Results 1 to 10 of about 5,729 (120)

Associations of green and blue space exposure in pregnancy with epigenetic gestational age acceleration [PDF]

Epigenetics, 2023
Early life is seen as a particularly sensitive period for environmental exposures. Natural space exposure during pregnancy has been associated with offspring health.
Irene Marques, Susana Santos, Giulietta S. Monasso, Serena Fossati, Martine Vrijheid, Mark Nieuwenhuijsen, Vincent W. V. Jaddoe, Janine F. Felix   +7 more
doaj   +6 more sources

Epigenetic gestational age acceleration: a prospective cohort study investigating associations with familial, sociodemographic and birth characteristics [PDF]

Clinical Epigenetics, 2018
Background Gestational age at delivery is associated with health and social outcomes. Recently, cord blood DNA methylation data has been used to predict gestational age.
Jasmine N. Khouja, Andrew J. Simpkin, Linda M. O’Keeffe, Kaitlin H. Wade, Lotte C. Houtepen, Caroline L. Relton, Matthew Suderman, Laura D. Howe   +7 more
doaj   +7 more sources

Prenatal and birth associations of epigenetic gestational age acceleration in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort [PDF]

Epigenetics, 2022
Gestational age (GA) is an important determinant of child health and disease risk. Two epigenetic GA clocks have been developed using DNA methylation (DNAm) patterns in cord blood.
Saher Daredia, Karen Huen, Lars Van Der Laan, Philip A. Collender, Jamaji C. Nwanaji-Enwerem, Kim Harley, Julianna Deardorff, Brenda Eskenazi, Nina Holland, Andres Cardenas   +9 more
doaj   +6 more sources

Gestational age acceleration is associated with epigenetic biomarkers of prenatal physiologic stress exposure. [PDF]

Clin Epigenetics, 2022
Abstract Background Physiological maternal stress response, such as imbalance in the glucocorticoid pathway and immune system seems to be mediated by DNA methylation (DNAm) and might translate intrauterine stress exposures into phenotypic changes in a sex-specific manner.
Euclydes V, Gomes C, Gouveia G, Gastaldi VD, Feltrin AS, Camilo C, Vieira RP, Felipe-Silva A, Grisi S, Fink G, Brentani A, Brentani H.   +11 more
europepmc   +5 more sources

Cross-Cohort Mixture Analysis: A Data Integration Approach With Applications on Gestational Age and DNA-Methylation-Derived Gestational Age Acceleration Metrics. [PDF]

Biom J
ABSTRACT Data integration of multiple studies can provide enhanced exposure contrast and statistical power to examine associations between environmental exposure mixtures and health outcomes. Extant research has combined populations and identified an overall mixture–outcome association, without accounting for differences across ...
Colicino E, Ascari R, Saddiki H, Merced-Nieves F, Foppa Pedretti N, Huddleston K, Wright RO, Wright RJ, Program Collaborators for Environmental Influences on Child Health Outcomes.   +8 more
europepmc   +4 more sources

Immune pathways and prenatal/perinatal environmental exposures contribute to epigenetic gestational age prediction and acceleration [PDF]

Epigenetics
DNA methylation (DNAm), capturing chronological gestational age (GA) and epigenetic gestational age acceleration (EGAA), can be modified by environmental exposures. The Asthma&Allergy array is a new DNAm array developed with content focused on asthma and
Amy A. Eapen, Ian M. Loveless, Mingming Pan, Xiaoyu Liang, Audrey Urquhart, Jennifer K. Straughen, Andrea E. Cassidy-Bushrow, Alexandra R. Sitarik, Neil Simmerman, Emma Thompson, Leah Kottyan, Carole Ober, Christine C. Johnson, Edward Zoratti, Albert M. Levin   +14 more
doaj   +2 more sources

Epigenetic Age Acceleration in Mothers and Offspring 4–10 Years after a Pregnancy Complicated by Gestational Diabetes and Obesity

Metabolites, 2022
A known association exists between exposure to gestational diabetes mellitus (GDM) and epigenetic age acceleration (EAA) in GDM-exposed offspring compared to those without GDM exposure.
Nita Kanney, Amit Patki, Paula Chandler-Laney, W. Timothy Garvey, Bertha A. Hidalgo   +4 more
doaj   +3 more sources

Maternal Vitamin D Deficiency Is a Risk Factor for Infants' Epigenetic Gestational Age Acceleration at Birth in Japan: A Cohort Study. [PDF]

Nutrients
Background/Objectives: The DNA methylation of neonatal cord blood can be used to accurately estimate gestational age. This is known as epigenetic gestational age. The greater the difference between epigenetic and chronological gestational age, the greater the association with an inappropriate perinatal fetal environment and development.
Kawai T, Jwa SC, Ogawa K, Tanaka H, Aoto S, Kamura H, Morisaki N, Fujiwara T, Hata K.   +8 more
europepmc   +3 more sources

Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics [PDF]

iScience
Summary: Epigenetic gestational age acceleration has been implicated in obstetric syndromes including preeclampsia, yet robust conclusions require accurate and unbiased epigenetic age models.
Gaurav Bhatti, Herdiantri Sufriyana, Roberto Romero, Tushar Patel, Fasil Tekola-Ayele, Ibrahim Alsaggaf, Nardhy Gomez-Lopez, Emily C.Y. Su, Bogdan Done, Steve Hoffmann, Alena van Bömmel, Cen Wan, Jake Albrecht, Charles Novak, Tinnakorn Chaiworapongsa, Marina Sirota, Nima Aghaeepour, Gustavo Stolovitzky, David R. Bryant, Adi L. Tarca   +19 more
doaj   +2 more sources

Analysis of prenatal medication use and placental epigenetic gestational age in extremely low gestational age newborns (ELGANs) highlight relationships to aspirin use during pregnancy [PDF]

Clinical Epigenetics
Background Several maternal exposures such as acetaminophen during pregnancy have been previously associated with altered placental CpG methylation. Epigenetic gestational age measures biological aging using DNA methylation from gestational tissues such ...
Katelyn K. Huff, Catherine M. Bulka, Jeliyah Clark, Kyle R. Roell, T. Michael O’Shea, Rebecca C. Fry   +5 more
doaj   +2 more sources