Results 111 to 120 of about 12,778 (301)

Recent Developments in Testicular Germ Cell Tumor Research [PDF]

, 2009
Testicular germ cell tumors of adolescents and adults (TGCTs; the so-called type II variant) are the most frequent malignancies found in Caucasian males between 20 and 40 years of age, The incidence has increased over the last decades.
Hersmus, Remko, Looijenga, LHJ (Leendert), van de Geijn, GJM, Hersmus, Remko; id_orcid   +3 more
core   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

Derivation and characteristics of pluripotent embryonic germ cells in duck

Poultry Science, 2010
Embryonic germ (EG) cells derived from primordial germ cells are undifferentiated and pluripotent stem cells. In our study, primordial germ cells isolated from the genital ridges of Beijing duck (Anas domestica) embryo at stage 28 were co-cultured with mice embryonic fibroblasts.
W, Guan, Y, Wang, L, Hou, L, Chen, X, Li, W, Yue, Y, Ma   +6 more
openaire   +2 more sources

Met astatic Mixed Germ Cell Tumour with Embryonal Carcinoma and Choriocarcinoma in a Female Eurasian Harvest Mouse (Micromys minutus)

, 2020
Mixed germ cell tumours occur rarely in veterinary species. This report describes a case of metastatic mixed germ cell tumour in a female Eurasian harvest mouse (Mycromis minutus).
J. G. Trupkiewicz, L. Minoli, B. N. Ranieri, M. E. Church, J. C. Tarrant, E. Radaelli, C. A. Assenmacher   +6 more
core   +1 more source

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

Advanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li, Jialuo Xu, Gaoyuan Du, Xiangting Jia, Dongmin Zhao, Chunyan Zhou, Kexin Xiao, Jia Gu, Junnan Zhu, Xuequn Shang   +9 more
wiley   +1 more source

Gastric teratoma in a 6-month-old boy

African Journal of Paediatric Surgery, 2012
Gastric teratomas are very rare embryonal neoplasms, accounting for 2.6% of all perinatal diagnosed germ cell tumours. About 85% are well-differentiated mature lesions and about 15% are immature tumours with the potential of malignant transformation. The
Peer Wildbrett, Hagen Graf Einsiedel, Björn Lange, Holger Lode, Winfried Barthlen   +4 more
doaj   +1 more source

Glucosinolate and Isothiocyanate Profiles in Different Varieties of Raphanus sativus Seed via Multivariate Data Analysis

AgriFood: Journal of Agricultural Products for Food, EarlyView.
Through HPLC–MS/MS analysis and multivariate statistics, raphani semen (RS) varieties with high functional components were screened. The white raphani semen “Xuebawang” was identified as ideal for further study due to its high bioactive content: glucoraphenin (9010.27 mg/100 g), glucoraphanin (1027.76 mg/100 g), sulforaphane (66.14 mg/100 g), and ...
Yonghua Li, Dongmei Lin, Peng Wu, Rui Gao, Jingxiu Bi, Yuying Jiang, Tong Zhao, Xuexia Yuan, Jianhan Xu, Pingxiang Liu, Yutao Wang   +10 more
wiley   +1 more source

The overexpression of SOX2 affects the migration of human teratocarcinoma cell line NT2/D1

Anais da Academia Brasileira de Ciências, 2015
The altered expression of the SOX2 transcription factor is associated with oncogenic or tumor suppressor functions in human cancers. This factor regulates the migration and invasion of different cancer cells.
DANIJELA DRAKULIC, JELENA MARJANOVIC VICENTIC, MARIJA SCHWIRTLICH, JELENA TOSIC, ALEKSANDAR KRSTIC, ANDRIJANA KLAJN, MILENA STEVANOVIC   +6 more
doaj   +1 more source

Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency

, 2018
Testicular teratomas result from anomalies in embryonic germ cell development. In 129 inbred mice, teratoma initiation coincides with germ cell sex-specific differentiation and the mitotic-meiotic switch: XX and XY germ cells repress pluripotency, XX ...
Susan M. Benton, Emily P. Dawson, Denise G. Lanza, Nicholas J. Webster, Isao Suetake, Jason D. Heaney   +5 more
core   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source