Results 111 to 120 of about 806 (159)

Biotransformation of Gentiopicroside by Asexual Mycelia of Cordyceps sinensis

Bioorganic and Medicinal Chemistry Letters, 2007
The biotransformation of gentiopicroside by asexual mycelia of Cordyceps sinensis yielded two products, one of which was proved to be a new pyridine monoterpene alkaloid. The possible mechanisms were discussed.
Min Xu, Ying-Jun Zhang, Chong-Ren Yang
exaly   +3 more sources

Bioactivity of Gentiopicroside From the Aerial Parts of Centaurium erythraea

Fìtoterapìâ, 2003
Gentiopicroside (1), a secoiridoid glycoside isolated from the methanol extract of the aerial parts of Centaurium erythraea, has been assessed for antibacterial and free radical scavenging activities. General toxicity of 1 has also been determined by brine shrimp lethality bioassay.
Yashodharan Kumarasamy, S D Sarker, S D Sarker   +2 more
exaly   +3 more sources

Synthesis, and anti-inflammatory activities of gentiopicroside derivatives

Chinese Journal of Natural Medicines, 2022
A series of 26 novel derivatives have been synthesized through structural modification of gentiopicroside, a lead COX-2 inhibitor. And their in vivo and in vitro anti-inflammatory activities have been investigated. The in vitro anti-inflammatory activities were evaluated against NO, PGE2, and IL-6 production in the mouse macrophage cell line RAW264.7 ...
Qi-Li, Zhang, Peng-Fei, Xia, Xue-Jing, Peng, Xiao-Yu, Wu, Hua, Jin, Jian, Zhang, Lei, Zhao   +6 more
openaire   +2 more sources

Regulatory mechanisms of Gentiopicroside on human diseases: a brief review

Naunyn-Schmiedeberg's Archives of Pharmacology, 2023
Gentiopicroside (GPS), a single compound isolated from Gentiana lutea L. and the crucial representative of secoiridoid constituent, has been permitted for centuries in traditional Chinese medicine. GPS and its metabolites have been increasingly used in the search for clinical management with therapeutic properties and fewer side effects.
Bin Liu, Feng Pang, Hongsheng Bi, Dadong Guo   +3 more
openaire   +2 more sources

Structure of gentiopicroside

Tetrahedron Letters, 1960
Abstract A new formula for the gentiopicroside (I), the principal bitter glucoside of common gentians, is proposed.
L. Canonica, F. Pelizzoni, P. Manitto, G. Jommi   +3 more
openaire   +1 more source

Gentiogenal, a Conversion Product of Gentiopicrin (Gentiopicroside)*

Planta Medica, 1983
The structure of gentiogenal, (+/-)5-formyl-6-methyl-3,4-dihydro-1H,6H-pyrano-[3,4-c-]-pyran-1-one, a conversion product of the aglucone of gentiopicrin (gentiopicroside), isolated from BLACKSTONIA PERFOLIATA (Gentianaceae), was elucidated by (1)H- and (13)C NMR spectroscopic, mass spectrometric and X-ray diffraction methods.
W G, van der Sluis, J M, van der Nat, A L, Spek, Y, Ikeshiro, R P, Labadie   +4 more
openaire   +2 more sources

A new iridoid precursor of gentiopicroside

Phytochemistry, 1971
Abstract Two new iridoids have been isolated from some Gentiana species. One of them, named gentioside, acts as an effective precursor of gentiopicroside (II). Its structure (V) comprising features of gentiopicroside and loganin (III) is given. The structure of the second iridoid is probably of the aucubin type.
S. Popov, N. Marekov
openaire   +1 more source

Biomimetic Transformation of Gentiopicroside to Erythrocentaurin

Chinese Chemical Letters, 2009
Abstract Biomimetic transformation of gentiopicroside was carried out by β-glucosidase at pH 7.0 for 3 days at 37 °C. Two products, erythrocentaurin and 5,6-dihydro-5-formyl-6-methyl-1H,3H-pyrano[3,4-c]pyran-1-one were isolated and identified by 1H NMR, 13C NMR, UV, IR, MS and elemental analyse. The possible mechanisms were discussed.
Cui Ling Wang, Jian Li Liu, Zhu Lan Liu, Xin Sheng Li, Xiao Yong Cao   +4 more
exaly   +2 more sources

Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats

Life Sciences, 2021
This study aimed to examine whether gentiopicroside (GPS) could exert hepatoprotective effects on leflunomide (LEF)- and/or methotrexate (MTX)-treated arthritic rats through anti-inflammatory and antioxidant pathways.We observed the external symptoms of joints, analysed serum indicators, measured haematological parameters and mRNA levels, and performed
Zhijie, Wan, He, Li, Xiaohan, Wu, Haiyun, Zhao, Ran, Wang, Mengmeng, Li, Jing, Liu, Qingfeng, Liu, Rui, Wang, Xiaotian, Li   +9 more
openaire   +2 more sources

Effect of D-cellobiose on oral bioavailability of gentiopicroside

China Journal of Chinese Materia Medica, 2016
In this study, the effect of D-cellobiose on oral bioavailability of gentiopicroside (GPS) was investigate. The influence of D-cellobiose on GPS was achieved by calculating the residual GPS after being degraded with β-glucosidase or intestinal flora, and the data demonstrated D-cellobiose could inhibit the degradation of GPS in intestines; in ...
Yun-Hao, Dai, Man, Wang, Ya-Nan, Zhu, Lu-Lu, Wang, Jian-Ming, Ju, Zhen-Hai, Zhang   +5 more
openaire   +2 more sources