Results 61 to 70 of about 102,753 (263)

OBJECTIVE METHODS FOR DETERMINE THE SEVERITY AND PROGNOSIS OF PERINATAL HYPOXIC-ISCHEMIC CNS

Акушерство, гинекология и репродукция, 2016
Perinatal hypoxic-ischemic damage of the CNS is a major cause of mortality and neonatal incapacitating. The severity and prognosis is not always possible to accurately determine by clinical and tools methods of examination.
D. V. Blinov
doaj  

Pathomorphological brain changes due to coronavirus disease 2019 (COVID-19)

Patologìâ
Aim: To investigate the pathomorphological changes in the brains of individuals who died from complications of coronavirus disease (COVID-19) and to identify the neuropathological features associated with COVID-19. Materials and methods.
L. I. Volos, H. L. Stoliar
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Glial Cell Architecture Dynamics in Dentate Gyrus and CA4 Area of Wistar Rat Hippocampus Following 20-minute Occlusion of Common Carotid Arteries

Общая реаниматология, 2019
Aim. To study the distribution and spatial organization of dentate gyrus (DG) astrocytes and CA4 area of hippocampus of Wistar rats following 20-minute occlusion of common carotid arteries (OCCA) compared to sham-operated control animals.Material and ...
Anna V. Gorbunova, Dmitry B. Avdeev, Sergey S. Stepanov, Victor A. Akulinin, Alexander S. Stepanov, Anastasia Yu. Shoronova, Artem A. Samsonov   +6 more
doaj   +1 more source

The GFAP proteoform puzzle: How to advance GFAP as a fluid biomarker in neurological diseases

Journal of Neurochemistry
Abstract Glial fibrillary acidic protein (GFAP) is a well‐established biomarker of reactive astrogliosis in the central nervous system because of its elevated levels following brain injury and various neurological disorders.
Dea Gogishvili, Madison I. J. Honey, Inge M. W. Verberk, Lisa Vermunt, Elly M. Hol, Charlotte E. Teunissen, Sanne Abeln   +6 more
openaire   +4 more sources

Glial Fibrillary Acidic Protein (GFAP) in Oligodendrogliomas: A Reflection of Transient GFAP Expression by Immature Oligodendroglia [PDF]

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 1986
ABSTRACT:Fourteen pure oligodendrogliomas were studied by light- and electronmicroscopy and immunohistochemistry to examine glial fibrillary acidic protein (GFAP) positivity in the tumors. To compare the immunohistochemical staining patterns of neoplastic oligodendroglia and immature oligodendroglia, myelination glia in the white matter of eight normal
V, Jagadha, W C, Halliday, L E, Becker
openaire   +2 more sources

Mechanically Compliant, Precision‐Porous Brain Implants Reduce the Foreign Body Reaction and Guide Regeneration

Advanced Healthcare Materials, EarlyView.
This study explores how the brain responds to implants of different properties. Hydrogels with various mechanical properties and pore sizes were implanted in adult rat brains. It is observed that hydrogels with mechanical property closely matched to the brain and 40 µm pore size elicit a pro‐healing response from the brain by modulating the immune ...
Ian Dryg, Le Zhen, Rebecca Darrow, Savannah Lawton, Lars Crawford, Robert Robinson, Steve Perlmutter, James D. Bryers, Buddy D. Ratner   +8 more
wiley   +1 more source

The Use of Neuromarker NSE, S100-B, GFAP Proteins in the Diagnosis and Treatment of Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage

Неотложная медицинская помощь
The incidence of non-traumatic subarachnoid hemorrhage due to rupture of cerebral aneurysms and subsequent disability motivates the search for predictors of severe course and unfavorable outcome of the disease for early intensive treatment.
V. A. Lukyanchikov, M. A. Godkov, I. Yu. Gordeev, E. S. Vayman   +3 more
doaj   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source