Results 131 to 140 of about 24,196 (383)

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Peculiarities in formation of Arabidopsis Thaliana (L.) Heynh, generative organs under space flight conditions [PDF]

Peculiarities in the formation of the andrecium and gynecium elements are described for Arabidopsis plants grown from the stages of two cotyledonous leaves in the Svitoblok-1 device on board the Salyut 6 orbital research station and in the laboratory. It
Chernyayeva, I. I., Kordyum, Y. L.
core   +1 more source

Rare complication of chemotherapy in testicular cancer [PDF]

, 2009
Testicular neoplasms metastasizing to the retroperitoneum rarely involve the upper gastrointestinal tract. We describe an unusual case of contained small bowel perforation as a complication of chemotherapy treatment of metastatic non seminomatous germ ...
Goad Abdel Helmy Ehab
core   +1 more source

Single‐Cell Mitochondrial Lineage Tracing Decodes Fate Decision and Spatial Clonal Architecture in Human Hematopoietic Organoids

Advanced Science, EarlyView.
This study repurposes mitochondrial DNA mutations as endogenous barcodes for lineage tracing in human pluripotent stem cell‐derived organoids. Integrated with transcriptomic and spatial data, it reveals NOTCH‐mediated stromal‐progenitor crosstalk orchestrates clonal dynamics and spatial zonation during early hematopoietic development, offering a non ...
Yan Xue, Junhao Su, Yiming Chao, Lu Liu, Xinyi Lin, Yang Xiang, Mun Kay Ho, Zezhuo Su, Junyi Chen, Zhuojuan Luo, Chengqi Lin, Ruibang Luo, Theo Aurich, Jianfeng Wu, Kelvin Sin Chi Cheung, Yuanhua Huang, Joshua W. K. Ho, Ryohichi Sugimura   +17 more
wiley   +1 more source

Gilbert et al Suppl data from Defining a New Prognostic Index for Stage I Nonseminomatous Germ Cell Tumors Using CXCL12 Expression and Proportion of Embryonal Carcinoma

, 2023
Duncan C. Gilbert, Reem Al‐Saadi, Khin Thway, Ian Chandler, Daniel M. Berney, Rhian Gabe, Sally Stenning, Joan Sweet, Robert Huddart, Janet Shipley   +9 more
openalex   +2 more sources

Management of germ cell tumors in children: Approaches to cure [PDF]

, 2002
The introduction of cisplatinum chemotherapy and current advances in the surgical treatment have resulted in a dramatic improvement of the prognosis of children with malignant germ cell tumors (GCT).
Calaminus, G., Göbel, U., Haas, R. J., Schmidt, P., Schneider, D. T.   +4 more
core   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Gastric teratoma in a 6-month-old boy

African Journal of Paediatric Surgery, 2012
Gastric teratomas are very rare embryonal neoplasms, accounting for 2.6% of all perinatal diagnosed germ cell tumours. About 85% are well-differentiated mature lesions and about 15% are immature tumours with the potential of malignant transformation. The
Peer Wildbrett, Hagen Graf Einsiedel, Björn Lange, Holger Lode, Winfried Barthlen   +4 more
doaj   +1 more source

Natural Variations of ZmRLR1 Mediate the Root Lodging Resistance of Maize by Regulating Root Ascorbate and Auxin Homeostasis

Advanced Science, EarlyView.
Root lodging severely limits crop yield and quality. We reveal that ZmRLR1, a plasma membrane b‐type cytochrome, regulates lodging resistance in maize through dual roles: modulating intracellular redox balance and functioning as a novel component of clathrin‐mediated endocytosis to influence auxin homeostasis. Moreover, natural variations in the ZmRLR1
Wenshuai Lv, Pengshuai Yan, Huan Chen, Guangxian Li, Yiyue Zhao, Yanhui Chen, Wen‐Xue Li, Qingguo Du   +7 more
wiley   +1 more source

Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients [PDF]

, 2009
Background. Tumours with high proportions of differentiated cells are considered to be of a lower grade to those containing high proportions of undifferentiated cells.
Alexandros Laios, Cara M Martin, Jamie K McInerney, Jinghuan Li, John J O'Leary, Kai Q Lao, Karen Denning, Mathia YC Lee, Michael F Gallagher, Orla M Sheils, Paul C Smyth, Richard J Flavin, Salah A Elbaruni, Sebastian F Vencken, Sharon A O'Toole, Sinead T Aherne, Yvonne M Salley   +16 more
core   +1 more source