Results 171 to 180 of about 9,094 (207)

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source

Unraveling Relatlimab-Specific Biology Using Biomarker Analyses in Patients with Advanced Melanoma in RELATIVITY-047. [PDF]

Clin Cancer Res
Lipson EJ, Dolfi S, Tang H, Tawbi HA, Medina-Soto F, Castillo Gutiérrez E, Rutkowski P, Gogas H, Murillo E, Ascierto PA, Desai K, Maio M, Demers K, Mazzei A, Keidel S, Miller-Moslin K, Yu JX, Hodi FS, Schadendorf D, Long GV, Garnett-Benson C.   +20 more
europepmc   +1 more source

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

Advanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li, Rui Wang, Wenting Luo, Hui Gu, Tianchu Huang, Qiushi Wang, Zhengwei Yuan   +6 more
wiley   +1 more source

Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development. [PDF]

Nat Ecol Evol
Schindler M, Feregrino C, Aldrovandi S, Lo BW, Monaco AA, Ringel AR, Morales AE, Zehnder T, Behncke RY, Glaser J, Barclay A, Andrey G, Kragesteen BK, Hägerling R, Haas SA, Vingron M, Ulitsky I, Marti-Renom MA, Hechavarria J, Fasel N, Hiller M, Lupiáñez DG, Mundlos S, Real FM.   +23 more
europepmc   +1 more source

Movement Mechanisms Harness Lévy Flight for Energy‐Efficient Wastewater Treatment in Microalgae–Bacteria Systems

Advanced Science, EarlyView.
Here, our novel model that integrates metabolism with motility dynamics reveals that microalgae shift bacterial movement toward Lévy flight patterns, enhancing encounter rates and self‐aggregation. This microecological manipulation reduces energy costs, strengthens functions such as pollutant removal and system stability.
Luyu Zhang, Yu Tian, Lipin Li, Wei Zhan, Huihang Sun, Nanqi Ren, Zhurui Tang, Huu Hao Ngo   +7 more
wiley   +1 more source

Pruritus Is an Indicator for Quality of Life in Cutaneous T-Cell Lymphoma. [PDF]

J Dermatol
Roggo A, Wüest Y, Dummer R, Ramelyte E.
europepmc   +1 more source

Oncogene aberrations drive medulloblastoma progression, not initiation. [PDF]

Nature
Okonechnikov K, Joshi P, Körber V, Rademacher A, Bortolomeazzi M, Mallm JP, Vaillant J, da Silva PBG, Statz B, Sepp M, Sarropoulos I, Yamada T, Wittmann A, Schramm K, Blattner-Johnson M, Fiesel P, Jones B, Jäger N, Milde T, Pajtler KW, van Tilburg CM, Witt O, Bochennek K, Weber KJ, Nonnenmacher L, Reimann C, Ghasemi DR, Schüller U, Mynarek M, Rutkowski S, Jones DTW, Korshunov A, Rippe K, Westermann F, Thongjuea S, Höfer T, Kaessmann H, Kutscher LM, Pfister SM.   +38 more
europepmc   +1 more source

A qualitative interview study on psycho-oncologists' experiences with patient deaths in Germany. [PDF]

Sci Rep
Wandke S, Brandes L, Rutenkröger M, Führes H, Lang K, Härter M, Oechsle K, Bokemeyer C, Scholl I.   +8 more
europepmc   +1 more source

Enhancing the intraoperative identification of high-grade patterns in invasive lung adenocarcinoma via radiomics. [PDF]

Transl Lung Cancer Res
Sun Y, Dong H, Jin W, Xuan H, Yuan Z, Käsmann L, Shen L, Wang T, Ye X, Zeng M.   +9 more
europepmc   +1 more source

Frequency of safety signals from scientific reports, manufactures, registers, and other sources for a random selection of hip and knee prostheses. [PDF]

Acta Orthop
Ren Y, Hoogervorst LA, Caiani EG, Marang-van de Mheen PJ, Smith JA, Fraser AG, Nelissen RGHH, Lübbeke A.   +7 more
europepmc   +1 more source