Results 71 to 80 of about 263,661 (293)

The mutant spectrum for HCV genotype 1b.

, 2019
(A) The time-evolution of population of virions carrying different codons, color coded by the amino acids they encode. (B) The mutational pathway map with CGG, the wild-type codon for HCV genotype 1b at position 155 of the NS3 protein, as the founder ...
Narendra M. Dixit (135562), Rubesh Raja (5508425), Aditya Pareek (6533045), Kapil Newar (6533048)   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Effects of interferon treatment on the antiviral T-cell response in hepatitis C virus genotype 1b- and genotype 2c-infected patients

, 1997
The viral genotype may influence the response to interferon (IFN) treatment in chronic hepatitis C virus (HCV) infection. To characterize potential mechanisms responsible for this effect, we assessed whether IFN modulation of HCV-specific T-cell ...
Miyamura, T, Ravaggi, A, Cariani, E, Houghton, M, Missale, G, Rossini, A, Lamonaca, V, Bertoni, R, Matsuura, Y, Fiaccadori, F, FERRARI, Carlo   +10 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

SOCS3 and IRS-1 Gene Expression Differs Between Genotype 1 and Genotype 2 HCV-Infected HEPG2 Cells [PDF]

, 2009
BACKGROUND: The poor response to antiviral treatment of hepatitis C virus (HCV)-infected patients with genotype 1b has been associated with a higher prevalence of metabolic syndrome.
D. Spano, I. Andolfo, PERSICO, LICER ENRICO ANGELO, M. Svelto, M. Capasso, Persico, E, Russo, Roberta, RUSSO, RAFFAELE, Iolascon, A., Spano, Daniela, PERSICO, Marcello, Mura, Vincenzo La, CAPASSO, MARTA, R. Russo, Torella, R, Svelto, M, Spano, D, Andolfo, I, R. Torella, E. Persico, Iolascon, Achille, A. Iolascon, Andolfo, Immacolata, V. L. Mura, M. Persico, Persico, Eliana, Svelto, Monica, Capasso, Mario, C. Tiribelli, Torella, Roberto, La Mura, V, TIRIBELLI, CLAUDIO, V. La Mura   +32 more
core   +2 more sources

Genótipos do VHC. Histopatologia hepática e perfil imunológico em quatro grupos de doentes.

Acta Médica Portuguesa, 2000
Study on the prevalence of MCV genotypes, and correlation with liver pathology and immunological parameters.77 chronic hepatitis C patients (52 males, 25 females), mean age 44 +/- 14 years, belonging to four groups: (1) 23 (11 males) without other ...
A De Carvalho, A Martinho, J Leitão, M A Cipriano, H Coimbra, A Porto   +5 more
doaj   +1 more source

Inhibitory effects of caffeic acid phenethyl ester derivatives on replication of hepatitis C virus. [PDF]

PLoS ONE, 2013
Caffeic acid phenethyl ester (CAPE) has been reported as a multifunctional compound. In this report, we tested the effect of CAPE and its derivatives on hepatitis C virus (HCV) replication in order to develop an effective anti-HCV compound. CAPE and CAPE
Hui Shen, Atsuya Yamashita, Masamichi Nakakoshi, Hiromasa Yokoe, Masashi Sudo, Hirotake Kasai, Tomohisa Tanaka, Yuusuke Fujimoto, Masanori Ikeda, Nobuyuki Kato, Naoya Sakamoto, Hiroko Shindo, Shinya Maekawa, Nobuyuki Enomoto, Masayoshi Tsubuki, Kohji Moriishi   +15 more
doaj   +1 more source

Percentage inhibition of HCV-LP genotype 1b binding to Huh 7 cells using monoclonal antibodies.

, 2013
Percentage inhibition of HCV-LP genotype 1b binding to Huh 7 cells using monoclonal antibodies.
Rohini K. Shetty (103163), Giriprakash Chi (103173), Ranjitha Tatineni (103169), Saumitra Das (103180), Anjali Anoop Karande (103188), Soma Das (103160), Radhika Nagamangalam Shridharan (103166), Anuj Kumar (5797), Anirban Mukherjee (103177), Shaila Melkote Subbarao (103183)   +9 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A general method for nested RT-PCR amplification and sequencing the complete HCV genotype 1 open reading frame

Virology Journal, 2005
Background Hepatitis C virus (HCV) is a pathogenic hepatic flavivirus with a single stranded RNA genome. It has a high genetic variability and is classified into six major genotypes. Genotype 1a and 1b cause the majority of infections in the USA.
Tavis John E, Yao Ermei
doaj   +1 more source