Results 291 to 300 of about 194,651 (386)

Evidence of emerging transcriptome mediators of Alzheimer's disease in canine cognitive dysfunction

Brain Pathology, EarlyView.
Canine cognitive dysfunction (CCD) may be a promising model of Alzheimer's disease (AD). To assess AD‐related molecular signatures in CCD, we generated transcriptome data on dog cortex and plasma extracellular vesicles (EVs). CCD‐related transcriptome changes were similar to those in aging/AD humans and were detectable in EVs from the same animals ...
Shelby C. Osburn, Darby S. Easterday, Cali M. McEntee, Amanda S. Latham, Daniel S. Lark, Stephanie McGrath, Julie A. Moreno, Thomas J. LaRocca   +7 more
wiley   +1 more source

The protective effect of neurointerventional recanalization on the neurovascular unit in acute ischemic stroke and its correlation with serum GFAP and NfL levels. [PDF]

Front Neurol
Luo J, Yang Y, Zhou J.
europepmc   +1 more source

Identification of novel FGFR2::TXLNB Fusion in a polymorphous low‐grade neuroepithelial tumor of the young

Brain Pathology, EarlyView.
We report a novel FGFR2::TXLNB fusion in a child with hippocampal PLNTY. This fusion likely drives tumorigenesis via homodimerization and activation of MAPK/PI3K pathways, expanding PLNTY's molecular spectrum and suggesting a potential therapeutic target.
Sha‐Sha Hu, Tian‐Yuan Tan, Wei Yan, Bo Wang   +3 more
wiley   +1 more source

Correlation between blood biomarkers and post-stroke cognitive impairment. [PDF]

Front Aging Neurosci
Liu X, Lv Z, Shi Z, Liu F, Wu H, Liu S, Ji Y.   +6 more
europepmc   +1 more source

Microglial reactivity and nodule formation are associated with Synaptodendritic damage in the brains of people with HIV‐1

Brain Pathology, EarlyView.
Despite effective ART, neurocognitive impairment persists in people with HIV. Brains from PWH present exacerbated microgliosis and formation of microglial nodules that are actively engaged in neuronal phagocytosis, resulting in neuronal injury and dendritic loss.
Roberta S. Dos Reis, Lauren A. Ignatz, Sathish Selvam, Marc C. E. Wagner, Sara Gianella, Antoine Chaillon, Vanessa Gomez‐Moreno, Jeremy Martison, Leah H. Rubin, Sabina Heberlen, Valentina Stosor, Jordan Lake, Velpandi Ayyavoo   +12 more
wiley   +1 more source

Postmortem Associations Between Alzheimer Disease Pathology and Plasma pTau217, GFAP, and NfL in AD and AD-Related Dementias. [PDF]

Neurology
Kivisäkk P, Fatima H, Wu CY, Padmanabhan N, Romero D, Gorham T, Weik M, Dodge HH, Scherzer CR, Das S, Chibnik LB, Blacker DL, Gomez-Isla T, Oakley DH, Frosch MP, Hyman BT, Demos C, Sigal G, Wohlstadter JN, Serrano-Pozo A, Arnold SE.   +20 more
europepmc   +1 more source

Diagnostic performance of plasma GFAP in preclinical stages of Alzheimer’s disease using the Lumipulse platform

Andrea Valera-Barrero, Francisco Martínez-Dubarbie, Armando Guerra, Sara López-García, Carmen Lage, María Rivera-Sánchez, Ana Pozueta-Cantudo, María García-Martínez, Andrea Corrales-Pardo, María Prisila Cevallos Bravo, Marcos López-Hoyos, Juan Irure-Ventura, Heidy Cahuana-Santamaría, María Teresa García-Unzueta, Guglielmo Di Molfetta, Kaj Blennow, Nicholas J. Ashton, Henrik Zetterberg, Pascual Sánchez-Juan, Eloy Rodríguez-Rodríguez, Marta Fernández-Matarrubia   +20 more
openalex   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, EarlyView.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Altered locus coeruleus links to atrophy and hypometabolism in individuals with high Alzheimer's disease biomarkers. [PDF]

Alzheimers Dement
Foyard E, Blanchard T, Landeau B, Chauveau L, Naveau M, Poisnel G, Bui E, Chetelat G, de Flores R, Medit‐Ageing Research Group.   +9 more
europepmc   +1 more source

Immunohistochemical Evaluation of Spinal Cord Injuries Treated with Amniotic Membrane. [PDF]

ACS Omega
de Lima LB, Correia DCC, Sant'anna LB, Arisawa EALS.   +3 more
europepmc   +1 more source