Results 91 to 100 of about 1,921,022 (384)

Pooled DNA genotyping on Affymetrix SNP genotyping arrays [PDF]

BMC Genomics, 2006
Abstract Background Genotyping technology has advanced such that genome-wide association studies of complex diseases based upon dense marker maps are now technically feasible. However, the cost of such projects remains high.
Valentina Moskvina, Lyudmila Georgieva, Ivan Nikolov, Michael John Owen, Michael Conlon O'Donovan, George Kirov   +5 more
openaire   +4 more sources

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.

American Journal of Human Genetics, 2006
A functional serotonin transporter promoter polymorphism, HTTLPR, alters the risk of disease as well as brain morphometry and function. Here, we show that HTTLPR is functionally triallelic.
Xian-zhang Hu, Robert Lipsky, Guanshan Zhu, Longina A. Akhtar, J. Taubman, B. Greenberg, Ke Xu, P. Arnold, M. Richter, J. Kennedy, D. Murphy, D. Goldman   +11 more
semanticscholar   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Increased Sensitivity of Plasmodium falciparum to Artesunate/Amodiaquine Despite 14 Years as First-Line Malaria Treatment, Zanzibar

Emerging Infectious Diseases, 2020
Artemisinin-based combination therapies (ACTs) are first-line treatments for uncomplicated Plasmodium falciparum malaria. ACT resistance is spreading in Asia but not yet in Africa.
Mwinyi Msellem, Ulrika Morris, Aungpaing Soe, Faiza B. Abbas, Abdul-Wahid Ali, Rory Barnes, Paolo Frumento, Abdullah S. Ali, Andreas Mårtensson, Anders Björkman   +9 more
doaj   +1 more source

Comparison of multiple typing methods for Aspergillus fumigatus [PDF]

, 2009
As part of studies on the spread of infections, risk factors and prevention, several typing methods were developed to investigate the epidemiology of Aspergillus fumigatus. In the present study, 52 clinical isolates of A.
Coenye, Tom, Jacobsen, MD, Nelis, Hans, Symoens, F, Vanhee, Lies   +4 more
core   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Hepatitis B virus genotypes and variants.

Cold Spring Harbor Perspectives in Medicine, 2015
At least 10 hepatitis B virus (HBV) genotypes (A to J) with distinct geographic distributions and several HBV mutants, including precore/core promoter mutations and pre-S/S deletion mutations, have been recognized to be not only predictive of liver ...
Chih‐Lin Lin, J. Kao
semanticscholar   +1 more source

Predominance of Rotavirus P[4]G2 in a Vaccinated Population, Brazil

Emerging Infectious Diseases, 2007
We identified 21 rotaviruses in 129 patients with diarrhea in a Brazilian city with high rotavirus vaccine coverage. All rotaviruses were genotype P[4]G2 with 1 mixed infection with P[NT]G9.
Ricardo Q. Gurgel, Luis E. Cuevas, Sarah C.F. Vieira, Vanessa C.F. Barros, Paula B. Fontes, Eduardo F. Salustino, Osamu Nakagomi, Toyoko Nakagomi, Winifred Dove, Nigel Cunliffe, Charles A. Hart   +10 more
doaj   +1 more source

Molecular characterization of Mycobacterium bovis infection in cattle and buffalo in Amazon Region, Brazil

Veterinary Medicine and Science, 2020
The aim of this study was to characterize Mycobacterium bovis from cattle and buffalo tissue samples, from two Brazilian states, and to analyse their genetic diversity by spoligotyping.
Paulo A. M. Carneiro, Taynara. N. Pasquatti, Haruo Takatani, Martin J. Zumárraga, Maria. J. Marfil, Christian Barnard, Scott D. Fitzgerald, Robert B. Abramovitch, Flábio R. Araujo, John B. Kaneene   +9 more
doaj   +1 more source