Results 151 to 160 of about 127,947 (249)

Huntingtin Aggregate‐Responsive Autophagy Gene Circuit Mitigates Disease Pathology in R6/2 Mice

Advanced Science, EarlyView.
CD98‐mediated receptor‐mediated transcytosis enables LIP‐CD98 nanocarriers to cross the blood–brain barrier and deliver ARAA to neurons. mHTT aggregates activate the 11G–NarX sensor, initiating Auto‐P and Trans‐P signaling through the VP48–NarL relay.
Jie Zhu, Xi‐xiu Xie, Lei Li, Chen Tian, Hao‐tian Wang, Xiao‐jie Wang, Xiao‐lin Yu, Gui‐feng Zhang, Rui‐tian Liu   +8 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Association between serum glial fibrillary acidic protein levels and neurological deficit severity in acute ischemic stroke: A cross-sectional study. [PDF]

Surg Neurol Int
Laksmidewi AAAP, Patricia.
europepmc   +1 more source

Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits

Advanced Science, EarlyView.
This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou, Jianing Jing, Zhuohan Shi, Lei Sun   +3 more
wiley   +1 more source

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

Advanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong, Chen Lin, Wenjie Long, Ian Kim, Mengwen Xiong, Zuer Wu, Siyuan Rao, Qianbin Wang   +7 more
wiley   +1 more source

The interplay of air pollution with plasma neurodegenerative markers and metabolome for dementia, Parkinson's disease and all-cause mortality risks and transitions: The UK Biobank study. [PDF]

Ecotoxicol Environ Saf
Beydoun MA, Huang T, Hu YH, Weiss J, Georgescu MF, Noren Hooten N, Fanelli-Kuczmarski MT, Beydoun HA, Song M, Launer LJ, Evans MK, Zonderman AB.   +11 more
europepmc   +1 more source

Specific, label-free and real-time sensing of glial fibrillary acidic protein (GFAP) in 0.5 μL drop of whole blood with a field-effect biosensor

Pooja Verma, Vijay Garika, Shubham Babbar, Surbhi Rajpoot, Shankar Bhattarai, Sherina Harilal, Avital Eisenberg‐Lerner, Ziv Rotfogel, Evgeny Pikhay, Inna Shehter, Ayala Elkayam, Muhammad Y. Bashouti, Barak Akabayov, Izhar Ron, Yakov Roizin, Raquel C. Gardner, Orit H. Lesman‐Segev, Gil Shalev   +17 more
openalex   +1 more source

Network-based analyses identify GFAP as a cross-domain hub linking synaptic, neuronal, and inflammatory CSF markers in Alzheimer’s disease [PDF]

Chiara Trasciatti, Andrea Pilotto, Chiara Tolassi, Flavio Ragni, Elena Marcello, Monica Moroni, Stefano Bovo, Caterina Martinuzzo, Silvia Pelucchi, Salvatore Caratozzolo, Irene Girotto, Laura D’Andrea, Ramona Stringhi, Andréa Lessa Benedet, Ilaria Pola, Henrik Zetterberg, Nicholas James Ashton, Giuseppe Jurman, Monica Di Luca, Alessandro Padovani   +19 more
openalex   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Developmental brain programmes and biomarker activation in Alzheimer's disease. [PDF]

Brain Commun
Pini L, Margoni M, Filippi M, Imbimbo BP.   +3 more
europepmc   +1 more source