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Role of GFAP in CNS injuries [PDF]
Neuroscience Letters, 2014 The role of GFAP in CNS injury is reviewed as revealed by studies using GFAP null mice. In order to provide background information for these studies, the effects of absence of GFAP in the uninjured astrocyte are also described. Activities attributable to GFAP include suppressing neuronal proliferation and neurite extension in the mature brain, forming ...
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Properties of astrocytes cultured from GFAP over-expressing and GFAP mutant mice [PDF]
Experimental Cell Research, 2009 Alexander disease is a fatal leukoencephalopathy caused by dominantly-acting coding mutations in GFAP. Previous work has also implicated elevations in absolute levels of GFAP as central to the pathogenesis of the disease. However, identification of the critical astrocyte functions that are compromised by mis-expression of GFAP has not yet been possible.
Albee Messing
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Progress in Neurobiology, 2011
Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature astrocytes, but also an important component of the cytoskeleton in astrocytes during development. Major recent developments in astrocyte biology and the discovery of novel intermediate filament functions enticed the interest in the function of GFAP. The discovery
Middeldorp, J., Hol, E.M.
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Glial fibrillary acidic protein (GFAP) is the main intermediate filament protein in mature astrocytes, but also an important component of the cytoskeleton in astrocytes during development. Major recent developments in astrocyte biology and the discovery of novel intermediate filament functions enticed the interest in the function of GFAP. The discovery
Middeldorp, J., Hol, E.M.
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Gene Expression Patterns, 2006
We have generated transgenic zebrafish that express green fluorescent protein (GFP) in glial cells driven by the zebrafish glial fibrillary acidic protein (GFAP) regulatory elements. Transgenic lines Tg(gfap:GFP) were generated from three founders; the results presented here are from the mi2001 line.
Rebecca L, Bernardos, Pamela A, Raymond
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We have generated transgenic zebrafish that express green fluorescent protein (GFP) in glial cells driven by the zebrafish glial fibrillary acidic protein (GFAP) regulatory elements. Transgenic lines Tg(gfap:GFP) were generated from three founders; the results presented here are from the mi2001 line.
Rebecca L, Bernardos, Pamela A, Raymond
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GFAP mutations in Alexander disease
International Journal of Developmental Neuroscience, 2002AbstractAlexander disease is a rare but often fatal disease of the central nervous system. Infantile, juvenile and adult forms have been described that present with different clinical signs, but are unified by the characteristic presence in astrocytes of Rosenthal fibers–protein aggregates that contain glial fibrillary acidic protein (GFAP) and small ...
Rong, Li +3 more
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Expression Specificity of GFAP Transgenes
Neurochemical Research, 2004Glial fibrillary acidic protein (GFAP) is an intermediate filament protein found predominantly in astrocytes. This specificity has recommended the GFAP gene promoter for targeting transgene expression to astrocytes. Although both we [Brenner et al. J. Neurosci. 14:1030-1037, (1994)] and others [Mucke et al. New Biol.
Mu, Su +5 more
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Lesions do not provoke GFAP-expression in the GFAP-immunonegative areas of the teleost brain
Annals of Anatomy - Anatomischer Anzeiger, 2000In the mammalian and avian brains the predominant astroglial elements are astrocytes, and the distribution of GFAP-immunopositivity is rather uneven, some large brain areas being almost devoid of GFAP-immunopositivity. In these areas however, an intense GFAP-immunopositivity appears following injury.
M, Kálmán, B M, Ajtai
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Methods, 1996
The ability to direct expression of genes to astrocytes in mice has been one of the major motivators of transcriptional analyses of the glial fibrillary acidic protein (GFAP) gene. Another has been the possibility of discovering signaling pathways that operate during development, disease, and injury-all states that increase GFAP gene activity-by ...
, Brenner, , Messing
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The ability to direct expression of genes to astrocytes in mice has been one of the major motivators of transcriptional analyses of the glial fibrillary acidic protein (GFAP) gene. Another has been the possibility of discovering signaling pathways that operate during development, disease, and injury-all states that increase GFAP gene activity-by ...
, Brenner, , Messing
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NMOSD or GFAP astrocytopathy? A case report
Multiple Sclerosis and Related Disorders, 2020We describe a 43-year-old female whose manifestations fulfilled the diagnostic criteria of aquaporin-4 IgG negative neuromyelitis optica spectrum disorders (NMOSD). High titer of glial fibrillary acidic protein (GFAP) antibody was detected in cerebrospinal fluid. In this case, some symptoms pertained to NMOSD and some to GFAP antibody-related disorders.
Yue Zhang +2 more
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Neurology, 2010
Endogenous body fluid biomarkers are seldom disease-specific and have to be interpreted in the context of the clinical presentation and in parallel with other diagnostic tests. In this issue of Neurology ®, Takano and colleagues1 present compelling data on the utility of glial fibrillary acidic protein (GFAP), from a panel of cell-specific CSF ...
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Endogenous body fluid biomarkers are seldom disease-specific and have to be interpreted in the context of the clinical presentation and in parallel with other diagnostic tests. In this issue of Neurology ®, Takano and colleagues1 present compelling data on the utility of glial fibrillary acidic protein (GFAP), from a panel of cell-specific CSF ...
openaire +1 more source