Results 71 to 80 of about 112,165 (302)
Advanced Science, EarlyView.Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang +3 more
wiley +1 more source
Advanced Science, EarlyView.Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang +27 more
wiley +1 more source
FEATURES AND PROFILE OF ENROLLED IN ELDERLY FAMILY HEALTH PROGRAM [PDF]
Revista Gestão & Saúde, 2011 This essay aims to provide brief information about aspects of aging on their influence on functional capacity, not only on the intrinsic factors, such as physiological and disease, but as to extrinsic factors such as socioeconomic and demographic ...
Adriano Drummond
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Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration
Advanced Science, EarlyView.This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya +10 more
wiley +1 more source
The Gerontology Institute: The First Years, 1984-1987 [PDF]
, 1989 During the first years of its existence, the Gerontology Institute has worked with older people to convert retirement years into opportunities for continuous growth and learning, while simultaneously seeking to re-examine social, political, and ...
Gerontology Institute, University of Massachusetts Boston
core +1 more source
Advanced Science, EarlyView.Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu +7 more
wiley +1 more source
Österreichische Zeitschrift für Geschichtswissenschaften, 2011 Social policies of Nazi Germany aimed directly at cutting expenses for pensions and other social security benefits for old people. In order to reduce social costs, the age of retirement was supposed to be increased through various policies.
Benjamin Möckel
doaj +1 more source
Advanced Science, EarlyView.A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li +15 more
wiley +1 more source
Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy
Advanced Science, EarlyView.A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li +11 more
wiley +1 more source
Female gerontology in TV-advertising [PDF]
Социологический журнал, 2012 The paper backgrounds the necessity of theoretical advancing the female gerontology project. Two models of female gerontology problems interpretation are considered: the model of “mail dominance” and the model of “female narcissism”.
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