Results 81 to 90 of about 7,331 (186)

Placental mitochondrial metabolic adaptation maintains cellular energy balance in pregnancy complicated by gestational hypoxia

The Journal of Physiology, EarlyView.
Abstract figure legend Placental mitochondrial adaptation to gestational hypoxia. Hypoxic pregnancy in sheep increases placental insulin like growth factor 2 (IGF2) signalling (1), which is associated with a shift in capacity away from β‐oxidation (2) and complex I‐mediated respiration (3), while maintaining total oxidative phosphorylation capacity (4).
Wen Tong, Beth J. Allison, Kirsty L. Brain, Olga V. Patey, Youguo Niu, Kimberley J. Botting, Sage G. Ford, Tess A. Garrud, Peter F. B. Wooding, Qiang Lyu, Lin Zhang, Jin Ma, Alice P. Sowton, Katie A. O'Brien, Tereza Cindrova‐Davies, Hong Wa Yung, Graham J. Burton, Andrew J. Murray, Dino A. Giussani   +18 more
wiley   +1 more source

Endothelial‐to‐mesenchymal transition in the fetoplacental macrovasculature and microvasculature in pregnancies complicated by gestational diabetes

The Journal of Physiology, EarlyView.
Abstract figure legend Transforming growth factor (TGF)‐β2 and interleukin (IL)‐1β induced morphological and molecular changes consistent with endothelial‐to‐mesenchymal transition (EndMT) in HUVECs isolated from both pregnancies complicated by gestational diabetes (GDM) and non‐GDM pregnancies.
Abigail R. Byford, Georgia Fakonti, Ziyu Shao, Sharanam Soni, Sophie L. Earle, Muath Bajarwan, Lara C. Morley, Beth Holder, Eleanor M. Scott, Karen Forbes   +9 more
wiley   +1 more source

High‐elevation adaptation and gestational hypoxia jointly shape vascular development in a rodent placenta

The Journal of Physiology, EarlyView.
Abstract figure legend We investigated how environmental hypoxia and genetic adaptation to high altitudes jointly impact the development of the placental exchange surface in ways that might protect fetal growth potential. We used wild‐derived, lab‐born North American deer mice (Peromyscus maniculatus) from low‐elevation and high‐elevation environments (
Kathryn Wilsterman, Zachary A. Cheviron, Jeffrey M. Good, Kai Gurnoe‐Brantley, Kylie E. Jewett, Katherine Kiel, Ashley M. Larson   +6 more
wiley   +1 more source

Placental iron utilisation in fetal growth restriction: alterations in mitochondrial haem synthesis and iron–sulphur cluster assembly pathways

The Journal of Physiology, EarlyView.
Abstract figure legend Altered iron handling and mitochondrial pathways in FGR placentas. Placental tissue from FGR pregnancies showed increased expression of iron importers, transferrin and divalent metal transporter 1, and decreased expression of the iron exporter ferroportin, suggesting that the FGR placenta is retaining iron to meet its own ...
Veronica B. Botha, Heather C. Murray, Siddharth Acharya, Kirsty G. Pringle, Roger Smith, Joshua J. Fisher   +5 more
wiley   +1 more source

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Platelet hyperreactivity and risk of ischemic placental disease: A prospective cohort study

Pregnancy, Volume 2, Issue 2, March 2026.
Abstract Introduction Platelet hyperreactivity is linked to inflammation and cardiovascular risk in nonpregnant populations, but its relationship to placentally mediated pregnancy outcomes is undefined. We prospectively evaluated platelet hyperreactivity in pregnancy and subsequent ischemic placental disease (IPD), and examined aspirin's (ASA) effect ...
Christina A. Penfield, Andre A. Robinson, Ariel Schaap, Elliot Luttrell‐Williams, Anais Hausvater, Yuhe Xia, Matthew Muller, Madison S. House, Valeryia Avtushka, Lila Murphy, Clarice G. Zhou, Justin S. Brandt, Gwendolyn P. Quinn, Ashley S. Roman, Dana R. Gossett, Jeffrey S. Berger   +15 more
wiley   +1 more source

Gestational Trophoblastic Disease with Hyperthyroidism and Severe Pre-eclampsia: Anesthetic Management

Siriraj Medical Journal, 2015
Gestational trophoblastic disease originates from abnormal proliferation of molar tissue and most of them are not complicated. However, life threatening complications such as hyperthyroidism and severe pre-eclampsia can occur.
Raviwon Atisook
doaj  

Twin Pregnancies—Emergency Cerclage in the Second Trimester and Delivery of Second Twins 110 and 123 Days Later

Reproductive, Female and Child Health, Volume 5, Issue 1, March 2026.
ABSTRACT Background: Since the 1980s, the global twinning rate has risen to about 1.6 million twin pairs annually due to the widespread use of IVF. Twin pregnancies carry a higher risk of complications compared to singleton pregnancies, with cervical insufficiency being a significant concern that can lead to preterm birth and adverse perinatal outcomes.
Iakovos Soussis, Efi Roboti, Andreas Bazeos, Sara Sousi, Neratzoula Sakka, Stavros Fotopoulos   +5 more
wiley   +1 more source

Anaesthetic Challenges in Molar Pregnancy

The Indian Anaesthetists' Forum, 2013
Gestational Trophoblastic Disease (GTD) is a spectrum of tumours with a wide range of biologic behaviour and potential for metastases, which were often fatal in the past.
Ghansham Biyani, Sadik Mohammed, Pradeep Bhatia   +2 more
doaj  

Amniotic Mesenchymal Stromal/Stem Cell–Derived Extracellular Vesicles for Equine Chronic Degenerative Endometritis Treatment

Veterinary Medicine and Science, Volume 12, Issue 2, March 2026.
Equine endometrium can develop progressive fibrotic and functional alterations, probably correlated with age and inflammatory insults that alter uterine microenvironment, creating hostile conditions for embryo implantation. Named chronic degenerative endometritis, this condition leads to reduced fertility in older mares. Extracellular vesicles secreted
Giulia Gaspari, Federico Funghi, Carlo Cantile, Francesco Camillo, Duccio Panzani, Saverio Maltinti, Diana Fanelli, Rebecca Moroni, Fausto Cremonesi, Paola Gagni, Anna Lange‐Consiglio   +10 more
wiley   +1 more source