Results 141 to 150 of about 120,747 (306)

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Colocalization of GFAP (green) and mHtt (red).

, 2014
(A) A low magnification picture illustrates GFAP-ir astrocytes and mHtt deposits from the retinal wholemount of 12-week-old R6/2 mouse. Scale bar = 50 µm.
Kestutis Gurevicius (300762), Seppo Rönkkö (668698), Jooseppi Puranen (668697), Soile Nymark (668699), Giedrius Kalesnykas (482088), Outi Kontkanen (112459), Henri Leinonen (668696), Arto Lipponen (287437), Jukka Puoliväli (112439), Symantas Ragauskas (668695), Heikki Tanila (300765)   +10 more
core   +1 more source

Stretchable Microelectrode Arrays with Microneedles for Reliable Electrophysiological Recording of Human Heart and Brain Organoids

Advanced Science, EarlyView.
A stretchable 3D microelectrode array with microneedles (3D MN‐sMEA) enables stable, minimally destructive electrophysiological monitoring of 3D organoids. The wafer‐level stud‐bump bonding process facilitates high‐fidelity recordings of heart and cerebral organoids.
Eunyoung Jang, Saewoon Shin, Seul‐Gi Lee, Kiup Kim, Yoojeong Kim, Jun Sun, Il‐Joo Cho, Joseph A. Gogos, Jong‐Chan Park, C‐Yoon Kim, Hyunjoo J. Lee   +10 more
wiley   +1 more source

Mean values of NFL, GFAP and BPF.

, 2015
The mean values of NFL, GFAP and BPF, stratified by age.* denotes that the numbers indicate range instead of IQRIQR = Interquartile rangeNFL = Neurofilament LightGFAP = Glial Fibrillary Acidic ProteinBPF = Brain Parenchymal Fraction.Mean values of NFL ...
Niklas Norgren (461419), Ann Dring (789461), Mattias Vågberg (789460), Henrik Zetterberg (144718), Thomas Lindqvist (789462), Richard Birgander (789463), Anders Svenningsson (392782)   +6 more
core   +1 more source

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source

Immunocytochemical analyses of GFAP stained images.

, 2016
(A-D) GFAP-positive astrocyte cells derived from co-culturing of mESCs and PA6 cells. (E) GFAP expression quantified using fluorescent intensity measurements shows a continuous increase in the protein content.
Nathan Morris (2696935), Ramila Joshi (1521487), James Carlton Buchanan (3342467), Sailaja Paruchuri (446304), Hossein Tavana (1521490)   +4 more
core   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

VGB treatment decreased the number of GFAP positive cells in hippocampus of Tsc1^GFAPCKO mice.

, 2013
(A) Vehicle-treated Tsc1GFAPCKO mice (KO + Veh) displayed a diffuse increase in GFAP-positive cells in neocortex and hippocampus compared with the vehicle-treated control mice (Cont + Veh). VGB treatment partially prevented this increase in GFAP-positive
Michael Wong (204064), Nicholas R. Rensing (379640), Sharon S. McDaniel (379639), Bo Zhang (6559)   +3 more
core   +1 more source

Microplastics‐Induced Gut Microbiota Dysbiosis Accelerates Alzheimer's‐Like Pathology and Cognitive Decline via the Gut–Brain Axis

Advanced Science, EarlyView.
Microplastics (MPs) breach the gut‐brain axis by triggering taurine‐depleting microbiota dysbiosis that accelerates Alzheimer‐like pathology in 5XFAD mice. Taurine supplementation normalizes autophagy, microglial quiescence, and cognition, and plasma taurine inversely tracks cognitive decline in ADNI participants, revealing a readily translatable ...
Zifeng Wu, Jiarong Yang, Miaoxuan Zhang, Yi Li, Zhuling Tu, Ji Wang, Jin‐Tai Yu, Kun Guo, Rongcan Luo   +8 more
wiley   +1 more source

Fibroblasts can express glial fibrillary acidic protein (GFAP) in vivo.

, 2001
Neuropathologists use anti-glial fibrillary acidic protein (GFAP) antibodies as specific markers for glial cells, and neurobiologists use GFAP for targeting transgenes to glial cells.
Voigtländer, T, Mazal, P R, Budka, H, Maddalena, A S, Hainfellner, J A, Ströbel, T, Aguzzi, A; https://orcid.org/   +6 more
core   +1 more source