Results 141 to 150 of about 17,618 (160)
Some of the next articles are maybe not open access.
Space Science Reviews, 1996
The GHRS has obtained high-resolution spectra of interstellar gas toward 19 nearby stars. These excellent data show that the Sun is located inside the Local Interstellar Cloud (LIC) with other warm clouds nearby. I will summarize the physical properties of these clouds and the three-dimensional structure of this warm interstellar gas.
openaire +2 more sources
The GHRS has obtained high-resolution spectra of interstellar gas toward 19 nearby stars. These excellent data show that the Sun is located inside the Local Interstellar Cloud (LIC) with other warm clouds nearby. I will summarize the physical properties of these clouds and the three-dimensional structure of this warm interstellar gas.
openaire +2 more sources
GH and GHR signaling in human disease
Growth Hormone & IGF Research, 2018Along with its inherent properties in growth promotion, cell division and regeneration, growth hormone (GH) exerts a variety of miscellaneous and widespread actions on the human body after binding to its receptor (GHR). Indeed, GH influences the metabolism of carbohydrates, lipids and proteins; shapes body composition, influences cardiovascular profile,
Jaime, Guevara-Aguirre +5 more
openaire +2 more sources
Regulation of GHR endocytosis: Understanding the GHR-βTrCP interaction
Molecular Biology of the Cell, 2010Upon binding of the Growth Hormone (GH) to the GH receptor (GHR) dimer, a multitude of signalling cascades are triggered that affect cell proliferation, differentiation, and metabolic pathways. The availability of GHR at the cell surface, and consequent responsiveness of cells to GH, can be modulated by tightly controlling the endocytosis of the ...
Almeida, A. +6 more
openaire +1 more source
Physiology and Disorders of the Growth Hormone Receptor (GHR) and GH-GHR Signal Transduction
Endocrine, 2000GH exerts its actions through binding with two receptor molecules at the cell surface and interaction with Janus kinase and signal transducers and activators of transcription, and other likely effectors to stimulate metabolic effects and IGF synthesis. The circulating GH binding protein is the proteolytic product of the cell surface receptor and serves
openaire +2 more sources
Stellar chemical abundances with the GHRS
Physica Scripta, 1996The accurate quantitative analysis of high resolution ultraviolet spectra of ultra-sharp-lined early-type, chemically peculiar stars, obtained with the Goddard High Resolution spectrograph on the Hubble Space Telescope, has been made possible by the synergism between state-of-the-art astro-physics and state-of-the-art atomic spectroscopy. We illustrate
David S Leckrone +4 more
openaire +1 more source
Cardiac Function in GHR–/– Mice
2010The studies discussed in this chapter highlighted the role of GH signaling in heart function, cardiovascular disease, and glucose homeostasis. Interestingly, GHR−/− mice do not present major cardiovascular abnormalities, and their overall cardiovascular risk seems to be diminished, independently of their age and/or gender.
Diana Cruz-Topete, John J. Kopchick
openaire +1 more source
GHR Antagonist: Efficacy and Safety
2011Pegvisomant is a GH receptor antagonist (GHR) licensed for the treatment of acromegaly. The story of the development of pegvisomant began with the recognition of the therapeutic implications of GH gene transgenic mice having a dwarf, rather than giant, phenotype and culminated in studies demonstrating its ability to normalise IGF-I in up to 97% of ...
Claire E. Higham, Peter J. Trainer
openaire +1 more source
2010
The GHR −/− mouse has proven to be a useful and unique model to study the role of GH on growth, development, and function of the CNS. GHR−/− mice show a relative increase in the size of the brain and pituitary with concomitant changes in the morphology of these tissues.
Gosney, Elahu S., Kopchick, John J.
openaire +2 more sources
The GHR −/− mouse has proven to be a useful and unique model to study the role of GH on growth, development, and function of the CNS. GHR−/− mice show a relative increase in the size of the brain and pituitary with concomitant changes in the morphology of these tissues.
Gosney, Elahu S., Kopchick, John J.
openaire +2 more sources
2016
Growth hormone (GH)-induced signaling results in numerous effects in multiple tissues throughout the body. Elucidation of several of these effects has come from studies observing the various phenotypes of the GH receptor (GHR) gene-disrupted (GHR-/-) mouse.
Jonathan A, Young +2 more
openaire +2 more sources
Growth hormone (GH)-induced signaling results in numerous effects in multiple tissues throughout the body. Elucidation of several of these effects has come from studies observing the various phenotypes of the GH receptor (GHR) gene-disrupted (GHR-/-) mouse.
Jonathan A, Young +2 more
openaire +2 more sources
Leukemia Research, 2006
Most human leukemia cells are shown to express growth hormone receptor (GHR) and some of them proliferate in response to GH. We demonstrate that Src contributes to GHR-mediated signal transduction via STAT5 activation in F-36P human leukemia cells stimulated with GH.
Noriko, Manabe +5 more
openaire +2 more sources
Most human leukemia cells are shown to express growth hormone receptor (GHR) and some of them proliferate in response to GH. We demonstrate that Src contributes to GHR-mediated signal transduction via STAT5 activation in F-36P human leukemia cells stimulated with GH.
Noriko, Manabe +5 more
openaire +2 more sources