Results 11 to 20 of about 340,349 (250)
Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse
eLife, 2023 The development of tools to manipulate the mouse genome, including knockout and transgenic technology, has revolutionized our ability to explore gene function in mammals. Moreover, for genes that are expressed in multiple tissues or at multiple stages of
Vera Rinaldi +8 more
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Porcine germline genome engineering [PDF]
Proceedings of the National Academy of Sciences, 2021 Germline editing, the process by which the genome of an individual is edited in such a way that the change is heritable, has been applied to a wide variety of animals [D. A. Sorrell, A. F. Kolb, Biotechnol. Adv. 23, 431–469 (2005); D. Baltimore et al., Science 348, 36–38 (2015)].
Luhan Yang +6 more
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Genes & Development, 2016 Nucleotides are required in order to replicate DNA in the developing germline. Here, Chi and colleagues (pp. 307–320) have usedCaernohabditis elegansto identify a GLP-1-dependent checkpoint that senses food (bacterially)-supplied nucleotide levels, arresting reproductive development in the absence of sufficient nucleotide supplies.
Shi, Cheng, Murphy, Coleen T.
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Fly, 2023 Valosin-containing protein (VCP) is a versatile and ubiquitously expressed AAA+ ATPase that regulates multiple stages of Drosophila spermatogenesis. While VCP has documented roles in mitotic spermatogonia and meiotic spermatocytes, it is also highly ...
Tyler J. Butsch +2 more
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Maternal transmission of mitochondrial diseases [PDF]
Genetics and Molecular Biology, 2020 Given the major role of the mitochondrion in cellular homeostasis, dysfunctions of this organelle may lead to several common diseases in humans. Among these, maternal diseases linked to mitochondrial DNA (mtDNA) mutations are of special interest due to ...
Marcos R. Chiaratti +6 more
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The clinical relevance of broad mutational screening of myeloproliferative neoplasms at diagnosis
Frontiers in Oncology, 2023 IntroductionMyeloproliferative neoplasm (MPN) is a heterogenous group of hematological malignancies including polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF).
Helna Pettersson +8 more
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WormBook, 2006 The completion of the C. elegans genome sequence permits the comprehensive examination of the expression and function of genes. Annotation of virtually every encoded gene in the genome allows systematic analysis of those genes using high-throughput assays, such as microarrays and RNAi.
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Androgen promotes differentiation of PLZF+ spermatogonia pool via indirect regulatory pattern
Cell Communication and Signaling, 2019 Background Androgen plays a pivotal role in spermatogenesis, accompanying a question how androgen acts on germ cells in testis since germ cells lack of androgen receptors (AR).
Jingjing Wang +10 more
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Does Shoot Apical Meristem Function as the Germline in Safeguarding Against Excess of Mutations?
Frontiers in Plant Science, 2021 A genetic continuity of living organisms relies on the germline which is a specialized cell lineage producing gametes. Essential in the germline functioning is the protection of genetic information that is subjected to spontaneous mutations.
Agata Burian
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Aging Negatively Impacts DNA Repair and Bivalent Formation in the C. elegans Germ Line
Frontiers in Cell and Developmental Biology, 2021 Defects in crossover (CO) formation during meiosis are a leading cause of birth defects, embryonic lethality, and infertility. In a wide range of species, maternal aging increases aneuploidy and decreases oocyte quality. In C.
Marilina Raices +4 more
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