On the development of extragonadal and gonadal human germ cells [PDF]
Biology Open, 2016 Human germ cells originate in an extragonadal location and have to migrate to colonize the gonadal primordia at around seven weeks of gestation (W7, or five weeks post conception).
A. Marijne Heeren +8 more
doaj +6 more sources
Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
Nature Medicine, 2012 Germline stem cells that produce oocytes in vitro and fertilization-competent eggs in vivo have been identified in and isolated from adult mouse ovaries.
Dori C Woods +2 more
exaly +2 more sources
Reconstitution of the Mouse Germ Cell Specification Pathway in Culture by Pluripotent Stem Cells
Cell, 2011 Katsuhiko Hayashi +2 more
exaly +2 more sources
Cell-fate transition and determination analysis of mouse male germ cells throughout development
Nature Communications, 2021 Mammalian male germ cell development is a stepwise cell-fate transition process; however, the full-term developmental profile of male germ cells remains undefined.
Jiexiang Zhao +20 more
semanticscholar +1 more source
SGK1 is essential for meiotic resumption in mammalian oocytes
European Journal of Cell Biology, 2022 In mammalian females, oocytes are stored in the ovary and meiosis is arrested at the diplotene stage of prophase I. When females reach puberty oocytes are selectively recruited in cycles to grow, overcome the meiotic arrest, complete the first meiotic ...
Edgar del Llano +8 more
doaj +1 more source
Oocyte specific lncRNA variant Rose influences oocyte and embryo development
Non-coding RNA Research, 2021 Fully grown mammalian oocytes store a large amount of RNA synthesized during the transcriptionally active growth stage. A large part of the stored RNA belongs to the long non-coding class which contain either transcriptional noise or important ...
Rajan Iyyappan +5 more
doaj +1 more source
Strategies for Mammalian Mesenchymal Stem Cells Differentiation into Primordial Germ Cell-Like Cells: A Review [PDF]
Cell Journal, 2022 Primordial germ cells develop into oocytes and sperm cells. These cells are useful resources in reproductive biology and regenerative medicine. The mesenchymal stem cells (MSCs) have been examined for in vitro production of primordial germ cell-like ...
Shabnam Fayezi +3 more
doaj +1 more source
Metabolic pathways regulating the development and non-genomic heritable traits of germ cells
The Journal of Reproduction and Development, 2021 Metabolism is an important cellular process necessary not only for producing energy and building blocks for cells, but also for regulating various cell functions, including intracellular signaling, epigenomic effects, and transcription.
Yasuhisa MATSUI, Yohei HAYASHI
doaj +1 more source
In vitro germ cell differentiation from cynomolgus monkey embryonic stem cells. [PDF]
PLoS ONE, 2009 BACKGROUND: Mouse embryonic stem (ES) cells can differentiate into female and male germ cells in vitro. Primate ES cells can also differentiate into immature germ cells in vitro.
Kaori Yamauchi +4 more
doaj +1 more source
Cyp26b1 expression in murine Sertoli cells is required to maintain male germ cells in an undifferentiated state during embryogenesis. [PDF]
PLoS ONE, 2009 In mammals, germ cells within the developing gonad follow a sexually dimorphic pathway. Germ cells in the murine ovary enter meiotic prophase during embryogenesis, whereas germ cells in the embryonic testis arrest in G0 of mitotic cell cycle and do not ...
Hui Li +4 more
doaj +1 more source