Results 31 to 40 of about 706,514 (296)

Genotype Distribution and Molecular Epidemiology of Hepatitis C Virus in Guangzhou, China: Predominance of Genotype 1b and Increasing Incidence of Genotype 6a [PDF]

Cellular Physiology and Biochemistry, 2017
Background/Aims: Distribution of Hepatitis C virus (HCV) genotypes vary geographically and may associate with the mode of transmission. Little is known about the molecular epidemiology of HCV infection in Guangzhou, China. Methods: A cross-sectional survey included 561 subjects with chronic HCV infection registered at Nanfang Hospital, Southern Medical
Guosheng Yuan, Junwei Liu, Chengguang Hu, Huaping Huang, Minghua Qi, Tao Wu, Weifang Liang, Yi-Ping Li, Yong-Yuan Zhang, Yuanping Zhou   +9 more
openaire   +3 more sources

Genotype-specific versus pangenotypic regimens in patients infected with HCV genotype 1b in real-world settings [PDF]

Polish Archives of Internal Medicine, 2021
Introduction The introduction of direct-acting antivirals (DAA) has provided us with hope to eliminate hepatitis C virus (HCV) infection as a significant public health problem in the coming years. Objective Our study aimed to compare the effectiveness and safety between genotype-specific and pangenotypic regimens in GT1b infected patients treated in
Paweł Pabjan, Michał Brzdęk, Magdalena Chrapek, Kacper Dziedzic, Piotr M. Stępień, Katarzyna Paluch, Anna Garbat, Piotr Błoniarczyk, Katarzyna Reczko, Dorota Zarębska-Michaluk   +9 more
openaire   +1 more source

CYTOPENIAS AND THEIR CORRECTION DURING ANTIVIRAL THERAPY OF CHRONIC HEPATITIS C IN PATIENTS WITH GENOTYPE 1

Вопросы вирусологии, 2017
The main reason for the ineffectiveness of antiviral therapy in patients with chronic hepatitis C that impedes full and adequate treatment of IFN-α and ribavirin is the development of neutropenia and thrombocytopenia.
E. R. Manapova, V. Ch. Fazylov, S. V. Guryanova   +2 more
doaj   +1 more source

The role of different virus genotypes in progression of chronic hepatitis C [PDF]

Vojnosanitetski Pregled, 2002
The relation between HCV genotypes and the progression of chronic hepatitis is still unknown. Some studies implied more pathogenic effect of genotype 1b for the severity of liver inflammation.
Nožić Darko, Stamenković Gorana, Bojić Ivanko, Dimitrijević Jovan, Krstić Ljubiša   +4 more
doaj   +1 more source

Hepatitis C virus genotype 1b chimeric replicon containing genotype 3 NS5A domain

Virology, 2006
Infections with hepatitis C virus (HCV) genotype 3 exhibit differences in clinical phenotype including an increase in response to interferon therapy and development of steatosis. To initiate studies on genotype 3, we created a chimeric genotype 1b replicon containing a genotype 3a NS5A domain. The chimera was capable of efficient colony formation after
Lanford, Robert E., Guerra, Bernadette, Lee, Helen   +2 more
openaire   +2 more sources

Distribution of Hepatitis C Virus Genotypes in Aydın Province

Viral Hepatitis Journal, 2018
Objectives: In this study, we evaulated the distribution and alteration of hepatitis C virus (HCV) genotypes throughout years which has a clinical importance in the treatment and follow-up.Materials and Methods: Test results obtained from blood samples ...
Yasin TİRYAKİ, Alev ÇETİN DURAN, Osman Olcay ÖZÇOLPAN   +2 more
doaj   +1 more source

Challenges to Differentiate Hepatitis C Genotype 1 and 6: Results from A Field-Study in Cambodia

Infectious Diseases and Therapy, 2020
Introduction We aim to report on results and challenges of different methods used for hepatitis C (HCV) genotyping in a Cambodian HCV/HIV coinfection project. Methods Samples of 106 patients were available.
Anja De Weggheleire, Irith De Baetselier, Sokkab An, Sylvie Goletti, Vanessa Suin, Sopheak Thai, Sven Francque, Tania Crucitti, Lutgarde Lynen, Steven Van Gucht, Benoît Mukadi Kabamba   +10 more
doaj   +1 more source

Study on the relationship between SLCO1B1 and ApoE gene polymorphisms and the risk of coronary heart disease in the Mongolian population

Clinical and Experimental Hypertension, 2021
Objective This study aimed to analyze the influence of SLCO1B1 and APOE gene polymorphisms on coronary heart disease in Mongolian population who living in Ordos area.
Rui-Bing Niu, Xiao-Xian Dong, Li-Ping Guo, Li Pan, Yue-Qin Hai, Xiao-Xiao Chen, Bao-Sheng Duan   +6 more
doaj   +1 more source

HCV non-1b genotypes in injecting drug users from Romania

The Journal of Infection in Developing Countries, 2016
Introduction: Chronic hepatitis C cases diagnosed in Romania were mostly related to unsafe parenteral treatments and blood transfusions; HCV genotype 1b was prevalent. During the last decade, an increasing number of HCV infections was reported among people who inject drugs (PWID).
Simona Ruta, Camelia Sultana, Cristiana Oprea, Codruta Vagu, Emanoil Ceausu, Costin Cernescu   +5 more
openaire   +4 more sources

Hepatitis C viral evolution in genotype 1 treatment-naïve and treatment-experienced patients receiving telaprevir-based therapy in clinical trials [PDF]

, 2012
Background: In patients with genotype 1 chronic hepatitis C infection, telaprevir (TVR) in combination with peginterferon and ribavirin (PR) significantly increased sustained virologic response (SVR) rates compared with PR alone.
Bambang Adiwijaya, Joan Spanks, Ann Tigges (171451), Ann Tigges, Joan Spanks (171460), Zhang Eileen Z., Maria Beumont, Bartels Doug J., De Meyer, Sandra, Jacobson, Ira M., Ira M. Jacobson (171497), Kieffer Tara L., Ghys Anne, Min Jiang, Sullivan James C., James C Sullivan, Doug J Bartels, Beumont, Maria, Dorrian Jennifer, Dierynck, Inge, Nathalie Adda, Adiwijaya, Bambang, Kauffman, Robert S., Kwong, Ann D., Min Jiang (56794), Jennifer Dorrian (171464), James C. Sullivan (13811), Bambang Adiwijaya (171470), Sherman, Kenneth E., Dierynck Inge, Ann D. Kwong (171515), Ghys, Anne, Tara L Kieffer, Gaston Picchio, Maria Beumont (171481), Spanks Joan, Inge Dierynck, Kenneth E Sherman, Robert S Kauffman, Adda Nathalie, Sherman Kenneth E., Stefan Zeuzem (22856), Stefan Zeuzem, Inge Dierynck (171456), Jiang, Min, Robert S. Kauffman (171487), Gaston Picchio (171523), Kwong Ann D., Zhang, Eileen Z., Sandra De Meyer (171427), Tigges, Ann, Zeuzem Stefan, Dorrian, Jennifer, Kenneth E. Sherman (171505), Sandra De Meyer, Nathalie Adda (171493), Jacobson Ira M., Adiwijaya Bambang, Ira M Jacobson, Bartels, Doug J., Doug J. Bartels (171434), Eileen Z Zhang, Jennifer Dorrian, De Meyer Sandra, Tigges Ann, Sullivan, James C., Picchio, Gaston, Ann D Kwong, Anne Ghys (171476), Adda, Nathalie, Eileen Z. Zhang (171445), Kieffer, Tara L., Spanks, Joan, Picchio Gaston, Kauffman Robert S., Anne Ghys, Tara L. Kieffer (171419), Jiang Min, Zeuzem, Stefan, Beumont Maria   +79 more
core   +1 more source