Results 71 to 80 of about 42,080 (309)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Improvements in 3-D digital mapping for geomorphological and Quaternary geological cartography [PDF]

Geographica Helvetica, 2015
In recent decades, GIS tools have been directly applied to photo-interpretative geomorphological and geological mapping. Although these tools are powerful and effective tools in the creation of digital maps, it is often very difficult to obtain a correct
C. Ambrosi, C. Scapozza
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Earthquake‐induced landslide scenarios for seismic microzonation. Application to the Accumoli area (Rieti, Italy) [PDF]

, 2019
Scenarios of earthquake-induced landslides are necessary for seismic microzonation (SM) studies since they must be integrated with the mapping of instability areas.
Battaglia, Simona, Della Seta, M., D’Alessandro, F., Esposito, Carlo, Martini, G., Martino, Salvatore, Pallone, F., Troiani, F.   +7 more
core   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Snow avalanche susceptibility in the eastern hillside of the Aramo Range (Asturian Central Massif, Cantabrian Mountains, NW Spain) [PDF]

, 2018
A detailed snow avalanche susceptibility map of the eastern hillside in the Aramo Range (Cantabrian Mountains) is presented at a scale of 1:25,000. The Aramo Range is one of the major middle-altitude mountains of the Asturian Central Massif.
Beato Bergua, Salvador, Marino Alfonso, José Luis, Poblete Piedrabuena, Miguel Ángel   +2 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Glacial geomorphology of the Gaick, Central Grampians, Scotland

Journal of Maps, 2019
The Gaick is an enigmatic glaciated landscape in the Central Grampians, Scotland, dominated by an expansive dissected plateau. Previous studies have postulated widely differing interpretations of the glacial landforms and current understanding of the ...
Benjamin M. P. Chandler, Sven Lukas, Clare M. Boston, Jon W. Merritt   +3 more
doaj   +1 more source

Progress in Geomorphological Mapping and Moravian Geomorphology

Geografie, 1969
The author deals in his paper with the problems of geomorphological mapping which bas become during last two decades one of the main methods of geomorphological research. He is of the opinion that the most important problem is at present the international unification of the methods of geomorphological mapping as well as the unification of the legends ...
openaire   +1 more source