Results 61 to 70 of about 6,719,781 (362)
The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Bias Reduction in Robust Mean–Geometric Mean Linking via SIMEX
AlgorithmsRobust mean–geometric mean (MGM) linking is a method for comparing the performance of two groups on a test involving dichotomous items and is particularly suited to settings with fixed and sparse differential item functioning (DIF).
Alexander Robitzsch
doaj +1 more source
Land, 2023 Land use planning is a science that specifies the optimized use of land based on ecological and socioeconomic characteristics. In many parts of Iran, the selection and management of land use (development, especially) is performed regardless of land ...
Masoud Masoudi +3 more
doaj +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
A probabilistic method for gradient estimates of some geometric flows
, 2015 In general, gradient estimates are very important and necessary for deriving convergence results in different geometric flows, and most of them are obtained by analytic methods.
Chen, Xin, Cheng, Li-Juan, Mao, Jing
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Optimal power mean bounds for the second Yang mean
Journal of Inequalities and Applications, 2016 In this paper, we present the best possible parameters p and q such that the double inequality M p ( a , b ) < V ( a , b ) < M q ( a , b ) $$ M_{p}(a,b)< V(a,b)< M_{q}(a,b) $$ holds for all a , b > 0 $a, b>0$ with a ≠ b $a\neq b$ , where M r ( a , b ) = [
Jun-Feng Li, Zhen-Hang Yang, Yu-Ming Chu
doaj +1 more source
GMO: Geometric Mean Optimizer for Solving Engineering Problems [PDF]
, 2022 Farshad Rezaei +3 more
openalex +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source