Results 171 to 180 of about 9,538 (205)

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, EarlyView.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Pre-marking chromatin with H3K4 methylation is required for accurate zygotic genome activation and development. [PDF]

Nat Commun
Oak MS, Stock M, Janeva A, Mezes M, Hynes-Allen AM, Straub T, Forné I, Ettinger A, Hamperl S, Imhof A, van den Ameele J, Scialdone A, Hörmanseder E.   +12 more
europepmc   +1 more source

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

crossNN is an explainable framework for cross-platform DNA methylation-based classification of tumors. [PDF]

Nat Cancer
Yuan D, Jugas R, Pokorna P, Sterba J, Slaby O, Schmid S, Siewert C, Osberg B, Capper D, Halldorsson S, Vik-Mo EO, Zeiner PS, Weber KJ, Harter PN, Thomas C, Albers A, Rechsteiner M, Reimann R, Appelt A, Schüller U, Jabareen N, Mackowiak S, Ishaque N, Eils R, Lukassen S, Euskirchen P.   +25 more
europepmc   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

PLA2G16‐Mediated Tetracosatetraenoic Acid Rewires Fatty Acid Oxidation to Impair CD8+ T Cell Immune Function in Promoting Breast Cancer Lung Metastasis

Advanced Science, EarlyView.
Illustrating how tumor‐derived PLA2G16 regulates tetracosatetraenoic acid (C24:4 (n‐6)) accumulation and CD8+ T cell activation via the C24:4‐PPARα‐FAO axis in early metastatic niches, thereby promoting lung metastasis of triple‐negative breast cancer.
Yubi Gan, Die Meng, Lei Lang, Jing Luo, Peijin Dai, Chao Chang, Zexiu Lu, Yuetong Guo, Rui Wang, Shanchun Chen, Xi Tang, Yixuan Hou, Dongmei Tan, Manran Liu   +13 more
wiley   +1 more source

Direct RNA sequencing enables improved transcriptome assessment and tracking of RNA modifications for medical applications. [PDF]

Nucleic Acids Res
Hewel C, Wierczeiko A, Miedema J, Friedrich J, Hofmann F, Weißbach S, Dietrich V, Holthöfer L, Haug V, Mündnich S, Schartel L, Lehmann L, Jensen KL, Diederich S, Sys S, Butto T, Paul NW, Koch J, Lyko F, Kraft F, Russo A, Schweiger S, Lemke EA, Helm M, Linke M, Gerber S.   +25 more
europepmc   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

A transgenic mouse model for reticulated platelet detection reveals expansion after myocardial ischemia/reperfusion. [PDF]

Blood Vessel Thromb Hemost
Hamad MA, Schanze N, Krauel K, Lother A, Perez-Feliz S, Iaconianni P, Zurek M, Almushkab L, Madl J, Hollenhorst MA, Kohl P, Nührenberg TG, Duerschmied D.   +12 more
europepmc   +1 more source

Immune Training of the Interleukin 6 Gene in Airway Epithelial Cells is Central to Asthma Exacerbations. [PDF]

Allergy
Lunding LP, Weckmann M, Zissler UM, Jakwerth C, Bodenstein-Sgró R, Webering S, Vock C, Ehlers JC, Fernandez Ceballos RAM, Nemani SSP, Reddy KD, Oliver BGG, Vermeulen CJ, van de Berge M, Ober C, Künstner A, Busch H, König I, Garbers C, Schmidt-Weber CB, Nold MF, Yildirim AÖ, Nold-Petry CA, Orinska Z, Bahmer T, Heyckendorf J, Hansen G, von Mutius E, Rabe KF, Dittrich AM, Schaub B, Brinkmann F, Kopp MV, Wegmann M, ALLIANCE Study Group as part of the German Centre for Lung Research (DZL).   +34 more
europepmc   +1 more source