Results 1 to 10 of about 340,349 (250)
WormBook, 2006 The DNA in eukaryotes is wrapped around a histone octamer core, together comprising the main subunit of chromatin, the nucleosome. Modifications of the nucleosomal histones in the genome correlate with the ability or inability of chromatin to form higher order structures, that in turn influence gene activity.
Christine E, Schaner, William G, Kelly
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Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways
Communications Biology, 2023 Reproduction is highly dependent on environmental and physiological factors including nutrition, mating stimuli and microbes. Among these factors, microbes facilitate vital functions for host animals such as nutritional intake, metabolic regulation, and ...
Ritsuko Suyama +3 more
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Trade-off between somatic and germline repair in a vertebrate supports the "expensive germ line" hypothesis [PDF]
, 2020 The disposable soma theory is a central tenet of the biology of aging where germline immortality comes at the cost of an aging soma [T. B. L. Kirkwood, Nature 270, 301–304 (1977); T. B. L. Kirkwood, Proc. R. Soc. Lond. B Biol. Sci. 205, 531–546 (1979); T.
Bublys, Kasparas +4 more
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Cell & Bioscience, 2022 Background Cadherins play a pivotal role in facilitating intercellular interactions between spermatogonial progenitor cells (SPCs) and their surrounding microenvironment.
Weixiang Song +8 more
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Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. [PDF]
, 2020 The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities of unexpected germline recombination in distinct Cre driver lines ...
Abumaria, Nashat +55 more
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Cell & Bioscience, 2023 Background The scarcity of pluripotent stem cells poses a major challenge to the clinical application, given ethical and biosafety considerations. While germline stem cells commit to gamete differentiation throughout life, studies demonstrated the ...
Rui Wei +10 more
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Cold Spring Harbor Perspectives in Biology, 2011 Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis, whereas differentiation at the expense of self-renewal can cause germ cell depletion and infertility.
Spradling, Allan +3 more
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Progress in germline stem cell transplantation in mammals and the potential usage
Reproductive Biology and Endocrinology, 2022 Germline stem cells (GSCs) are germ cells with the capacities of self-renewal and differentiation into functional gametes, and are able to migrate to their niche and reconstitute the fertility of recipients after transplantation.
Wen Zhang +4 more
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Imaging plant germline differentiation within Arabidopsis flowers by light sheet microscopy [PDF]
, 2020 In higher plants, germline differentiation occurs during a relatively short period within developing flowers. Understanding of the mechanisms that govern germline differentiation lags behind other plant developmental processes.
Bainar, Petr +8 more
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Germline‐targeting immunogens [PDF]
Immunological Reviews, 2017 SummaryIn 2009, Dimitrov's group reported that the inferred germline (iGL) forms of several HIV‐1 broadly neutralizing antibodies (bNAbs) did not display measurable binding to a recombinant gp140 Env protein (derived from the dual‐tropic 89.6 virus), which was efficiently recognized by the mature (somatically mutated) antibodies.
Leonidas, Stamatatos +2 more
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