Results 151 to 160 of about 120,747 (306)

Glial neurovascular unit protein dysregulation and risk of idiopathic intracranial hypertension: A systematic review and meta-analysis

GMS German Medical Science
Background: Idiopathic intracranial hypertension is a neurological disorder of unclear etiology that primarily affects young adults. Although several therapeutic options are available, many patients continue to experience persistent visual impairment and
Bhoomika Arora, Manabesh Nath, Poorvi Tangri, Pradeep Kumar, Rajesh Kumar Singh, Gyaninder Pal Singh, Deepti Vibha, Achal Kumar Srivastava, Divyani Garg, Ayush Agarwal, Divya M. R., Vishnu V. Y., Awadh Kishor Pandit   +12 more
doaj   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Stromal Regulation of Tumor Perineural Invasion: A Multicellular and Neuro‐Ecological Perspective

Advanced Science, EarlyView.
This review reframes perineural invasion (PNI) as a dynamic, multicellular process within the tumor–nerve–stromal ecosystem. The authors delineate how cancer‐associated fibroblasts, Schwann cells, and immune cells remodel the neural niche to facilitate tumor spread.
Xiaoyang Lin, Yingqiao Liu, Haitao Lin, Kang Feng, Xiqiang Liu   +4 more
wiley   +1 more source

Western Blot analysis of GFAP levels in hippocampus and immunohistochemistry of GFAP positive cells. A1:

, 2012
quantification of GFAP by Western Blot from homogenates of whole hippocampus. Each column represents the levels of GFAP expressed as a ratio of β-actin expression run in the same gel (mean ± SEM; Adult, n = 8; aged, n = 5; aCSF, n = 6; LPS-treated, n = 6)
Polina Petkova-Kirova (135984), Maria Grazia Giovannini (136000), Gary L. Wenk (135997), Sandra Zecchi (135990), Daniele Nosi (135979), Holly M. Brothers (135994), Francesca Cerbai (135968), Daniele Lana (135974)   +7 more
core   +1 more source

Morphological changes of GFAP+-astrocytes in the basal magnocellular nucleus of the rat brain as a result of early pathogenetic correction of colchicine-induced neurodegeneration

Patologìâ
Aim. To describe the morphological features of GFAP-positive cells in the basal magnocellular nucleus (BMN) of the rat brain of experimental rats under conditions of early pathogenetically substantiated correction of colchicine-induced neurodegeneration ...
M. V. Danukalo , Yu. M. Kolesnyk
doaj   +1 more source

Closed‐Loop Decoding and Intervention of Pain: A Novel BMI Strategy Integrating θ‐Band Detection and Mechano‐Electro‐Biological Coupled Hydrogels

Advanced Science, EarlyView.
A closed‐loop brain–machine interface with a PFAPT hydrogel electrode identifies prefrontal θ‐band as a neuropathic pain biomarker. The hydrogel enables stable 28 d ECoG recording and delivers θ‐triggered cortical stimulation, alleviating pain and affective behaviors in rats via bidirectional regulation of inflammation and central sensitization ...
Yun Ji, Tao Li, Guoqiang Lei, Huichun Luo, Xiuqian Guo, Jiao Xiang, Tao Shi, Weitang Liu, Yuxin Zhang, Xiaoyu Liao, Shutao Zhao, Jiayun Wu, Wangao Zhang, Wenhui Liu, Chuanglong He, Shuo Chen, Tao Wu, Ke Ma   +17 more
wiley   +1 more source

Survival-time dependent increase in neuronal IL-6 and astroglial GFAP expression in fatally injured human brain tissue

, 2019
Knowledge on trauma survival time prior to death following a lethal traumatic brain injury (TBI) may be essential for legal purposes. Immunohistochemistry studies might allow to narrow down this survival interval.
Trautz, Florian, Bohnert, Simone, Dreßler, Jan, Franke, Heike, Müller, Wolf, Hammer, Niels, Stassart, Ruth, Ondruschka, Benjamin, Zwirner, Johann, Mueller, Wolf, Tse, Rexson   +10 more
core   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, EarlyView.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source

Immunostaining of cortical astrocytes with GFAP (green) and Hoesct (blue) reveals 95% of cells positively express GFAP.

, 2018
Immunostaining of cortical astrocytes with GFAP (green) and Hoesct (blue) reveals 95% of cells positively express GFAP.
Lisa A. Flanagan (203606), Michael W. Berns (121231), Gladys Mae S. Cruz (5154731), Emmanuel G. Moncada (5154734), Nima Khatibzadeh (381512), Nicole M. Wakida (234417), Clarissa C. Ro (5154737)   +6 more
core   +1 more source

PATIENTS WITH NEUROLOGICAL DISEASES: RATIONALE FOR PHARMACOECONOMIC EVALUATION OF COST OPTIMIZATION FOR MANAGEMENT WITH NEURON-SPECIFIC PROTEINS ASSESSMENT AS MARKERS OF INCREASED BLOOD-BRAIN-BARRIER PERMEABILITY

Фармакоэкономика, 2015
becoming increasingly widespread evaluation of the blood-brain barrier (BBB) resistance to predict severity and outcome of epilepsy, stroke, traumatic brain injury (TBI) and other neurological disorders by assessment of neuron-specific proteins (NSP ...
D. V. Blinov
doaj