Results 101 to 110 of about 246,242 (358)

Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy

Advanced Science, EarlyView.
This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou, Jia‐Xin Kou, Kai Zheng, Zi‐Xuan Guo, Hong‐Wei Fan, Wen‐Lian Li, Lu‐Lu Chu, Jing‐Wen Yin, Li‐Jie Liu, Zhi‐Gao Xiang, Feng Hu, Kai Shu, Ling‐Qiang Zhu, Dan Liu   +13 more
wiley   +1 more source

Effects of secondary prevention on quality of life of old patients at local sanatorium of the War Veterans Rehabilitation Center

Терапевтический архив, 2004
Aim. To study efficacy of sanatorium treatment of aged patients with gastroenterological and locomotor diseases in the heriatric center. Material and methods. 100 patients were investigated for effects of sanatorium treatment on quality of life. Results.
V L Geller, A N Chukreev, В G Usoltsev, М V Alexandrov, G I Sevastiyanova, N V Gudkov, A V Bursikov   +6 more
doaj  

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

Fifth International Congress of Gerontology [PDF]

, 1959
J. Trueta, Cheila Marina de Lima, Wilfred Fine, T.N. Rudd, C.T. Andrews, B. Steinmann   +5 more
openalex   +1 more source

Glucose‐Responsive and Analgesic Gel for Diabetic Subcutaneous Abscess Treatment by Simultaneously Boosting Photodynamic Therapy and Relieving Hypoxia

Advanced Science, EarlyView.
The work constructs a glucose‐triggered gel for diabetic abscess treatment. The results demonstrate that the gel catalyzes glucose into oxygen, alleviates the hypoxia, and ensures sufficient ROS generation to combat pathogenic bacteria. Simultaneously, borneol within the gel can enhance the antibacterial activity of ROS and alleviate pain in patients ...
Bin Huang, Honglin An, Jianfeng Chu, Shiqi Ke, Jing Ke, Yiman Qiu, Jieping Zhang, Hanqi Zhu, Jiahui Lin, Minguang Yang, Dongliang Yang, Xuejiao Song, Weilin Liu   +12 more
wiley   +1 more source

The Effect of an Aging Suit on Young and Middle-Aged Adults’ Attitudes Toward Older Adults [PDF]

, 2018
Background: Ageism, a type of discrimination based on a person’s age, can lead to negative attitudes, intolerance, and judgment towards older adults. With the increase of older adults in society, understanding the correlates of negative attitudes becomes
Allen, Kelly
core   +2 more sources

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

Advanced Science, EarlyView.
The protein levels of deubiquitinating enzyme A (DUBA) are rapidly upregulated in microglia after activation of Toll‐like receptor 4 (TLR4). In turn, DUBA potentiates TLR4‐induced proinflammatory signal transduction in microglia by stabilizing interleukin‐1 receptor activated kinase 1 (IRAK1) through K48 deubiquitination.
Zhenhu Zhu, Zhongding Li, Kate Lykke Lambertsen, Zijun Cao, Meng Chen, Yanqi Xu, Bettina Hjelm Clausen, Keshuo Jin, Yiting Lu, Fuqi Mei, Xue Du, Kangmin Chen, Huiyuan Bai, Xian Su, Bincheng Zhou, Baohua Liu, Ran Li, Chaoqun Wang, Yuhua Li, Xiang Cai, Dirk Schlüter, Weihong Song, Xu Wang   +22 more
wiley   +1 more source

Gerontologia Ambiental: panorama de suas contribuições para a atuação do gerontólogo

Revista Brasileira de Geriatria e Gerontologia
O artigo traz algumas considerações a respeito do campo teórico da Gerontologia Ambiental, ao traçar um breve panorama dos temas clássicos de estudo e aplicação dos novos campos abertos pelas demandas do envelhecimento populacional e políticas públicas ...
Samila Sathler Tavares Batistoni
doaj   +1 more source

Ageing at home with the help of information and communication technologies

Acta Geographica Slovenica, 2012
Due to the ageing of the population, developed countries are facing increasing financial needs to provide suitable healthcare, social care and housing for the elderly.
Boštjan Kerbler
doaj   +1 more source

Raising the level of medical gerontology: Evaluation of the European Academy for Medicine of Ageing course [PDF]

, 2018
The two-year EAMA course was established in 1995 by the Group of European Professors in Medical Gerontology (GEPMG) with the aim of raising the global standard of medical gerontology in (chiefly) European junior faculties. To determine the impact of this
Michel, J-P
core