The application of hysteroscopy in gestational trophoblastic disease
Objective: The purpose of this article is to describe the application of hysteroscopy in different cases of gestational trophoblastic disease. Materials and methods: Three patients who presented with gestational trophoblastic disease were managed with ...
Angelica Anne A. Chua +2 more
doaj +1 more source
Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley +1 more source
Leptomeningeal spread of gestational trophoblastic neoplasia in a 19-year old woman
Gestational trophoblastic neoplasia (GTN) with brain metastasis is usually seen in patients with advanced disease. Ten percent of metastatic gestational trophoblastic disease involves the brain and spinal cord, most often manifesting as an intracerebral ...
Nnamdi I. Gwacham +3 more
doaj +1 more source
Uncovering the role of genetic polymorphisms in cervical insufficiency
Pathways and genes implicated in CI pathogenesis. Abstract Cervical insufficiency (CI) is characterized by spontaneous dilation of the cervix in the absence of painful uterine contractions in the mid‐trimester, leading to premature delivery. It is responsible for up to 20% of second trimester pregnancy losses, mostly <24 weeks.
Kallirhoe Kalinderi +3 more
wiley +1 more source
A review on management of gestational trophoblastic neoplasia
Background: The rare presence of malignant cancerous cells afar any type of pregnancy is known as gestational trophoblastic neoplasia (GTN). GTN are benign lesions which mostly happen due to the activity of extravillous trophoblast cells and the ...
Seyedeh Reyhaneh Yousefi Sharami +1 more
doaj +1 more source
Hematologic markers and machine learning in predicting placenta accreta: A case–control study
Abstract Objective This study aims to enhance antenatal detection of placenta accreta spectrum (PAS) and predict severe hemorrhage at delivery using machine learning by evaluating the association between antenatal hematologic index trends across trimesters, imaging markers, and patient history.
Michael D. Jochum +11 more
wiley +1 more source
Understanding pre‐eclampsia and fetal growth restriction at high altitude: A narrative review
Abstract Pre‐eclampsia (PE) and fetal growth restriction (FGR) are among the leading causes of maternal and perinatal morbidity and mortality worldwide. Both conditions are more frequent and severe at high altitudes due to physiological changes in oxygen availability and vascular adaptation.
Víctor S. Rangel +6 more
wiley +1 more source
Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu +6 more
wiley +1 more source
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang +6 more
wiley +1 more source
Sonographic Predictors and Long‐Term Reproductive Outcomes in Recurrent Cesarean Scar Pregnancy
Objectives To explore the ultrasound findings, treatment strategies, and reproductive outcomes in patients with recurrent cesarean scar pregnancy (CSP), providing evidence for clinical management. Methods We identified 1371 confirmed CSP from 1517 initially screened cases (2012–2022) through blinded image review. From 159 subsequent live births in this
Jianan Shi +6 more
wiley +1 more source

