Results 211 to 220 of about 343,979 (290)

Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non‐Small Cell Lung Cancer Brain Metastasis

Advanced Science, EarlyView.
This study mainly combines spatial/single‐cell transcriptomics and metabolomics to reveal LOX+ Malig‐5 as NSCLC brain metastasis‐initiating cells, forming a niche with NET‐releasing neutrophils via the NET‐KRT10 axis. The metastatic niche is involved with metabolic reprogramming, with palmitic acid serving as a key metabolite.
Bo Chen, Karrie M. Kiang, Fangkun Liu, Chuntao Li, Xizhe Li, Chen Weiwei, Xin Fu, Gelei Xiao, Jingyi Sun, Erhan Da, Junbo Liao, Hongshu Zhou, Li Meng, Li Zhou, Tao Song, Longbo Zhang, Gilberto Ka‐Kit Leung, Liyang Zhang   +17 more
wiley   +1 more source

THE MEDICAL LIBRARY ASSOCIATION AND THE HIGH COST OF GERMAN MEDICAL PUBLICATIONS.

Bulletin of the Medical Library Association, 2006
openaire   +1 more source

Cortisol as a Mediator of Prenatal Distress and Difficult Infant Temperament: A Systematic Review and Meta-Analysis Protocol. [PDF]

Health Sci Rep
Sörensen F, Fransson E, Skalkidou A, Krägeloh-Mann I, Derntl B.   +4 more
europepmc   +1 more source

HPD is an m6A Methyltransferase that Protects Colorectal Cancer Cells from Ferroptotic Cell Death by m6A Methylating SLC7A11/GPX4

Advanced Science, EarlyView.
This study reveals that the tyrosine metabolic enzyme HPD functions as a previously uncharacterized, METTL3‐independent m6A methyltransferase. It promotes colorectal tumor progression by coordinately regulating the SLC7A11/GPX4 axis to suppress ferroptosis.
Jiyan Wang, Xintong Dai, Huanle Liu, Saiwei Hua, Hongkai Chang, Huanran Sun, Mingming Sun, Huifang Zhao, Kemin Ni, Fei Xie, Yaya Qiao, Qingle Gao, Chenxi Yu, Qijun Zhang, Jianshuang Guo, Chunze Zhang, Shuai Zhang, Changliang Shan   +17 more
wiley   +1 more source

Mitochondrial Glutathione Import Enables Breast Cancer Metastasis via Integrated Stress Response Signaling. [PDF]

Cancer Discov
Yeh HW, DelGaudio NL, Uygur B, Millet A, Khan A, Unlu G, Xiao M, Timson RC, Li C, Ozcan K, Smith KW, Nascentes Melo LM, Allies G, Basturk O, Sickmann A, Bayraktar EC, Possemato R, Tasdogan A, Birsoy K.   +18 more
europepmc   +1 more source

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source

AUTHENTIC TRANSLATION OF REPLY OF DEUTSCHER VERLEGERVEREIN TO RESOLUTION OF THE MEDICAL LIBRARY ASSOCIATION PROTESTING AGAINST THE HIGH PRICES OF GERMAN MEDICAL PUBLICATIONS.

Bulletin of the Medical Library Association, 2006
openaire   +1 more source

BabelFSH-a toolkit for an effective HL7 FHIR-based terminology provision. [PDF]

J Biomed Semantics
Wiedekopf J, Ohlsen T, Kock-Schoppenhauer AK, Ingenerf J.   +3 more
europepmc   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Sensor-based evaluation of intermittent fasting regimes: a machine learning and statistical approach. [PDF]

Int J Obes (Lond)
Steckhan N, Manlik T, Int-Veen T, Peters B, Pappe CL, Koppold DA, Arnrich B, Michalsen A, Dommisch H, Schwarz P, Pivovarova-Ramich O.   +10 more
europepmc   +1 more source