Results 141 to 150 of about 706,514 (296)

CNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis

Advanced Science, EarlyView.
. ABSTRACT Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged
Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou   +8 more
wiley   +1 more source

Mixed HCV Infection of Genotype 1B and Other Genotypes Influences Non-response during Daclatasvir + Asunaprevir Combination Therapy.

Acta medica Okayama, 2018
Daclatasvir (DCV) + asunaprevir (ASV) combination therapy has become available for patients with hepatitis C virus (HCV) serogroup 1 infection. We studied the efficacy of this therapy by focusing on the factors associated with sustained virological responses (SVR) including resistance-associated variants (RAVs) and mixed infection of different HCV ...
Wada, Nozomu, Ikeda, Fusao, Mori, Chizuru, Takaguchi, Koichi, Fujioka, Shin-ichi, Kobashi, Haruhiko, Morimoto, Yoichi, Kariyama, Kazuya, Sakaguchi, Kosaku, Hashimoto, Noriaki, Moriya, Akio, Kawaguchi, Mitsuhiko, Miyatake, Hirokazu, Hagihara, Hiroaki, Kubota, Junichi, Takayama, Hiroki, Takeuchi, Yasuto, Yasunaka, Tetsuya, Takaki, Akinobu, Iwasaki, Yoshiaki, Okada, Hiroyuki   +20 more
openaire   +3 more sources

Neighbour-joining analysis of HCV genotype 1b core sequences.

, 2012
Comparison sequences were genotype 1b sequences randomly selected from the LANL HCV database. Study participants are denoted by diamonds. The first four letters of the name of the country of origin of LANL sequences is included in the ID.
Lilly Tracy (124023), Peter Higgs (124018), Rebecca Jenkinson (124030), Alyssa Barry (124052), Campbell Aitken (124014), David Rolls (124033), Philippa Pattison (124036), Margaret Hellard (124059), Garry Robins (124040), Jason Grebely (124046), Scott Bowden (124027), Rachel Sacks-Davis (124007), Galina Daraganova (124010)   +12 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Percentage of neutralization against genotype 1a and 1b culture viruses in 39 patients with chronic HCV, genotype 1, infection.

, 2013
Plasma samples from 39 patients, taken prior to treatment initiation with pegylated interferon-α and ribavirin, were tested against genotype 1a Core-NS2 recombinants (TN/JFH1, DH6/JFH1, and H77/JFH1) and genotype 1b Core-NS2 recombinants (DH1/JFH1, DH5 ...
Henrik Krarup (213503), Thomas H. R. Carlsen (162324), Peer Brehm Christensen (213500), Jens Bukh (162343), Kristian Schønning (410485), Nina Weis (213509), Jannie Pedersen (410483), Tanja B. Jensen (410484), Alex Lund Laursen (410486)   +8 more
core   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Hepatitis C virus genotype 1b and risk of hepatocellular carcinoma [PDF]

Hepatology, 1997
R Romeo, M G Rumi, N i Del, M Colombo
openaire   +2 more sources

The Supply Side of Innovation: H-1B Visa Reforms and US Ethnic Invention [PDF]

This study evaluates the impact of high-skilled immigrants on US technology formation. We use reduced-form specifications that exploit large changes in the H-1B visa program.
William Kerr, William Lincoln
core  

Model fit for patients with genotype 1b HCV.

, 2014
(A): Histogram of the log10 objective function values (φ; see Equation 5) for all patients with genotype 1b. Dashed lines and numbers show quantile information for the fits.
Doug J. Bartels (171434), Inge Dierynck (171456), Joan Spanks (171460), Anne Ghys (171476), Ann M. Tigges (610823), Gaston Picchio (171523), Tara L. Kieffer (171419), Andrew Davis (47896), Eileen Z. Zhang (171445), James C. Sullivan (13811), Eric L. Haseltine (610822), Sandra De Meyer (171427)   +11 more
core   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

Advanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang   +12 more
wiley   +1 more source