Hepatitis C virus genotype 1b chimeric replicon containing genotype 3 NS5A domain
Virology, 2006 Infections with hepatitis C virus (HCV) genotype 3 exhibit differences in clinical phenotype including an increase in response to interferon therapy and development of steatosis. To initiate studies on genotype 3, we created a chimeric genotype 1b replicon containing a genotype 3a NS5A domain. The chimera was capable of efficient colony formation after
Lanford, Robert E. +2 more
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HCV genotype 1a shows a better virological response to antiviral therapy than HCV genotype 1b [PDF]
BMC Gastroenterology, 2012 The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respond differently to treatment with PEGylated ...
Adriano M. Pellicelli +21 more
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Prevalence of hepatitis C virus subgenotypes 1a and 1b in Japanese patients: ultra-deep sequencing analysis of HCV NS5B genotype-specific region. [PDF]
PLoS ONE, 2013 BACKGROUND: Hepatitis C virus (HCV) subgenotypes 1a and 1b have different impacts on the treatment response to peginterferon plus ribavirin with direct-acting antivirals (DAAs) against patients infected with HCV genotype 1, as the emergence rates of ...
Shuang Wu +9 more
doaj +2 more sources
Cell culture replication of a genotype 1b hepatitis C virus isolate cloned from a patient who underwent liver transplantation. [PDF]
PLoS ONE, 2011 The introduction of the genotype 2a isolate JFH1 was a major breakthrough in the field of hepatitis C virus (HCV), allowing researchers to study the complete life cycle of the virus in cell culture.
George Koutsoudakis +8 more
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Seven-year Genotype Distribution Among Hepatitis C Patients in a City in the Central Anatolia Region of Turkey [PDF]
Viral Hepatitis Journal, 2018 Objectives:Hepatitis C virus (HCV) is an important viral agent of hepatitis, cirrhosis and hepatocellular carcinoma. In our study, we aimed to determine the HCV genotype distribution among patients with HCV who presented to our hospital in a city in the ...
Uğur TÜZÜNER +4 more
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Indian Journal of Dental Research, 2011 Introduction: The pro-inflammatory cytokine interleukin-1 (IL-1) is a key modulator of host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption, and polymorphisms in the IL-1 gene cluster have ...
R Gayathri +4 more
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Hepatitis C virus (HCV) genotype 1b displays higher genetic variability of hypervariable region 1 (HVR1) than genotype 3. [PDF]
Sci Rep, 2019 Hepatitis C virus (HCV) is characterized by high genetic variability, which is manifested both at the inter-host and intra-host levels. However, its role in the clinical course of infection is less obvious.
Janiak M +11 more
europepmc +2 more sources
Journal of International Medical Research, 2021 Objective To investigate the associations between interleukin (IL) gene polymorphisms and susceptibility to gastric cancer in the Qinghai population, China.
Xiaoyan Song +9 more
doaj +1 more source
Pathogens, 2021 Background and objective: Interleukins (ILs), as important biochemical mediators, control the host response to inflammation and are associated with bone resorption.
Hady Mohammadi +12 more
doaj +1 more source
Efficient Hepatitis C Virus Genotype 1b Core-NS5A Recombinants Permit Efficacy Testing of Protease and NS5A Inhibitors. [PDF]
Antimicrob Agents Chemother, 2017 Hepatitis C virus (HCV) strains belong to seven genotypes with numerous subtypes that respond differently to antiviral therapies. Genotype 1, and primarily subtype 1b, is the most prevalent genotype worldwide.
Pham LV +5 more
europepmc +2 more sources