Results 311 to 320 of about 3,641,641 (357)
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Getting toGether in Germinal centers
Science Immunology, 2021Ggt5 cleaves the ligand of P2RY8 in lymph node follicles and generates a gradient that supports B cell confinement to germinal centers.
Liat Stoler-Barak, Ziv Shulman
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Science, 2010
The humoral immune response, which comprises antibodies secreted by B lymphocytes, is critical for protection against pathogens. In response to infection, B lymphocytes proliferate and differentiate into antibody-producing effector cells.
Caroline Ash, Maria Cruz
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The humoral immune response, which comprises antibodies secreted by B lymphocytes, is critical for protection against pathogens. In response to infection, B lymphocytes proliferate and differentiate into antibody-producing effector cells.
Caroline Ash, Maria Cruz
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Complement-in’ the germinal center response
Nature Immunology, 2021B cells rewire complement for optimal germinal center responses. When B cell C3 activity is limited, germinal centers collapse and outputs are impaired.
Marcus James Robinson +2 more
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Germinal centers develop oligoclonally
European Journal of Immunology, 1987AbstractAs part of our studies into the role of germinal centers, we investigated whether each de novo generated germinal center (GC) develops from one single GC precursor cell (GCPC, monoclonal development), a few GCPC (oligoclonal development) or from many GCPC (polyclonal development).
Auk S. Wubbena +3 more
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The life and death of the germinal center
Annals of Diagnostic Pathology, 2020The formation, development and dissolution of germinal centers is a major part of immune system function. It is important to differentiate neoplastic processes from follicular hyperplasia and regressive follicular changes. Better understanding of germinal center development and dissolution also provides diagnostic clues to the underlying pathologic ...
Robert S. Ohgami +4 more
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Functional anatomy of germinal centers
American Journal of Anatomy, 1984AbstractThis year we celebrate the first centennial of the discovery of germinal centers by Flemming in 1884. The present paper reviews and adds new data to the functional anatomy of a germinal center. Emphasizing its reactive nature, we first describe a germinal center reaction and then deal with its infrastructural aspects and constituent cell ...
Paul Nieuwenhuis, Davina Opstelten
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Repulsive behavior in germinal centers
Science, 2017B cell–T cell interactions are terminated by EPH receptors and ...
G. Leandros Moschovakis +1 more
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Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability.
Circulation, 2019BACKGROUND Atherosclerosis progression is modulated by interactions with the adaptive immune system. Humoral immunity can help protect against atherosclerosis formation; however, the existence, origin, and function of putative atherogenic antibodies are ...
M. Centa +20 more
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The dynamic structure of the germinal center
Immunology Today, 1998Analysis of germinal centers (GCs) in chronically inflamed human tonsils has led to the dogma that GCs contain two compartments with separate functions: a dark zone where B cells proliferate and hypermutate; and a light zone where selection and differentiation occur.
Claudia Berek +2 more
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Germinal center or nongerminal center DLBCL?
Nature Reviews Clinical Oncology, 2009Patients with a immunohistochemically defined, germinal-center tumor subtype have an improved outcome compared with patients with the non-germinal-center phenotype when treated with CHOP only, according to a prospective study. The benefit was not observed in those treated with the rituximab combination therapy.
Gerhard Held, Michael Pfreundschuh
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