Piwi is required in multiple cell types to control germline stem cell lineage development in the Drosophila ovary. [PDF]
PLoS ONE, 2014 The piRNA pathway plays an important role in maintaining genome stability in the germ line by silencing transposable elements (TEs) from fly to mammals.
Xing Ma +21 more
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Effect of FSH on testicular morphology and spermatogenesis in gonadotrophin-deficient hypogonadal mice lacking androgen receptors [PDF]
, 2010 Follicle stimulating hormone (FSH) and androgen act to stimulate and maintain spermatogenesis. FSH acts directly on the Sertoli cells to stimulate germ cell number and acts indirectly to increase androgen production by the Leydig cells.
Abel, M.H. +4 more
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A pilgrim's progress: Seeking meaning in primordial germ cell migration
Stem Cell Research, 2017 Comparative studies of primordial germ cell (PGC) development across organisms in many phyla reveal surprising diversity in the route of migration, timing and underlying molecular mechanisms, suggesting that the process of migration itself is conserved ...
Andrea V. Cantú, Diana J. Laird
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Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors [PDF]
, 2016 Type II germ cell tumors arise after puberty from a germ cell that was incorrectly programmed during fetal life. Failure of testicular germ cells to properly differentiate can lead to the formation of germ cell neoplasia in situ of the testis; this ...
Bowles, J. (Josephine) +6 more
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Mitotic arrest in teratoma susceptible fetal male germ cells. [PDF]
PLoS ONE, 2011 Formation of germ cell derived teratomas occurs in mice of the 129/SvJ strain, but not in C57Bl/6 inbred or CD1 outbred mice. Despite this, there have been few comparative studies aimed at determining the similarities and differences between teratoma ...
Patrick S Western +6 more
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Cooperative cell–cell actin network remodeling to perform Gap junction endocytosis
Basic and Clinical Andrology, 2023 Background The endocytosis of Gap junction plaques (GJP) requires cytoskeletal forces to internalize such large membranous structures. Actin, which partners the connexin proteins constituting Gap junctions and is located close to Annular Gap Junctions ...
Dominique Segretain +5 more
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Plasma and testicular testosterone levels, volume density and number of Leydig cells and spermatogenic efficiency of rabbits [PDF]
, 2002 Plasma and tissue testosterone concentrations were determined by radioimmunoassay in 12 eight-month-old sexually mature New Zealand White rabbits and evaluated for possible associations with spermatogenic efficiency as well as with volume density and ...
Berndtson, William E. +2 more
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Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells. [PDF]
PLoS ONE, 2016 The mechanisms underlying human germ cell development are largely unknown, partly due to the scarcity of primordial germ cells and the inaccessibility of the human germline to genetic analysis.
Sarita Panula +12 more
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Establishment of pluripotent cell lines from vertebrate species - Present status and future prospects [PDF]
, 1999 Pluripotent embryonic stem (ES) cells are undifferentiated cell lines derived from early embryos and are capable of unlimited undifferentiated proliferation in vitro.
Prelle, Katja +4 more
core +1 more source
Surgical treatment of metastatic germ cell cancer
Asian Journal of Urology, 2021 Among young men between the ages of 15 and 40 years, germ cell cancer is the most common solid tumor [1]. The worldwide incidence of germ cell cancer is 70 000 cases.
Andreas Hiester, Peter Albers
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