Results 251 to 260 of about 520,090 (317)

Brassinosteroid signaling regulates shoot apical meristem homeostasis via orchestrating cytokinin and WUSCHEL activity. [PDF]

Sci Adv
Wang X, Liu J, Zhao H, Tang Y, Jiang Y, Zhu T, Tian X, Chen D, Lin W, Sun B.   +9 more
europepmc   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

A RUNX2 reporter is expressed prior to osteochondral differentiation and models metaphyseal dysplasia with maxillary hypoplasia and brachydactyly. [PDF]

J Bone Miner Res
Bikas DV, Vardabasso S, Quickstad G, Wyper AN, Shpargel KB.   +4 more
europepmc   +1 more source

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

GPLD1 is a scavenger carrier mediating lysosomal degradation of extracellular aberrant proteins. [PDF]

Life Sci Alliance
Tsuchiya M, Yagishita Y, Itakura E.
europepmc   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, EarlyView.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Rapid assessment of immune effector cell-mediated cytotoxicity using mRNA lipid nanoparticles. [PDF]

Front Immunol
Mollica P, Li J, Kim SH, Goncalves B, Chen Y, Bharti A, O'Neill D, Weber E, Alameh M, Ma L.   +9 more
europepmc   +1 more source

A Stress-Responsive Nuclear Factor, GLDI-8, Mediates Mitochondrial Stress Responses to ETC Dysfunction. [PDF]

Int J Mol Sci
Wu Y, Tang H.
europepmc   +1 more source

Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5. [PDF]

MedComm (2020)
Xie Q, Noettger S, Lawrenz J, Stopper S, Klute S, Münch J, Kmiec D, Wang Q, Sparrer KMJ, Kirchhoff F.   +9 more
europepmc   +1 more source

Screening Atg11, a central organizer of yeast selective autophagy, for residues involved in the Atg11-Atg9 interaction. [PDF]

MicroPubl Biol
Sherpa CD, Woghiren P, Leonello E, Abdel-Khalek M, Schuessler BJ, Vermaas JV, Backues SK.   +6 more
europepmc   +1 more source