PLoS Genetics, 2008 We use high-density single nucleotide polymorphism (SNP) genotyping microarrays to demonstrate the ability to accurately and robustly determine whether individuals are in a complex genomic DNA mixture.
Nils Homer +9 more
semanticscholar +1 more source
Discovery and genotyping of structural variation from long-read haploid genome sequence data [PDF]
, 2016 In an effort to more fully understand the full spectrum of human genetic variation, we generated deep single-molecule, real-time (SMRT) sequencing data from two haploid human genomes.
Boitano, Matthew +15 more
core +2 more sources
Estimation of pedigree errors in the UK dairy population using microsatellite markers and the impact on selection [PDF]
, 2002 The proportion of cows in the UK dairy herd whose sires were misidentified was estimated using DNA markers. Genetic marker genotypes were determined on 568 cows (from 168 milk samples and 400 hair samples) and 96 putative sires (from semen samples).
Smith, D. +3 more
core +1 more source
Departure from Hardy Weinberg Equilibrium and Genotyping Error
Frontiers in Genetics, 2017 Objective: Departure from Hardy Weinberg Equilibrium (HWE) may occur due to a variety of causes, including purifying selection, inbreeding, population substructure, copy number variation or genotyping error.
Bowang Chen, J. Cole, C. Grond-Ginsbach
semanticscholar +1 more source
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque [PDF]
, 2011 Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events.
A Dehghan +128 more
core +2 more sources
Scientific Reports, 2015 Restriction-enzyme (RE)-based next-generation sequencing methods have revolutionized marker-assisted genetic studies; however, the use of REs has limited their widespread adoption, especially in field samples with low-quality DNA and/or small quantities ...
Y. Suyama, Y. Matsuki
semanticscholar +1 more source
Identification of the Kna/Knb polymorphism and a method for Knops genotyping [PDF]
, 2004 BACKGROUND: DNA mutations resulting in the McCoy and Swain-Langley polymorphisms have been identified on complement receptor 1 (CR1)—a ligand for rosetting of Plasmodium falciparum-infected RBCs.
Daniels +17 more
core +1 more source
An Inversion Disrupting FAM134B Is Associated with Sensory Neuropathy in the Border Collie Dog Breed [PDF]
, 2016 Sensory neuropathy in the Border Collie is a severe neurological disorder caused by the degeneration of sensory and, to a lesser extent, motor nerve cells with clinical signs starting between 2 and 7 months of age.
Beltran, E +9 more
core +4 more sources
An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid
Nature Communications, 2016 The population of Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, exhibits limited DNA sequence variation, which complicates efforts to rationally discriminate individual isolates.
V. Wong +83 more
semanticscholar +1 more source
Genotype-environment interaction of genotypes of cocoa in Mexico
Scientific ReportsAbstract Cacao (Theobroma cacao L.) production is significantly influenced by genotype-environment interactions, which affect key agronomic traits such as yield, fruit quality, and disease resistance. Despite advances in cacao breeding, one of the main challenges remains the identification of stable, high-performing clones that can adapt to ...
Carlos Hugo Avendaño-Arrazate +5 more
openaire +3 more sources