Results 71 to 80 of about 246,242 (358)

Is Gerontology in Crisis? [PDF]

The Gerontologist, 2015
A recently published Science article reported that efforts to reproduce findings from 100 studies published in three leading psychology journals concluded that more than 60% of the findings did not hold up when retested (Open Science Collation, 2015). While the Reproducibility Project found no evidence of fraud, it concluded that the evidence for most ...
Barbara J. Bowers, Judith G. Gonyea, Helen Q. Kivnick, Suzanne Meeks, Rachel Pruchno, John B. Williamson, Nicholas G. Castle   +6 more
openaire   +3 more sources

Discovery of Natural Compound α‐Hederin via Large‐Scale Screening as a Targeted JAK/STAT3 Inhibitor for Ovarian Cancer Therapy

Advanced Science, EarlyView.
This study identifies α‐Hederin as a potent dual JAK1/JAK2 inhibitor that blocks STAT3 activation in ovarian cancer. By disrupting STAT3‐driven transcriptional programs, α‐Hederin suppresses tumor proliferation, invasion, and EMT, while enhancing cisplatin efficacy and overcoming chemoresistance.
Jiayu Wang, Pengzhan He, Cheng Liu, Xin Chen, Yilin Tan, Rui Qu, Yan Zhang, Zhou Li, Tailang Yin, Zhinang Yin   +9 more
wiley   +1 more source

Inhibition of UBE2C Promotes Parkin‐Mediated K63‐Linked Ubiquitination of TOP2A to Induce Senescence and Increase Sensitivity of Doxorubicin in Breast Cancer

Advanced Science, EarlyView.
In the study, UBE2C was found to be significantly overexpressed in breast cancer and transcriptionally regulated by FOXM1. Inhibition of UBE2C suppressed proliferation, induced senescence, and sensitized breast cancer cells to doxorubicin. Mechanistically, UBE2C inhibition promoted Parkin‐mediated K63‐linked ubiquitination of TOP2A.
Yihui Yang, Wan Li, Hong Yang, Fang Xu, Sen Zhang, Wanxin Cao, Xiaoxue Li, Xu Zhang, Xiangyin Chi, Hongquan Wang, Guanhua Du, Yumin Wang, Jinhua Wang   +12 more
wiley   +1 more source

Developing inclusive later life learning environments: insights from intersectional analysis of ageing and lesbian, gay, transgendered and bisexual identities [PDF]

, 2018
To date there has been minimal empirical inquiry on what may constitute inclusive learning environments for older (50+ years) lesbian, gay, bisexual and transgendered (LGBT) adults.
McAllister, Christopher
core   +4 more sources

BrainFusion: a Low‐Code, Reproducible, and Deployable Software Framework for Multimodal Brain‒Computer Interface and Brain‒Body Interaction Research

Advanced Science, EarlyView.
BrainFusion is a low‐code software framework for multimodal brain–computer interface (BCI)​​ and brain–body interaction research. It supports ​electroencephalography (EEG)​, functional near‐infrared spectroscopy (fNIRS), electromyography (EMG)​, and electrocardiography (ECG)​​ integration with standardized preprocessing, feature fusion, and model ...
Wenhao Li, Chenyang Gao, Zhaobo Li, Yunheng Diao, Jiaxin Li, Jiayi Zhou, Jing Zhou, Ying Peng, Guanchu Chen, Xuecheng Wu, Kai Wu   +10 more
wiley   +1 more source

DNA hydroxymethylation levels are altered in blood cells from Down syndrome persons enrolled in the MARK-AGE project [PDF]

, 2017
Down syndrome (DS) is caused by the presence of part or an entire extra copy of chromosome 21, a phenomenon that can cause a wide spectrum of clinically defined phenotypes of the disease. Most of the clinical signs of DS are typical of the ageing process
BACALINI, MARIA GIULIA, Breusing, Nicolle, Bürkle, Alexander, CAIAFA, Paola, CALABRESE, ROBERTA, Capri, Miriam, CICCARONE, FABIO, Franceschi, Claudio, Grune, Tilman, GUASTAFIERRO, Tiziana, Malavolta, Marco, Moreno villanueva, María, REALE, Anna, VALENTINI, ELISABETTA, ZAMPIERI, Michele   +14 more
core   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Cognitive and Integrated Intervention Therapy in the Geriatric Population and its Benefits on Daily Living Activities and Quality of Life: A Narrative Review [PDF]

Journal of Clinical and Diagnostic Research
Physiotherapists have expanded their scope into a wide array of fields, including various cognitive-based therapies and mixed integrated intervention therapies. Multiple databases were used in present literature review, including Medline, PubMed, Scopus,
Mantu Paul, Binod Chandra Sarma, Niharika Dihidar   +2 more
doaj   +1 more source

Integrative Omics Reveals Glutamine Catabolism‐Driven Apoptotic Suppression in Monocytes upon Mechanical Unloading

Advanced Science, EarlyView.
This research integrated multi‐omics analysis of bone tissue from HLU and control mice revealed that mechanical unloading suppresses intrinsic apoptosis and augments glutamine (Gln) catabolism in osteoclast lineage cells. The findings highlight pivotal roles for SLC1A5‐mediated Gln metabolism and XIAP/Diablo axis‐mediated apoptosis suppression.
Yi Ding, Fan Tong, Mingqiu Liu, Pin Yang, Jing Zeng, Yinghua Wei, Chunlin Li, Dong Li, Cheng Chang, Yangjun Zhang, Shaoqiong Yi, Fan Hu, Wenjie Shu, Lingqiang Zhang, Chun‐Ping Cui   +14 more
wiley   +1 more source

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source