failed direct-acting antiviral agent (DAA) treatment in
Kyung-Ah Kim, Sejoon Lee, Hye Jung Park, Eun Sun Jang, Youn Jae Lee, Sung Bum Cho, Young Suk Kim, In Hee Kim, Byung Seok Lee, Woo Jin Chung, Sang Hoon Ahn, Seungtaek Kim, Sook Hyang Jeong   +12 more
doaj   +1 more source

An impact of CYP3A4 *1B polymorphism on rifampicin metabolism

Journal of Education, Health and Sport, 2017
Until now, the enzyme systems responsible for biotransformation of the antituberculous drug rifampicin remain unknown. The aim of research was an investigation of the candidate enzymes involved in the biotransformation of rifampicin using the computer ...
H. O. Poludenko, P. B. Antonenko
doaj   +3 more sources

Genomic characterization of Brazilian hepatitis C virus genotypes 1a and 1b [PDF]

Brazilian Journal of Medical and Biological Research, 1997
Parts of 5' non-coding (5' NC) and of E1 envelope regions of the hepatitis C virus (HCV) genome were amplified from sera of 26 Brazilian anti-HCV antibody-positive patients using the reverse transcription-polymerase chain reaction (RT-PCR). Fourteen samples were PCR positive with primers from the 5' NC region and 8 of them were also positive with ...
M.G. Peig Ginabreda, C.F.T. Yoshida, C. Niel   +2 more
openaire   +3 more sources

Genotype Distribution and Molecular Epidemiology of Hepatitis C Virus in Guangzhou, China: Predominance of Genotype 1b and Increasing Incidence of Genotype 6a [PDF]

Cellular Physiology and Biochemistry, 2017
Background/Aims: Distribution of Hepatitis C virus (HCV) genotypes vary geographically and may associate with the mode of transmission. Little is known about the molecular epidemiology of HCV infection in Guangzhou, China. Methods: A cross-sectional survey included 561 subjects with chronic HCV infection registered at Nanfang Hospital, Southern Medical
Guosheng Yuan, Junwei Liu, Chengguang Hu, Huaping Huang, Minghua Qi, Tao Wu, Weifang Liang, Yi-Ping Li, Yong-Yuan Zhang, Yuanping Zhou   +9 more
openaire   +3 more sources