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Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways
Communications Biology, 2023 Reproduction is highly dependent on environmental and physiological factors including nutrition, mating stimuli and microbes. Among these factors, microbes facilitate vital functions for host animals such as nutritional intake, metabolic regulation, and ...
Ritsuko Suyama +3 more
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Cell & Bioscience, 2022 Background Cadherins play a pivotal role in facilitating intercellular interactions between spermatogonial progenitor cells (SPCs) and their surrounding microenvironment.
Weixiang Song +8 more
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Cell & Bioscience, 2023 Background The scarcity of pluripotent stem cells poses a major challenge to the clinical application, given ethical and biosafety considerations. While germline stem cells commit to gamete differentiation throughout life, studies demonstrated the ...
Rui Wei +10 more
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Progress in germline stem cell transplantation in mammals and the potential usage
Reproductive Biology and Endocrinology, 2022 Germline stem cells (GSCs) are germ cells with the capacities of self-renewal and differentiation into functional gametes, and are able to migrate to their niche and reconstitute the fertility of recipients after transplantation.
Wen Zhang +4 more
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Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse
eLife, 2023 The development of tools to manipulate the mouse genome, including knockout and transgenic technology, has revolutionized our ability to explore gene function in mammals. Moreover, for genes that are expressed in multiple tissues or at multiple stages of
Vera Rinaldi +8 more
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Maternal transmission of mitochondrial diseases [PDF]
Genetics and Molecular Biology, 2020 Given the major role of the mitochondrion in cellular homeostasis, dysfunctions of this organelle may lead to several common diseases in humans. Among these, maternal diseases linked to mitochondrial DNA (mtDNA) mutations are of special interest due to ...
Marcos R. Chiaratti +6 more
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The clinical relevance of broad mutational screening of myeloproliferative neoplasms at diagnosis
Frontiers in Oncology, 2023 IntroductionMyeloproliferative neoplasm (MPN) is a heterogenous group of hematological malignancies including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF).
Helna Pettersson +8 more
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Does Shoot Apical Meristem Function as the Germline in Safeguarding Against Excess of Mutations?
Frontiers in Plant Science, 2021 A genetic continuity of living organisms relies on the germline which is a specialized cell lineage producing gametes. Essential in the germline functioning is the protection of genetic information that is subjected to spontaneous mutations.
Agata Burian
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Aging Negatively Impacts DNA Repair and Bivalent Formation in the C. elegans Germ Line
Frontiers in Cell and Developmental Biology, 2021 Defects in crossover (CO) formation during meiosis are a leading cause of birth defects, embryonic lethality, and infertility. In a wide range of species, maternal aging increases aneuploidy and decreases oocyte quality. In C.
Marilina Raices +4 more
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Androgen promotes differentiation of PLZF+ spermatogonia pool via indirect regulatory pattern
Cell Communication and Signaling, 2019 Background Androgen plays a pivotal role in spermatogenesis, accompanying a question how androgen acts on germ cells in testis since germ cells lack of androgen receptors (AR).
Jingjing Wang +10 more
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