Results 91 to 100 of about 1,163,135 (344)

Upfront Genotyping of DPYD*2A to Individualize Fluoropyrimidine Therapy: A Safety and Cost Analysis.

Journal of Clinical Oncology, 2016
PURPOSE Fluoropyrimidines are frequently prescribed anticancer drugs. A polymorphism in the fluoropyrimidine metabolizing enzyme dihydropyrimidine dehydrogenase (DPD; ie, DPYD*2A) is strongly associated with fluoropyrimidine-induced severe and life ...
M. Deenen, D. Meulendijks, A. Cats, M. Sechterberger, J. Severens, H. Boot, P. Smits, H. Rosing, C. Mandigers, M. Soesan, J. Beijnen, J. Schellens   +11 more
semanticscholar   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

Resolving Individuals Contributing Trace Amounts of DNA to Highly Complex Mixtures Using High-Density SNP Genotyping Microarrays

PLoS Genetics, 2008
We use high-density single nucleotide polymorphism (SNP) genotyping microarrays to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture.
Nils Homer, S. Szelinger, Margot Redman, D. Duggan, Waibhav Tembe, Jill Muehling, J. Pearson, D. Stephan, S. Nelson, D. Craig   +9 more
semanticscholar   +1 more source

Knockout of the mitoribosome rescue factors Ict1 or Mtrfr is viable in zebrafish but not mice: compensatory mechanisms underlying each factor's loss

FEBS Open Bio, EarlyView.
Mitochondria contain two mitoribosome rescue factors, ICT1 and MTRFR (C12orf65). ICT1 also functions as a mitoribosomal protein in mice and humans, and its loss is lethal. Although Mtrfr knockout mice could not be generated, knockout zebrafish lines for ict1 and mtrfr were established.
Nobukazu Nameki, Chika Tomisawa, Soichiro Hoshino, Hidehiko Shimizu, Masashi Abe, Sho Arai, Kanako Kuwasako, Naoki Asakawa, Yusuke Inoue, Takuro Horii, Izuho Hatada, Masakatsu Watanabe   +11 more
wiley   +1 more source

Departure from Hardy Weinberg Equilibrium and Genotyping Error

Frontiers in Genetics, 2017
Objective: Departure from Hardy Weinberg Equilibrium (HWE) may occur due to a variety of causes, including purifying selection, inbreeding, population substructure, copy number variation or genotyping error.
Bowang Chen, J. Cole, C. Grond-Ginsbach
semanticscholar   +1 more source

Genetic diversity and population structure of the Taigan dog breed

FEBS Open Bio, EarlyView.
The Taigan is a rare sighthound from the mountains of Kyrgyzstan. We used DNA markers to study its genetic diversity and compare it with other sighthound breeds. Our findings show that the Taigan shares close genetic ties with the Kazakh Tazy, suggesting a common ancestry shaped by nomadic traditions and regional adaptation.
Kira Bespalova, Anastassiya Perfilyeva, Мamura Begmanova, Assel Zhaxylykova, Arailym Yerzhan, Kanagat Yergali, Almazbek Akunov, Marat Munarbek uulu, Anna Khamchukova, Almira Amirgaliyeva, Yelena Kuzovleva   +10 more
wiley   +1 more source

Structural and Biochemical Properties of Duckweed Surface Cuticle

Frontiers in Chemistry, 2018
The plant cuticle, which consists of cutin and waxes, forms a hydrophobic coating covering the aerial surfaces of all plants. It acts as an interface between plants and their surrounding environment whilst also protecting them against biotic and abiotic ...
Nikolai Borisjuk, Anton A. Peterson, Jiyang Lv, Guorun Qu, Qian Luo, Lei Shi, Guimin Chen, Olena Kishchenko, Yuzhen Zhou, Jianxin Shi   +9 more
doaj   +1 more source

High-resolution genotyping by amplicon melting analysis using LCGreen.

Clinical Chemistry, 2003
BACKGROUND High-resolution amplicon melting analysis was recently introduced as a closed-tube method for genotyping and mutation scanning (Gundry et al. Clin Chem 2003;49:396-406).
C. Wittwer, G. H. Reed, C. N. Gundry, J. Vandersteen, R. Pryor   +4 more
semanticscholar   +1 more source

Analysis of the regulation of undecaprenyl diphosphate dephosphorylation in Escherichia coli

FEBS Open Bio, EarlyView.
BacA, PgpB, and YbjG phosphatases are involved in undecaprenyl phosphate (C55P) synthesis in Escherichia coli. We analyzed the lipid contents and the gene expression in the gene‐disruption strains. Undecaprenyl diphosphate (C55PP) level increased in the bacA, ybjG double‐disruption strain, but C55P levels were similar in all strains.
Tomotaka Jitsukawa, Yasushi Shigeri, Shingo Fujisaki   +2 more
wiley   +1 more source

Strategies for processing and quality control of Illumina genotyping arrays

Briefings Bioinform., 2018
Illumina genotyping arrays have powered thousands of large-scale genome-wide association studies over the past decade. Yet, because of the tremendous volume and complicated genetic assumptions of Illumina genotyping data, processing and quality control ...
Shilin Zhao, Jing Wang, D. Samuels, Quanghu Sheng, Shyr Yu, Yan Guo   +5 more
semanticscholar   +1 more source