Results 21 to 30 of about 706,514 (296)

Steatohepatitis is associated with diabetes and fibrosis in genotype 1b HCV‐related chronic liver disease

Journal of Viral Hepatitis, 2007
Summary.  Liver steatosis, diabetes mellitus and hepatitis C virus (HCV) genotype have been implicated in liver fibrosis in HCV‐related chronic active hepatitis (CAH). The aim of this study was to evaluate whether steatosis and diabetes were associated with more severe liver fibrosis in patients with genotype 1b HCV‐related CAH.
MASARONE, MARIO, La Mura V, Bruno S, Gaeta GB, Vecchione R, Carrino F, Moschella F, Torella R, PERSICO, Marcello   +8 more
openaire   +7 more sources

Efficient Hepatitis C Virus Genotype 1b Core-NS5A Recombinants Permit Efficacy Testing of Protease and NS5A Inhibitors. [PDF]

Antimicrob Agents Chemother, 2017
Hepatitis C virus (HCV) strains belong to seven genotypes with numerous subtypes that respond differently to antiviral therapies. Genotype 1, and primarily subtype 1b, is the most prevalent genotype worldwide.
Pham LV, Ramirez S, Carlsen THR, Li YP, Gottwein JM, Bukh J.   +5 more
europepmc   +2 more sources

Replication and infectivity of a novel genotype 1b hepatitis C virus clone [PDF]

Microbiology and Immunology, 2012
ABSTRACT Hepatitis C virus infection is a major public health problem because of an estimated 170 million carriers worldwide. Genotype 1b is the major subtype of HCV in many countries and is resistant to interferon therapy. Study of the viral life cycle is important for understanding the mechanisms of interferon resistance of genotype 1b HCV strains ...
Tomoko, Date, Kenichi, Morikawa, Yasuhito, Tanaka, Keiko, Tanaka-Kaneko, Tetsutaro, Sata, Masashi, Mizokami, Takaji, Wakita   +6 more
openaire   +2 more sources

An infectious molecular clone of a Japanese genotype 1b hepatitis C virus [PDF]

Hepatology, 1999
We describe an infectious molecular clone of a Japanese genotype 1b strain of hepatitis C virus (HCV-N). The molecularly cloned sequence of HCV-N was compared with alignments of other HCV sequences, leading to the identification of 15 unique, nonconservative amino acid substitutions within the HCV-N open reading frame (ORF ...
M R, Beard, G, Abell, M, Honda, A, Carroll, M, Gartland, B, Clarke, K, Suzuki, R, Lanford, D V, Sangar, S M, Lemon   +9 more
openaire   +2 more sources

Discovery of Thienoimidazole-Based HCV NS5A Genotype 1a and 1b Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2013
The discovery of potent thienoimidazole-based HCV NS5A inhibitors is herein reported. A novel method to access the thienoimidazole [5,5]-bicyclic system is disclosed. This method gave access to a common key intermediate (6) that was engaged in Suzuki or Sonogashira reactions with coupling partners bearing different linkers.
Simon, Giroux, Jinwang, Xu, T Jagadeeswar, Reddy, Mark, Morris, Kevin M, Cottrell, Caroline, Cadilhac, James A, Henderson, Oliver, Nicolas, Darius, Bilimoria, Francois, Denis, Nagraj, Mani, Nigel, Ewing, Rebecca, Shawgo, Lucille, L'Heureux, Subajini, Selliah, Laval, Chan, Nathalie, Chauret, Francoise, Berlioz-Seux, Mark N, Namchuk, Anne-Laure, Grillot, Youssef L, Bennani, Sanjoy K, Das, John P, Maxwell   +22 more
openaire   +2 more sources

An impact of CYP3A4 *1B polymorphism on rifampicin metabolism

Journal of Education, Health and Sport, 2017
Until now, the enzyme systems responsible for biotransformation of the antituberculous drug rifampicin remain unknown. The aim of research was an investigation of the candidate enzymes involved in the biotransformation of rifampicin using the computer ...
H. O. Poludenko, P. B. Antonenko
doaj   +3 more sources

Genomic characterization of Brazilian hepatitis C virus genotypes 1a and 1b [PDF]

Brazilian Journal of Medical and Biological Research, 1997
Parts of 5' non-coding (5' NC) and of E1 envelope regions of the hepatitis C virus (HCV) genome were amplified from sera of 26 Brazilian anti-HCV antibody-positive patients using the reverse transcription-polymerase chain reaction (RT-PCR). Fourteen samples were PCR positive with primers from the 5' NC region and 8 of them were also positive with ...
M.G. Peig Ginabreda, C.F.T. Yoshida, C. Niel   +2 more
openaire   +3 more sources

Next-generation sequencing analysis of hepatitis C virus resistance–associated substitutions in direct-acting antiviral failure in South Korea [PDF]

Clinical and Molecular Hepatology, 2023
Background/Aims We used next-generation sequencing (NGS) to analyze resistance-associated substitutions (RASs) and retreatment outcomes in patients with chronic hepatitis C virus (HCV) infection who failed direct-acting antiviral agent (DAA) treatment in
Kyung-Ah Kim, Sejoon Lee, Hye Jung Park, Eun Sun Jang, Youn Jae Lee, Sung Bum Cho, Young Suk Kim, In Hee Kim, Byung Seok Lee, Woo Jin Chung, Sang Hoon Ahn, Seungtaek Kim, Sook Hyang Jeong   +12 more
doaj   +1 more source

Distribution of Hepatitis C Virus Genotypes in the Region of İstanbul Northern Anatolian Association of Public Hospitals

Viral Hepatitis Journal, 2017
ObjectiveHepatitis C virus (HCV) is responsible for 20% of acute hepatitis and 70% of chronic hepatitis. Determination of HCV genotype is important in the regulation of treatment and the followup of clinical course.
Ülkü ORAL ZEYTİNLİ, Fatma MUHTEREM YÜCEL, Şölen DALDABAN DİNÇER, Özgür YANILMAZ, Sebahat AKSARAY, Kamil ÖZDİL   +5 more
doaj   +1 more source

The prevalence of mixed genotype infections in Polish patients with hepatitis C

International Journal of Infectious Diseases, 2016
Objectives: Hepatitis C virus (HCV) genotype has been described as an independent predictor of the response to therapy. A mixed infection with two types of HCV is probably an uncommon event.
Ewelina Gowin, Iwona Bereszyńska, Agnieszka Adamek, Arleta Kowala-Piaskowska, Iwona Mozer-Lisewska, Jacek Wysocki, Michał Michalak, Danuta Januszkiewicz-Lewandowska   +7 more
doaj   +1 more source