Results 71 to 80 of about 42,320 (308)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Glacial geomorphology of the Ahuriri River valley, central Southern Alps, New Zealand

Journal of Maps, 2021
Detailed geomorphological mapping of ice-related and post-glacial landforms is widely used to explain past glacial fluctuations and dynamics. Here we present the first detailed glacial geomorphological description of the landform assemblages produced by ...
Levan G. Tielidze, Shaun R. Eaves, Kevin P. Norton, Andrew N. Mackintosh   +3 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Space-weighted seismic attenuation mapping of the aseismic source of Campi Flegrei 1983-84 unrest [PDF]

, 2017
Peer reviewedPublisher ...
Amoruso, A, Castellano, M, Crescentini, L, De Siena, L, Del Pezzo, E, Wakeford, Z   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multi-hazard risk assessment using GIS in urban areas: a case study for the city of Turrialba, Costa Rica [PDF]

, 2002
In the framework of the UNESCO sponsored project on “Capacity Building for Natural Disaster Reduction” a case study was carried out on multi-hazard risk assessment of the city of Turrialba, located in the central part of Costa Rica.
Badilla Coto, Elena, Boerboom, Luc, Montoya, Lorena, Westen, Cees J. van   +3 more
core   +6 more sources

Techniques, problems and uses of mega-geomorphological mapping [PDF]

A plea for a program of global geomorphological mapping based on remote sensing data is presented. It is argued that the program is a necessary step in bringing together the rapidly evolving concepts of plate tectonics with the science of geomorphology ...
Embleton, C.
core   +1 more source

Progress in Geomorphological Mapping and Moravian Geomorphology

Geografie, 1969
The author deals in his paper with the problems of geomorphological mapping which bas become during last two decades one of the main methods of geomorphological research. He is of the opinion that the most important problem is at present the international unification of the methods of geomorphological mapping as well as the unification of the legends ...
openaire   +1 more source