Results 121 to 130 of about 248,167 (261)

A Nanos3-containing protein complex can activate RNA translation in primordial germ cells in vivo. [PDF]

EMBO Rep
Gupta A, Basaran AM, Ophaus M, Madiwale S, Stehling M, Reichman-Fried M, Tarbashevich K, Raz E.   +7 more
europepmc   +1 more source

Stem Cell Differentiation Disperses Transcriptional Clusters via a Conserved Surface‐Condensate Trajectory

Advanced Science, EarlyView.
Stem cell differentiation follows a conserved surface condensate trajectory: H3K27ac super enhancers nucleate large RNA polymerase II clusters that grow and unfold before transcriptional activity disperses them. This work reveals how biophysical forces at enhancer surfaces dynamically build and dismantle stem cell transcription hubs, reshaping cell ...
Tim Klingberg, Irina Wachter, Agnieszka Pancholi, Matthias Akyel, Yomna Gohar, Priya Kumar, Ana Miguel Fernandes, Yuzhi Bao, Alica Schmidt‐Heydt, Marcel Piepers, Alicia Günthel, Marcel Sobucki, Elisa Kämmer, Süheyla Eroğlu‐Kayıkçı, Stephan Allgeier, Sylvia Erhardt, Vasily Zaburdaev, Carmelo Ferrai, Lennart Hilbert   +18 more
wiley   +1 more source

ATAC-seq of low-input and cryopreserved primordial germ cells reveals functional enhancers. [PDF]

Development
Kawaguchi A, Igari M, Murayama Y, Iikawa H, Sakamoto M, Nakamura Y, Kuraku S, Ishihara K, Saito D.   +8 more
europepmc   +1 more source

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

Advanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li, Jialuo Xu, Gaoyuan Du, Xiangting Jia, Dongmin Zhao, Chunyan Zhou, Kexin Xiao, Jia Gu, Junnan Zhu, Xuequn Shang   +9 more
wiley   +1 more source

Reconstitution of spermatogenesis and continuous generation of functional haploid germ cells in mouse testicular organoids. [PDF]

Nat Commun
Wan C, Li Q, Yao Z, Ye Z, Zhao J, Ren S, Xue X, Tang K, Rao Q, Weng Y, Xu H, Wang W, Zhong C, Li X, Yang X, Pan M, Cui M, Ma L, Chen D, Li C, Zheng Z, Zheng Y, Liu Z, Chang G, Miao K, Luo F, Zhao XY.   +26 more
europepmc   +1 more source

A Conserved DT2‐bZIP66‐NF‐YC4 Regulatory Module Confers Drought Tolerance in Rice and Arabidopsis

Advanced Science, EarlyView.
This study identifies a conserved tripartiteDT2–bZIP66–NF‐YC4 transcriptional module that enhances rice drought tolerance by activating stress‐responsive genes. This regulatory complex is functionally conserved across cereals and Arabidopsis, providing promising targets for engineering drought‐resilient crops. ABSTRACT Drought stress severely restricts
Jun Shen, Yuchen Li, Liang Zhang, Xiaosong Ma, Chenyin Peng, Chunting Yuan, Yu Wu, Kaiyu Zhao, Sheng Zhao, Jiazhuo Guo, Run Li, Ziqian Yan, Shule Ren, Yige Han, Xin Lin, Xinyue Li, Ming Li, Pingfang Yang, Shiyong Song   +18 more
wiley   +1 more source

Analysis of Transcriptome and Differentially Expressed Genes in Chicken Primordial Germ Cells. [PDF]

Animals (Basel)
Azovtseva AI, Ryabova AE, Dysin AP, Peglivanyan GK, Reinbach NR, Gabova AV, Barkova OY, Polteva EA, Larkina TA.   +8 more
europepmc   +1 more source

Germ Cells

, 2006
erm cell development in mammalian gametogenesis involves a complex sequence of events regulated by a large variety of molecules. Although hormones have been always considered the primary regulators of gametogenesis, it is now well established that ...
DE FELICI, MASSIMO, Rossi, P, ROSSI, PELLEGRINO, Farini, D, Dolci, S, DOLCI IANNINI, SUSANNA, De Felici, M, FARINI, DONATELLA   +7 more
core  

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton

Advanced Science, EarlyView.
Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang, Jie Dai, Ting Zhao, Shengjun Zhao, Hongyu Wu, Jiaying Pan, Yupeng Hao, Ke Nie, Li Yu, Yumeng Zhu, Xiangyi Zhao, Kai Huang, Mengke Zhang, Yongyan Zhao, Yaping Jiang, Siyuan Wang, Yiling Pan, Yubing Chen, Yilai Lin, Wanghong Shi, Yayuan Deng, Jin Han, Jie Li, Xuan Long, Junbin Wang, Zhiyuan Zhang, Zegang Han, Zhanfeng Si, Lei Ju, Jun Li, Tianzhen Zhang, Ji Zhou, Xueying Guan   +32 more
wiley   +1 more source

High genotoxicity of CRISPR/Cas9 versus limited efficacy of CRISPRi in chicken primordial germ cells. [PDF]

Poult Sci
Zhang C, Wang M, He B, Yang X, Li XZ.
europepmc   +1 more source