Results 11 to 20 of about 706,514 (296)

Diagnosis of hepatitis C virus genotype 2k/1b needs NS5B sequencing [PDF]

International Journal of Infectious Diseases, 2015
Hepatitis C virus (HCV) is probably the most common cause of liver cirrhosis and hepatocellular carcinoma worldwide. The correct identification of HCV genotype has important clinical implications as a marker of responsiveness to antiviral therapy and ...
Steven De Keukeleire, Patrick Descheemaeker, Marijke Reynders   +2 more
doaj   +4 more sources

Seven-year Genotype Distribution Among Hepatitis C Patients in a City in the Central Anatolia Region of Turkey [PDF]

Viral Hepatitis Journal, 2018
Objectives:Hepatitis C virus (HCV) is an important viral agent of hepatitis, cirrhosis and hepatocellular carcinoma. In our study, we aimed to determine the HCV genotype distribution among patients with HCV who presented to our hospital in a city in the ...
Uğur TÜZÜNER, Begüm SARAN GÜLCEN, Mehmet ÖZDEMİR, Bahadır FEYZİOĞLU, Mahmut BAYKAN   +4 more
doaj   +2 more sources

HCV genotype 1a shows a better virological response to antiviral therapy than HCV genotype 1b [PDF]

BMC Gastroenterology, 2012
The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respond differently to treatment with PEGylated ...
Adriano M. Pellicelli, Mario Romano, Tommaso Stroffolini, Ettore Mazzoni, Fabrizio Mecenate, Roberto Monarca, Antonio Picardi, Maria Bonaventura, Cristina Mastropietro, Pascal Vignally, Arnaldo Andreoli, Massimo Marignani, Cecilia D'Ambrosio, Lucia Miglioresi, Lorenzo Nosotti, Olga Mitidieri, Umberto Gentilucci, Claudio Puoti, Giuseppe Barbaro, Angelo Barlattani, FURLAN, Caterina, G. Cleo Gorup Brbarini   +21 more
openaire   +6 more sources

NS4A protein as a marker of HCV history suggests that different HCV genotypes originally evolved from genotype 1b [PDF]

Virology Journal, 2011
Background The 9.6 kb long RNA genome of Hepatitis C virus (HCV) is under the control of RNA dependent RNA polymerase, an error-prone enzyme, for its transcription and replication.
Asad Sultan, Ashfaq Usman A, Sumrin Aleena, Ansar Muhammad, Ahmad Waqar, Ijaz Bushra, Kausar Humera, Sarwar Muhammad T, Gull Sana, Shahid Imran, Hassan Sajida   +10 more
doaj   +3 more sources

Cell culture replication of a genotype 1b hepatitis C virus isolate cloned from a patient who underwent liver transplantation. [PDF]

PLoS ONE, 2011
The introduction of the genotype 2a isolate JFH1 was a major breakthrough in the field of hepatitis C virus (HCV), allowing researchers to study the complete life cycle of the virus in cell culture.
George Koutsoudakis, Sofia Perez-del-Pulgar, Mairene Coto-Llerena, Patricia Gonzalez, Jakub Dragun, Laura Mensa, Gonzalo Crespo, Miguel Navasa, Xavier Forns   +8 more
doaj   +3 more sources

A Unique Genotype of Pseudohypoaldosteronism Type 1b in a Highly Consanguineous Population [PDF]

Journal of the Endocrine Society, 2021
Abstract Context Pseudohypoaldosteronism (PHA) is a condition in which serum aldosterone level is normal or elevated but its action is deficient. Objective This study describes the molecular genetics of PHA 1b in the highly ...
Ali S Alzahrani, Meshael Alswailem, Bassam Bin Abbas, Ebtesam Qasem, Afaf Alsagheir, Azza Al Shidhani, Aisha Al Sinani, Maryam Al Badi, Ali Al-Maqbali, Manal Al Shawi, Abdulhameed Albunyan, Abdulghani Bin Nafisah, Yufei Shi   +12 more
openaire   +2 more sources

Allele, genotype, and composite genotype effects of IL-1A +4845 and IL-1B +3954 polymorphisms for chronic periodontitis in an Indian population

Indian Journal of Dental Research, 2011
Introduction: The pro-inflammatory cytokine interleukin-1 (IL-1) is a key modulator of host responses to microbial infection and a major modulator of extracellular matrix catabolism and bone resorption, and polymorphisms in the IL-1 gene cluster have ...
R Gayathri, Abdul Vahab Saadi, K Mahalinga Bhat, Subraya G Bhat, Kapaettu Satyamoorthy   +4 more
doaj   +2 more sources

[beta-Interferon therapy of chronic hepatitis HCV+, 1b genotype].

Recenti progressi in medicina, 1998
Various papers reported that chronic viral hepatitis is the principal cause of chronic liver disease, as cirrhosis and hepatocarcinoma. Interferon is the only agent known to have a beneficial effect in chronic hepatitis. The response rate has been less than 10 percent in patients with genotype 1b, but in patients with genotype 2 or 3 it has been ...
VEZZOLI, MONIA, MAZZUCCHELLI, IOLANDA, GRITTI, DONATELLA, Girola, S, Fossati, G, Mazzone, A.   +5 more
openaire   +2 more sources

Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection. [PDF]

Hepatology, 2014
All-oral combinations of direct-acting antivirals may improve efficacy and safety outcomes for patients with hepatitis C virus (HCV) infection, particularly those who are poor candidates for current interferon/ribavirin-based regimens.
Kumada H, Suzuki Y, Ikeda K, Toyota J, Karino Y, Chayama K, Kawakami Y, Ido A, Yamamoto K, Takaguchi K, Izumi N, Koike K, Takehara T, Kawada N, Sata M, Miyagoshi H, Eley T, McPhee F, Damokosh A, Ishikawa H, Hughes E.   +20 more
europepmc   +4 more sources

Development of a Method for Screening and Genotyping of HCV 1a, 1b, 2, 3, 4, and 6 Genotypes [PDF]

ACS Omega, 2020
Abstract The World Health Organization and the World Health Assembly recommended eradicating hepatitis as a public threat by 2030. The accurate genotyping of hepatitis C virus (HCV) is crucial to achieving this goal because it is vital for the selection of anti-HCV therapy required for complete cure of HCV infection.
Shrikant Dashrath Warkad, Satish Balasaheb Nimse, Keum-Soo Song, Taisun Kim   +3 more
openaire   +3 more sources