Results 91 to 100 of about 112,165 (302)

Offering Service-Learning in Gerontology Through a Coordinated Curriculum Model

, 2001
The purpose of this project was to develop a model for introducing service learning to an entire academic gerontology program curriculum. Brief historical backgrounds of service-learning and of gerontology are provided, along with a discussion of the ...
Murakami, Jacob
core  

Two‐Dimensional Conjugated Metal Organic Frameworks with Dual Metal Catalytic Active Sites Enhance POD Activity for Antibacterial Treatment

Advanced Science, EarlyView.
A new class of Cu, Ni bimetallic 2D cMOF (CuNi‐HHTP 2D cMOF) featuring dual catalytic sites and high delocalized electronic structure for boosting POD performance. The CuNi‐HHTP 2D‐cMOF enhances the conversion kinetics of H2O2 to ROS, which subsequently enhances antibacterial activity and accelerates the healing of oral ulcers, with macroscopic wound ...
Yixuan Lu, Qinqin Li, Yumin Chen, Shihan Zhang, Shuai Ding, Yanpei Wang, Youxing Liu, Yaru Guo, Xuliang Deng, Shaojun Guo   +9 more
wiley   +1 more source

Understanding older people's voice interactions with smart voice assistants: a new modified rule-based natural language processing model with human input

Frontiers in Digital Health
The COVID-19 pandemic has expedited the integration of Smart Voice Assistants (SVA) among older people. The qualitative data derived from user commands on SVA is pivotal for elucidating the engagement patterns of older individuals with such systems ...
Zhengxu Yan, Victoria Dube, Judith Heselton, Kate Johnson, Changmin Yan, Valerie Jones, Julie Blaskewicz Boron, Marcia Shade   +7 more
doaj   +1 more source

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Implementation of the gerontology area of the Inter - University Network for Healthy Aging of Latin America and the Caribbean (RIES-LAC)

The Decade of Healthy Aging (2021-2030) initiative fosters international action and offers an opportunity for different society stakeholders to implement measures that improve the quality of life of older adults and their environments.
Chavarro Carvajal, Diego, Lima Alberton, Cristine, Pizarro Mena, Rafael, Cuadros, Robinson, Tirro , Victoria, Chavarro-Carvajal,Diego, Pizarro-Mena,Rafael, López , María Fernanda, Baracaldo-Campo,Hendrik Adrián, Cuadros,Robinson, Maya-Rivero, Annika, López,María Fernanda, Maya-Rivero,Annika, Alberton,Cristine Lima, Wachholz, Patrick Alexander, Baracaldo Campo, Hendrik Adrián, Palomo,Iván, Tirro,Victoria, Palomo, Iván, Wachholz,Patrick Alexander   +19 more
core   +1 more source

A Personalized Haplotype‐Resolved Near‐Gapless Genome Framework for Somatic Variant Discovery in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A patient‐specific, haplotype‐resolved genome framework improves detection and interpretation of somatic variants in hepatocellular carcinoma. Using multi‐platform sequencing, the personalized assembly resolves complex regions including centromeres and MHC/HLA loci, enhances structural variant discovery, and links regulatory alterations to allele ...
Jiazheng Lin, Yao Xiao, Shuangzi Luo, Yifan Li, Wenfei Zhang, Xiaoyu Zhang, Xinyi Wang, Di Wu, Jieru Hong, Yongkun Luan, Xun Huang, Yixiu Wang, Ningbo Wu, Xiaoxiao Hu, Fei Zhao, Wei Li, Xiao Luo, Bi Shi   +17 more
wiley   +1 more source

A calling to compassionate care: the need for gerontology education in the seminary

, 2011
An understanding of all aspects of aging is crucial for those who work with elders. Parish priests minister to elder parishioners on a regular basis.
Diane Lynn Walsh
core  

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Professional Response: Intimate Partner Violence & Rural Older Women

, 2010
This brochure provides information for community professionals on how to identify and support victims of intimate partner violence.This project was supported by an academic-community partnership award # R03HD059478 from the Eunice Kennedy Shriver NICHD ...
Center for Gerontology
core