Results 321 to 330 of about 3,641,641 (357)
Some of the next articles are maybe not open access.
The chilling origin of germinal centers
Science Immunology, 2023Germinal center–like structures have been identified in ectothermic vertebrates, establishing germinal centers as a universal component of humoral immunity (see related Research Article by Shibasaki et al. )
openaire +4 more sources
Immunosenescence and germinal center reaction
Immunological Reviews, 1997Summary: Dysfunction of the immune system in aged individuals includes at least two important factors: accumulation of immunocytes with reduced function and accumulation of lymphocyte clones with self‐reactive potential. Coincidently, there is a profound reduction of the germinal center reaction in the aged.
Biao Zheng +3 more
openaire +3 more sources
Regulating the germinal center
Science, 2017Immune Regulation Unregulated production of antibodies may contribute to the development of autoimmunity. In humans and mice, follicular regulatory T (Tfr) cells are thought to limit the germinal center reaction and reduce antibody production within B cell follicles. Yet how Tfr cells control the germinal center reaction is unclear. Ritvo et al.
openaire +2 more sources
To ‘B’ or not to ‘B’ a germinal center?
Immunology Today, 1997Abstract Under certain pathological conditions, germinal centers (GCs) form in many atypical sites, such as the stomach, lung and synovial joints. Thus, understanding the cellular and molecular interactions leading to a GC response is relevant not only for protective immunity but also for possible therapeutic strategies.
Marie Kosco-Vilbois +3 more
openaire +3 more sources
Plasma cell differentiation during the germinal center reaction
Immunological Reviews, 2019Germinal centers (GCs) are formed in secondary lymphoid tissues upon immunization with T‐dependent antigens. In GCs, somatic hypermutation generates B cells with increased antibody affinity and these high‐affinity B cells preferentially differentiate ...
W. Ise, T. Kurosaki
semanticscholar +1 more source
How to Simulate a Germinal Center
2017Germinal centers host a mini-evolutionary environment where B cells can mutate their receptor and be selected depending on its affinity to target antigens in a process called affinity maturation. Starting from founder cells with a weak B cell receptor affinity, germinal centers release output cells as antibody-secreting cells or memory cells with a ...
Sebastian Binder +3 more
openaire +3 more sources
Arthritis & Rheumatology, 2018
To determine risk factors for primary Sjögren's syndrome (SS)–associated lymphoma in a multicenter cohort of patients, with analysis of the predictive power of previously reported risk factors, including the presence of ectopic germinal center (GC)–like ...
D. Sène +8 more
semanticscholar +1 more source
To determine risk factors for primary Sjögren's syndrome (SS)–associated lymphoma in a multicenter cohort of patients, with analysis of the predictive power of previously reported risk factors, including the presence of ectopic germinal center (GC)–like ...
D. Sène +8 more
semanticscholar +1 more source
The physiology of germinal centers.
Critical reviews in immunology, 1996GCs contain Ag-induced rapidly proliferating B cell blasts called centroblasts and centrocytes and are located in primary follicles of peripheral lymphoid tissue. Their peak development is at 7 to 10 d after Ag. The generation of memory B cells occurs in GCs, accompanied by frequent Ig isotype switching, Ig gene V region somatic hypermutation, and/or ...
Tsiagbe VK +2 more
openaire +2 more sources
Germinal centers: form and function
Current Opinion in Immunology, 1998Our understanding of the formation of germinal centers has advanced considerably during the past year. Highlights include the elucidation of the role of cytokines and chemokines in splenic organization and lymphocyte migration and their roles in germinal center development.
openaire +3 more sources
Germinal centers in the human thymus
Zeitschrift f�r Zellforschung und Mikroskopische Anatomie, 1963This study reports the normal thymus of a 3 year old girl in which four germinal centers have been found in different lobules. They are located in the medulla, three of them in the cortico-medullary junction. Reticular cells, medium-sized and occasionally large lymphocytes, reticular macrophages and a large number of immature and mature thymocytes ...
openaire +3 more sources