Results 261 to 270 of about 380,405 (282)

Hepatitis C genotype 1b and 4 cured after telaprevir-based therapy

, 2015
Pérez-Parente, Diego, Suárez-Ordóñez, Sandra, Suárez-Santamaría, Marta, Morano-Amado, Luis E.   +3 more
openaire   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

Hepatitis C Virus Genotypes 1a and 1b Mixed Infections

Vox Sanguinis, 1997
AbstractIn response to Poljak and Seme's letter, we would like to point out that the manuscript published in another journal [1], although based on the same study population, was only meant to discuss the results of Pawlotsky et al. [2], who claimed that hepatitis C virus (HCV) genotype 3a was the predominant type among injecting drug users (IDUs) in ...
V. Soriano, R. Bravo, J. García‐Samaniego   +2 more
openaire   +1 more source

Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview

American Journal of Obstetrics and Gynecology, 2007
Fetal alcohol syndrome (FAS), 1 of the most common developmental disabilities in the United States, occurs at a rate of 0.5-2.0:1000 live births. Animal model, family, and twin studies suggest a genetic component to FAS susceptibility. Alcohol dehydrogenases (ADHs) catalyze the rate-limiting step in alcohol metabolism.
Ridgely Fisk, Green, Joan Marilyn, Stoler   +1 more
openaire   +2 more sources

Hepatitis C Virus Genotype 1b Vaccine can Benefit Egyptians, where Genotype 4a prevails (105.39)

The Journal of Immunology, 2012
Abstract Hepatitis C Virus (HCV) infection is a global health burden specially in Egypt, where HCV genotype 4a predominates. Control of HCV infection will remain a challenge until the development of an effective vaccine that protects against different genotypes. There are several HCV genotype 1 vaccines in the pipelines.
Sayed Abdelwahab, Iman Fathy, Zainab Zakaria, Imam Waked, Mohamed Mahmoud, Stefania Capone, Alfredo Nicosia, Antonella Folgori, Ahmed Refaat, Ahmed Osman, G Thomas Strickland, Riccardo Cortese   +11 more
openaire   +1 more source

A genotype 2b NS5B polymerase with novel substitutions supports replication of a chimeric HCV 1b:2b replicon containing a genotype 1b NS3-5A background

Antiviral Research, 2006
HCV diversity suggests that evaluation of HCV inhibitors for broad genotypic efficacy is warranted. The replicon system enables cell-culture compound efficacy evaluation against an active replication complex, and a functional replicon dependent upon a genotype 2b polymerase would augment existing cell-culture efficacy studies that are presently limited
Donald J, Graham, Mark, Stahlhut, Osvaldo, Flores, David B, Olsen, Daria J, Hazuda, Robert L, Lafemina, Steven W, Ludmerer   +6 more
openaire   +2 more sources

Hepatitis C flare due to superinfection by genotype 4 in an HCV genotype 1b chronic carrier

European Journal of Gastroenterology & Hepatology, 2002
We report here on a patient affected by chronic hepatitis C who developed acute hepatitis C virus (HCV) superinfection with replacement of genotype 1b by genotype 4. The history revealed no risk factors for a new exposure to HCV, with the exception of colonoscopy with mucosal biopsy performed about 3 months before. This report underlines the absence of
ACCAPEZZATO, DANIELE, Francesca Fravolini, Marco Antonio Casciaro, PAROLI, Marino   +3 more
openaire   +2 more sources

Transient replication of a hepatitis C virus genotype 1b replicon chimera encoding NS5A-5B from genotype 3a

Journal of Virological Methods, 2014
Although hepatitis C virus (HCV) is a pathogen of global significance, experimental therapies in current clinical development include highly efficacious all-oral combinations of HCV direct-acting antivirals (DAAs). If approved for use, these new treatment regimens will impact dramatically upon our capacity to eradicate HCV in the majority of virus ...
Helen, Kylefjord, Axel, Danielsson, Susanne, Sedig, Oscar, Belda, Daniel, Wiktelius, Lotta, Vrang, Paul, Targett-Adams   +6 more
openaire   +2 more sources

Replacement of Hepatitis C Virus Genotype 1b by Genotype 2 Over a 10-year Period in Venezuela

Journal of Clinical Gastroenterology, 2007
Changes in hepatitis C virus (HCV) genotype distribution with time have been reported in several countries.To explore eventual changes in HCV genotype distribution in Venezuela over a 10 years period.HCV genotype was determined by direct sequencing of the 5' noncoding region, in 236 isolates circulating in patients treated during years 2005 to 2006 ...
Flor H, Pujol, Carmen L, Loureiro
openaire   +2 more sources

Detergent-induced activation of the hepatitis C virus genotype 1b RNA polymerase

Gene, 2012
Recently, we found that sphingomyelin bound and activated hepatitis C virus (HCV) 1b RNA polymerase (RdRp), thereby recruiting the HCV replication complex into lipid raft structures. Detergents are commonly used for resolving lipids and purifying proteins, including HCV RdRp.
Leiyun, Weng, Michinori, Kohara, Takaji, Wakita, Kunitada, Shimotohno, Tetsuya, Toyoda   +4 more
openaire   +2 more sources

Emergence of Hepatitis C Virus Genotype Recombinant Forms 2k/1b in Georgia

Clinical Laboratory, 2016
Hepatitis C virus (HCV) evolution is thought to proceed by mutations within the six major genotypes. Studies of HCV recombinant genotypes in different parts of the world have recently been initiated. Only a few cases of recombination have been identified worldwide, predominantly in Eastern Europe and Asia.
Mamuka, Zakalashvili, Michael, Weizenegger, Jan, Bartel, Monika, Markowski, Jaba, Zarqua, Salome, Kavsadze, Ketevan, Kvatadze, George, Basheleishvili, Tamar, Phirtskhalaishvili, Tamar, Dzagania, Lela, Zangurashvili, Nino, Kankia, Nino, Jashiashvili, Maka, Lomidze, Tengiz, Telia, Vakhtang, Kerashvili, Maia, Zhamutashvili, Nikoloz, Abramishvili, Irakli, Rtskhiladze, David, Metreveli   +19 more
openaire   +2 more sources