Results 81 to 90 of about 11,116,441 (355)
NOTCH1 Gain of Function in Germ Cells Causes Failure of Spermatogenesis in Male Mice [PDF]
, 2013 NOTCH1 is a member of the NOTCH receptor family, a group of single-pass trans-membrane receptors. NOTCH signaling is highly conserved in evolution and mediates communication between adjacent cells.
Agoulnik, Alexander I. +2 more
core +3 more sources
PLoS ONE, 2013 A number of environmental factors (e.g. toxicants) have been shown to promote the epigenetic transgenerational inheritance of disease and phenotypic variation.
M. Skinner +4 more
semanticscholar +1 more source
HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein
FEBS Open Bio, EarlyView.Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley +1 more source
Production of live fish derived from frozen germ cells via germ cell transplantation
Stem Cell Research, 2018 The conservation of endangered fish is an urgent issue. Although cryo-banking of fish gametes might ultimately help conserve endangered fish, cryopreservation of fish eggs or embryos is still not possible due to their large size and high yolk content ...
Goro Yoshizaki, Seungki Lee
doaj +1 more source
Doxorubicin Affects Testicular Lipids with Long-Chain (C18-C22) and Very Long-Chain (C24-C32) Polyunsaturated Fatty Acids [PDF]
, 2007 Doxorubicin disrupts spermatogenesis by causing apoptosis of spermatogonia and primary spermatocytes. The aim of this study was to examine the effect of this agent on adult rat testicular lipids and their fatty acids.
Aveldaño, Marta Isabel +2 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin +11 more
wiley +1 more source
Actomyosin-mediated apical constriction promotes physiological germ cell death in C. elegans.
PLoS BiologyGerm cell apoptosis in Caenorhabditis elegans hermaphrodites is a physiological process eliminating around 60% of all cells in meiotic prophase to maintain tissue homeostasis. In contrast to programmed cell death in the C.
Tea Kohlbrenner +6 more
doaj +1 more source
Primordial Germ Cell Specification and Migration [version 1; referees: 3 approved]
F1000Research, 2015 Primordial germ cells are the progenitor cells that give rise to the gametes. In some animals, the germline is induced by zygotic transcription factors, whereas in others, primordial germ cell specification occurs via inheritance of maternally provided ...
Florence Marlow
doaj +1 more source
Classical gonadoblastoma: its relationship to the “dissecting” variant and undifferentiated gonadal tissue [PDF]
, 2017 Classical gonadoblastoma occurs almost entirely in the dysgenetic gonads of an individual who has a disorder of sex development. Approximately 40% of such neoplasms are bilateral.
Cheng, Liang, Roth, Lawrence M.
core +2 more sources
Frontiers in Cell and Developmental Biology, 2018 Germ cell research in vertebrates has traditionally been challenging, but recent breakthroughs have overcome technical difficulties, demonstrating and expanding the power of the zebrafish experimental system for their analysis in vivo. Exploiting the transparency of the zebrafish embryo, germ cell migration was the first topic that moved the germ cells
Roland Dosch, Roland Dosch
openaire +4 more sources