Results 91 to 100 of about 127,947 (249)

Crosstalk Between CTSB+ Glioblastoma Cells and S100A10+ Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

Advanced Science, EarlyView.
In glioblastoma, M2‐polarized macrophages secrete IL‐6, which activates STAT3 signaling in tumor cells to upregulate CTSB. Tumor‐derived CTSB binds the C‐terminus of macrophage S100A10, reinforcing M2 polarization and further IL‐6 secretion, thereby establishing a feedforward IL‐6/STAT3/CTSB/S100A10 loop. This cascade drives tumor growth, invasion, and
Hao Zhang, Nan Zhang, Xisong Liang, Jie Wen, Ziyu Dai, Wantao Wu, Shuyu Li, Songshan Feng, Zaoqu Liu, Zhiwei Xia, Peng Luo, Quan Cheng   +11 more
wiley   +1 more source

Colocalization of GFAP (green) and mHtt (red).

, 2014
(A) A low magnification picture illustrates GFAP-ir astrocytes and mHtt deposits from the retinal wholemount of 12-week-old R6/2 mouse. Scale bar = 50 µm.
Kestutis Gurevicius (300762), Seppo Rönkkö (668698), Jooseppi Puranen (668697), Soile Nymark (668699), Giedrius Kalesnykas (482088), Outi Kontkanen (112459), Henri Leinonen (668696), Arto Lipponen (287437), Jukka Puoliväli (112439), Symantas Ragauskas (668695), Heikki Tanila (300765)   +10 more
core   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Immunocytochemical analyses of GFAP stained images.

, 2016
(A-D) GFAP-positive astrocyte cells derived from co-culturing of mESCs and PA6 cells. (E) GFAP expression quantified using fluorescent intensity measurements shows a continuous increase in the protein content.
Nathan Morris (2696935), Ramila Joshi (1521487), James Carlton Buchanan (3342467), Sailaja Paruchuri (446304), Hossein Tavana (1521490)   +4 more
core   +1 more source

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Fibroblasts can express glial fibrillary acidic protein (GFAP) in vivo.

, 2001
Neuropathologists use anti-glial fibrillary acidic protein (GFAP) antibodies as specific markers for glial cells, and neurobiologists use GFAP for targeting transgenes to glial cells.
Voigtländer, T, Mazal, P R, Budka, H, Maddalena, A S, Hainfellner, J A, Ströbel, T, Aguzzi, A; https://orcid.org/   +6 more
core   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Time-dependent associations of GFAP and interferon-α with cognitive and functional outcomes after ischemic stroke: a prospective cohort study [PDF]

Yang Liu, 马文静, Xiaoyan Qian, Shiliang Wu, Chengjie Yan, Fang Shen, Yaping Wu, Zhaoxi Ma, Yan Zhang   +8 more
openalex   +1 more source

Mean values of NFL, GFAP and BPF.

, 2015
The mean values of NFL, GFAP and BPF, stratified by age.* denotes that the numbers indicate range instead of IQRIQR = Interquartile rangeNFL = Neurofilament LightGFAP = Glial Fibrillary Acidic ProteinBPF = Brain Parenchymal Fraction.Mean values of NFL ...
Niklas Norgren (461419), Ann Dring (789461), Mattias Vågberg (789460), Henrik Zetterberg (144718), Thomas Lindqvist (789462), Richard Birgander (789463), Anders Svenningsson (392782)   +6 more
core   +1 more source

Targeting Hippocampal PTEN Suppresses Ferroptosis and Rescues Cognitive Decline in Alzheimer's Disease via Dual AKT/GSK3β/Nrf2 and AKT/STAT3 Axes

Advanced Science, EarlyView.
PTEN knockdown activates AKT phosphorylation, promoting Nrf2 nuclear translocation and STAT3 activation, which upregulates GPX4 and antioxidant enzymes HO‐1, SOD1, SOD2, and NQO1. These coordinated changes reduce lipid peroxidation and ROS, inhibit ferroptosis, and ultimately ameliorate cognitive impairment in APP/PS1 transgenic mice, highlighting a ...
Da‐Wei Wang, Meng‐Meng Liu, Yu‐Chen Zhao, Jia‐Yi Li, Wen Li, Xin Yu   +5 more
wiley   +1 more source