Results 121 to 130 of about 806 (159)

Metabolomic Evidence for the Therapeutic Effect of Gentiopicroside in a Corticosterone-Induced Model of Depression

Biomedicine and Pharmacotherapy, 2019
Depression is a disease that seriously threatens the quality of human life. To explore the effect of gentiopicroside on depression, this study investigated the therapeutic effect of gentiopicroside on corticosterone-induced depressionin vivo and in vitro by using metabolomic methods.A total of 36 rats were randomly assigned to three groups: a normal ...
Tao Yao, Zhichao Liu, Qin Cui
exaly   +3 more sources

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(±)-Gentiovarisin A and gentiovarisin B, unusual secoiridoid dimer skeletons from gentiopicroside

Fitoterapia, 2022
Gentiana scabra, a famous traditional Chinese medicine (TCM), has been documented in Chinese Pharmacopoeia for the treatment of hepatitis. Its index component gentiopicroside could not be detected in the decoction, which suggested that the quality control of the TCM with this ingredient needs attention.
Ping-Xing, Qi, Shuang-Shuang, Liu, Peng, Zhang, Yan-Qing, Xie, Zhu-Ya, Yang, Afsar, Khan, Lu, Liu   +6 more
openaire   +2 more sources

Research Progress of Natural Product Gentiopicroside - a Secoiridoid Compound

Mini-Reviews in Medicinal Chemistry, 2016
Gentiopicroside is a secoiridoid compound isolated from Gentiana lutea which is called Qin Jiao in Chinese. It is one of the most common herbal medicines used in China. In this article, we review the pharmacological and biological activity (antiviral, anti-inflammatory, analgesia, antihepatotoxic and choleretic), as well as biotransformation of the ...
Wu, Shaoping, Ning, Yaoyao, Zhao, Yingyong, Sun, Wenji, Thorimbert, Serge, Dechoux, Luc, Sollogoub, Matthieu, Zhang, Yongmin   +7 more
openaire   +2 more sources

Gentiopicroside Is Located in the Vacuoles of Root Protoplasts of Gentiana lutea

Journal of Plant Physiology, 1986
Summary Gentiopicroside, the main secoiridoid glucoside of Gentiana lutes roots, was found to be evenly distributed throughout the cross-section of the roots at a concentration of 14.7 mg/g fwt. The subcellular compartmentation of gentiopicroside was studied by isolating protoplasts and vacuoles and comparing their content.
Felix Keller
exaly   +2 more sources

Pharmacokinetics and bioavailability of gentiopicroside from decoctions of Gentianae and Longdan Xiegan Tang after oral administration in rats—Comparison with gentiopicroside alone

Journal of Pharmaceutical and Biomedical Analysis, 2007
The pharmacokinetics and bioavailability of gentiopicroside (GPS), an active component of the Gentian plant species, from orally administered decoctions of Gentianae (DG), or in combination with other plants in the prescription of Longdan Xiegan Tang (LXT), was compared in rats with oral administration of GPS alone, using doses adjusted to deliver ...
Chang-hong, Wang, Xue-mei, Cheng, S W Annie, Bligh, Kenneth N, White, Christopher J, Branford-White, Zheng-tao, Wang   +5 more
openaire   +2 more sources

Suppression of Chemically and Immunologically Induced Hepatic Injuries by Gentiopicroside in Mice

Planta Medica, 1994
Gentiopicroside (GPS), a main bitter secoiridoid constituent of roots of Gentiana macrophylla Pall., was tested for therapeutic effects on the two hepatic injury models, the CCl4-induced and lipopolysaccharide (LPS)/bacillus Calmette-Guerin (BCG)-induced hepatitides. An increase in serum level of hepatic aminotransferases (GOT: EC 2.6.1.1.
Y, Kondo, F, Takano, H, Hojo
openaire   +2 more sources

Studies on Iridoid-Related Compounds III: Gentiopicral, the Aglucone of Gentiopicroside

Planta Medica, 1983
Enzymatic hydrolysis of gentiopicroside ( 1) provided the new aglucone, gentiopicral ( 2), the structure of which was firmly elucidated by means of spectroscopic methods.
M Yamaki, K Ishiguro
exaly   +3 more sources

Gentiopicroside: An Updated Review of Its Pharmacological Activities and Mechanisms

Chemistry & Biodiversity
ABSTRACT Gentiopicroside (GPS) is a bioactive iridoid glycoside isolated from Gentianaceae plants. In recent years, GPS has received increasing attention due to its multiple pharmacological activities.
Yin Ding, Xiaoling Gou, Xinyue Wu, Yiwen Tao, Yaqian Wang, Yue Wang, Jingye Liu, Xianhua Zhou, Tingting Kuang, Gang Fan   +9 more
openaire   +2 more sources

Separation and determination of gentiopicroside and swertiamarin in Tibetan medicines by micellar electrokinetic electrophoresis

Biomedical Chromatography, 2003
AbstractMicellar electrokinetic electrophoresis was employed to determine two active components, gentiopicroside (GE) and swertiamarin (SW) in one Tibetan preparation medicine named shiweilongdankeli, two Tibetan herbal medicines named Gentiana rhodantha and Gentiana kitag and three other Chinese Gentiana medicines named Gentiana scabra, Gentiana ...
Shengguo, Zhao, Qing, Liu, Xingguo, Chen, Zhide, Hu   +3 more
openaire   +2 more sources

Pharmacokinetics and tissue distribution of Gentiopicroside following oral and intravenous administration in mice

European Journal of Drug Metabolism and Pharmacokinetics, 2004
The pharmacokinetics and tissue distribution of Gentiopicroside (GPS), one of the major active components of the Gentiana species of medicinal plants, was studied following oral and intravenous administration in mice. The distribution of GPS in mice after oral and intravenous doses could be fitted to a two-compartments open model.
Chang-Hong, Wang, Zheng-Tao, Wang, S W Annie, Bligh, Kenneth N, White, Christopher J Branford, White   +4 more
openaire   +2 more sources