Results 181 to 190 of about 32,670 (210)

Spermatogenesis Beyond DNA: Integrated RNA Control of the Epitranscriptome and Three-Dimensional Genome Architecture. [PDF]

Curr Issues Mol Biol
Kaltsas A, Kyrgiafini MA, Mamuris Z, Chrisofos M, Sofikitis N.   +4 more
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Study of Stress Granule Core Protein AtUBP1b Phosphorylation <i>In Vitro</i>. [PDF]

Plants (Basel)
Nizkorodova AS, Kislitsin VY, Zhigailov AV, Kulyyassov AT, Nadirova LM, Stanbekova GE, Iskakov BK.   +6 more
europepmc   +1 more source

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How germ granules promote germ cell fate

Nature Reviews Genetics
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble membraneless germ granules. These specialized RNA and protein complexes are hallmarks of germ cells throughout their life cycle: as embryonic germ granules in late oocytes and zygotes, Balbiani bodies in immature ...
Melissa C. Pamula, Ruth Lehmann
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Mitochondrial granule distribution in tooth germ cells

The Anatomical Record, 1977
AbstractIncisor and molar tooth germs of albino rats sacrificed at the eighteenth and twentieth days in utero and one to seven days after birth were studied with light and electron microscopy. Observations of the various stages of tooth development in molars established that intramitochondrial granules in odontoblasts were comparable to the ...
F S, Sayegh, A, Abousy
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Germ granules and the control of mRNA translation

IUBMB Life, 2012
AbstractGerm granules are an evolutionarily conserved feature of germ cell cytoplasm and are critical for gametogenesis and embryonic development. Germ granules are highly enriched for RNA and RNA‐binding proteins and are key centers for post‐transcriptional gene regulation in germ cells.
Madhu S, Sengupta, Peter R, Boag
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Bioinformatic analysis of P granule-related proteins: insights into germ granule evolution in nematodes

Development Genes and Evolution, 2010
Germ cells in many animals possess a specialized cytoplasm in the form of granules that contain RNA and protein complexes essential for the function and preservation of the germline. The mechanism for the formation of these granules is still poorly understood; however, the lack of conservation in their components across different species suggests ...
Luis A, Bezares-Calderón, Arturo, Becerra, Laura S, Salinas, Ernesto, Maldonado, Rosa E, Navarro   +4 more
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Peripheral but critical: Translation of germ granule mRNAs in zebrafish

Developmental Cell, 2023
RNA granule components occupy distinct positions within granules. However, the significance behind this organization is unclear. In this issue of Developmental Cell, Westerich et al. show that the periphery of the zebrafish germ granules promotes mRNA translation while its interior represses it, which is critical for germ cell establishment.
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Repressor sequestration activates translation of germ granule localized mRNA

2023
AbstractBiomolecular condensates organize and compartmentalize biochemical processes within cells1. Among these, ribonucleoprotein (RNP) granules are characterized as storage depots for translationally repressed mRNA2–8. Whether RNP granules can also activate translation and how such translation is achieved remains unclear9.
Ruoyu Chen, William Stainier, Jeremy Dufourt, Mounia Lagha, Ruth Lehmann   +4 more
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Germ granule higher-order organization coordinates their different functions

2023
AbstractMost RNP condensates are composed of heterogeneous immiscible phases. However, how this multiphase organization contributes to their biological functions remains largely unexplored.Drosophilagerm granules, a class of RNP condensates, are the site of mRNA storage and translational activation.
Anne Ramat, Ali Haidar, Céline Garret, Martine Simonelig   +3 more
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Germ cell development: Polar granules and PIPs — best buds forever

Current Biology
Germ granules are specialized RNA-protein condensates that drive germ cell development. A new study reveals that germ granules promote Drosophila germ cell formation by altering membrane mechanics through PIP2 and actin.
Marynelle S, Icmat, Julie A, Brill
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