Results 181 to 190 of about 133,668 (277)

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Cell cycle regulator MYBL2 is a distinct vulnerability in acute myeloid leukemia. [PDF]

Cell Death Discov
Küchler S, Brilloff S, Schäfer S, Rahimian E, Kufrin V, Peri SS, Musa J, Grünewald TGP, Schewe DM, Ball CR, Bornhäuser M, Glimm H, Bill M, Wurm AA.   +13 more
europepmc   +1 more source

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science, EarlyView.
Oxidative phosphorylation (OXPHOS) activity serves as a critical metabolic determinant of radiotherapy outcomes in esophageal squamous cell carcinoma (ESCC). The CEBPB/AREG/EREG axis drives radioresistance in ESCC by reprogramming OXPHOS. AREG and EREG function as predictive biomarkers for nCRT response and prognosis of ESCC patients.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
wiley   +1 more source

Evaluating Web Retrieval-Assisted Large Language Models With and Without Whitelisting for Evidence-Based Neurology: Comparative Study.

J Med Internet Res
Masanneck L, Epping PZ, Meuth SG, Pawlitzki M.   +3 more
europepmc   +1 more source

DNMT3A-dependent DNA methylation shapes the endothelial enhancer landscape. [PDF]

Nucleic Acids Res
Gehrs S, Gu Z, Hey J, Weichenhan D, Buckwalter N, Jakab M, Hotz-Wagenblatt A, Breuer K, Prada ML, Hübschmann D, Schlereth K, Plass C, Augustin H.   +12 more
europepmc   +1 more source

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, EarlyView.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

Evidence for early circulation of the M1UK sublineage of Streptococcus pyogenes in Germany, 2015-2023. [PDF]

Emerg Microbes Infect
Rößler S, Boutin S, Berner R, Tomidis Chatzimanouil MK, Belheouane M, Rupp J, Merker M, Dresden GAS Study Group, Töpfner N, Nurjadi D.   +9 more
europepmc   +1 more source

Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney

Advanced Science, EarlyView.
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu, Hong Zhang, Shanzhi Yang, Jiaoqing Li, Danfeng Wu, Haosen Xu, Huan Jiang, Yi Jing, Guoxiang Jin, Ruobing Liu, Ning Fan, Xiaoyan Bai   +11 more
wiley   +1 more source

TTV Species Diversity as a Novel Biomarker of Immune Dysregulation in Aging. [PDF]

J Med Virol
Novazzi F, Spezia PG, Ferrante FD, Genoni AP, Grossi PA, Mancini N, Malavolta M, Ballietti M, Piacenza F, Marcozzi S, Fortunato C, Badillo Pazmay GV, Cianfruglia L, Bürkle A, Moreno-Villanueva M, Dollé MET, Jansen E, Grune T, Gonos ES, Franceschi C, Capri M, Zampieri M, Caiafa P, Ciccarone F, Reale A, Weinberger B, Sikora E, Debacq-Chainiaux F, Stuetz W, Hurme M, Slagboom PE, Bernhardt J, Olivieri F, Filippini F, Maggi F, Giacconi R.   +35 more
europepmc   +1 more source

Constructing Dual‐Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration

Advanced Science, EarlyView.
A novel bimetallic nanozyme (Fe2–NCs) with well‐defined Fe–Fe active sites is synthesized through a host–guest coordination strategy, which exhibits an exceptional therapeutic efficacy in osteoarthritis therapy. Experimental and theoretical analyses uncover the intrinsic catalytic mechanism at the atomic level, offering fundamental insights and design ...
Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu   +6 more
wiley   +1 more source