Results 21 to 30 of about 1,535,618 (326)

Geographic atrophy of the macula

Delta Journal of Ophthalmology, 2015
Geographic atrophy of the macula is a late form of dry AMD. Changes found on optical coherence tomography imaging (OCT) include Retinal Pigment Epithelium (RPE) atrophic changes and window defects, with a pronounced photorecetor layer damage.
Alaa M Fadel
doaj   +1 more source

Comparing Accuracies of Length-Type Geographic Atrophy Growth Rate Metrics Using Atrophy-Front Growth Modeling

Ophthalmology Science, 2022
Purpose: To compare the accuracies of the previously proposed square-root-transformed and perimeter-adjusted metrics for estimating length-type geographic atrophy (GA) growth rates. Design: Cross-sectional and simulation-based study. Participants: Thirty-
Eric M. Moult, PhD, Yingying Shi, MD, Liang Wang, BS, Siyu Chen, PhD, Nadia K. Waheed, MD, MPH, Giovanni Gregori, PhD, Philip J. Rosenfeld, MD, PhD, James G. Fujimoto, PhD   +7 more
doaj   +1 more source

Epidemiology of geographic atrophy and its precursor features of intermediate age‐related macular degeneration

Acta ophthalmologica, 2023
Globally age‐related macular degeneration (AMD) is a leading cause of blindness with a significant impact on quality of life. Geographic atrophy (GA) is the atrophic late form of AMD and its prevalence increases markedly with age with around 1 in 5 ...
S. Vujosevic, C. Alovisi, U. Chakravarthy   +2 more
semanticscholar   +1 more source

Is There a Relationship Between Use of Anti-Vascular Endothelial Growth Factor Agents and Atrophic Changes in Age-Related Macular Degeneration Patients?

Türk Oftalmoloji Dergisi, 2018
Choroidal neovascularization due to age-related macular degeneration (AMD) is currently treated successfully with anti-vascular endothelial growth factor (VEGF) intravitreal agents.
Süleyman Kaynak, Mahmut Kaya, Derya Kaya   +2 more
doaj   +1 more source

Complement Inhibitors for Advanced Dry Age-Related Macular Degeneration (Geographic Atrophy): Some Light at the End of the Tunnel?

Journal of Clinical Medicine, 2023
Geographic atrophy (GA) affects around 5 million individuals worldwide. Genome-wide, histopathologic, in vitro and animal studies have implicated the activation of the complement system and chronic local inflammation in the pathogenesis of GA.
Miguel Cruz-Pimentel, Lihteh Wu
semanticscholar   +1 more source

Serum lipids in adults with late age-related macular degeneration: a case-control study

Lipids in Health and Disease, 2019
Background Lipids are implicated in the pathogenesis of age-related macular degeneration (AMD). The relationship between systemic lipids and AMD has not been well characterized.
Richard D. Semba, Ruin Moaddel, Mary Frances Cotch, Fridbert Jonasson, Gudny Eiriksdottir, Tamara B. Harris, Lenore J. Launer, Kai Sun, Ronald Klein, Debra A. Schaumberg, Pálmi Jónsson, Vilmundur Gudnason, Luigi Ferrucci   +12 more
doaj   +1 more source

Complement C3 variant and the risk of age-related macular degeneration [PDF]

, 2007
Background: Age-related macular degeneration is the most common cause of blindness in Western populations. Susceptibility is influenced by age and by genetic and environmental factors.
Armbrecht, AM, Bird, AC, Clayton, DG, Deary, IJ, Dhillon, B, Genetic Factors AMD Study G, Hayward, C, Khan, JC, Matharu, BK, Moore, AT, Morgan, J, Redmond, E, Sepp, T, Shahid, H, Thurlby, DA, Wright, AF, Yates, JRW   +16 more
core   +1 more source

Test–retest variability of microperimetry in geographic atrophy

International Journal of Retina and Vitreous, 2020
Purpose Microperimetry (MP) allows for measurement of retinal sensitivity at precise locations and is now commonly employed as a clinical trial endpoint.
A. Yasin Alibhai, Nihaal Mehta, Sheila Hickson-Curran, Carlos Moreira-Neto, Emily S. Levine, Elias Reichel, Jay S. Duker, Nadia K. Waheed   +7 more
doaj   +1 more source

Prioritising the Burden of Geographic Atrophy and Treatment Expectations: A Modified Nominal Group Technique Study with International Patient-Led Organisations. [PDF]

Clin Ophthalmol
Paudel N, Moran EM, Stafford S, McVicker K, Stratieva P, Daly A.   +5 more
europepmc   +3 more sources

Clinical validation for automated geographic atrophy monitoring on OCT under complement inhibitory treatment

Scientific Reports, 2023
Geographic atrophy (GA) represents a late stage of age-related macular degeneration, which leads to irreversible vision loss. With the first successful therapeutic approach, namely complement inhibition, huge numbers of patients will have to be monitored
Julia Mai, D. Lachinov, Sophie Riedl, G. Reiter, Wolf-Dieter Vogl, Hrvoje Bogunović, U. Schmidt-Erfurth   +6 more
semanticscholar   +1 more source