Results 101 to 110 of about 289,899 (373)

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

open access: yesAdvanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng   +15 more
wiley   +1 more source

The individualized service plan as a clinical integration tool: qualitative analysis in the Quebec PRISMA experiment

open access: yesInternational Journal of Integrated Care, 2007
Introduction: One aspect of clinical integration involves case managers' tools and particularly the individualized service plan. Methods: We examined individualized service plan content and use in the PRISMA experiment.
Dominique Somme   +4 more
doaj   +1 more source

Senescence can play an essential role in modelling and estimation of vector based epidemiological indicators: demographical approach [PDF]

open access: yes
In the paper basic epidemiological indicators, produced by an aging population of vectors, are calculated. In the study we follow two lines: calculations for demographically structured population and individual life-history approach.
Anatoli I. Michalski   +5 more
core  

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

open access: yesAdvanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu   +9 more
wiley   +1 more source

Assessment of Willingness to Work with the Elderly and the Related Factors in Iranian Dental Students [PDF]

open access: yesSālmand
Objectives Due to the increase in the aged population and the need to improve their health and quality of life, the demand for social services and health care has increased. The present study e aims to investigate the willingness to work with the elderly
Malihe Saboor   +3 more
doaj  

Potential applications of virtual reality devices in older people. Narrative review

open access: yesJournal of Education, Health and Sport, 2019
Introduction Many of the non-pharmacological therapeutic interventions such as physical and mental exercises are focused on some of the dimensions of human cognition only.
Agnieszka Kujawska   +13 more
doaj   +1 more source

An investigation of factors associated with depression in older adults

open access: yes, 1989
As the population ages, there is a need for continued research into the etiology of geriatric depression and improved ways to detect individuals at risk for developing this disorder.
Mayhew, Katherine Mary
core   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang   +15 more
wiley   +1 more source

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