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Regulation of GHR endocytosis: Understanding the GHR-βTrCP interaction
Molecular Biology of the Cell, 2010Upon binding of the Growth Hormone (GH) to the GH receptor (GHR) dimer, a multitude of signalling cascades are triggered that affect cell proliferation, differentiation, and metabolic pathways. The availability of GHR at the cell surface, and consequent responsiveness of cells to GH, can be modulated by tightly controlling the endocytosis of the ...
Almeida, A. +6 more
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Stellar chemical abundances with the GHRS
Physica Scripta, 1996The accurate quantitative analysis of high resolution ultraviolet spectra of ultra-sharp-lined early-type, chemically peculiar stars, obtained with the Goddard High Resolution spectrograph on the Hubble Space Telescope, has been made possible by the synergism between state-of-the-art astro-physics and state-of-the-art atomic spectroscopy. We illustrate
David S Leckrone +4 more
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Cardiac Function in GHR–/– Mice
2010The studies discussed in this chapter highlighted the role of GH signaling in heart function, cardiovascular disease, and glucose homeostasis. Interestingly, GHR−/− mice do not present major cardiovascular abnormalities, and their overall cardiovascular risk seems to be diminished, independently of their age and/or gender.
Diana Cruz-Topete, John J. Kopchick
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GHR Antagonist: Efficacy and Safety
2011Pegvisomant is a GH receptor antagonist (GHR) licensed for the treatment of acromegaly. The story of the development of pegvisomant began with the recognition of the therapeutic implications of GH gene transgenic mice having a dwarf, rather than giant, phenotype and culminated in studies demonstrating its ability to normalise IGF-I in up to 97% of ...
Claire E. Higham, Peter J. Trainer
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GHR is involved in gastric cell growth and apoptosis via PI3K/AKT signalling
Journal of Cellular and Molecular Medicine, 2021BoSheng He, Hua-Feng Wang
exaly
SINE Insertion in the Intron of Pig GHR May Decrease Its Expression by Acting as a Repressor
Animals, 2021Cai Chen +2 more
exaly
GHR expression and prostate cancer proliferation
Nature Reviews Urology, 2023openaire +2 more sources
PRE-GHR Series Map — Canonical Reference for the PRE-GHR Publication Series (v10)
Canonical reference for the PRE-GHR publication series. v10 (2026-07-31): PRE-GHR XXXIV v2.1 (DOI 10.5281/zenodo.21721908) — external review fixes. (1) M2: §7.3 claim cross-reference corrected (friction failure invisibility = Claim 5, not Claim 2).openaire +1 more source